Results 51 to 60 of about 14,564 (138)

Multi-Overlap Simulations for Transitions between Reference Configurations

, 2003
We introduce a new procedure to construct weight factors, which flatten the probability density of the overlap with respect to some pre-defined reference configuration.
A. Mitsutake, A. Mitsutake, B. Hesselbo, B. von Freyberg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, Bernd A. Berg, D. Hamada, F. Eisenmenger, F. Wang, G.M. Torrie, H. Meirovitch, Hiroshi Noguchi, K. Kuwajima, M.J. Sippl, N. Metropolis, R.A. Sayle, U.H. Hansmann, U.H. Hansmann, U.H. Hansmann, Y. Okamoto, Y. Sugita, Yuko Okamoto, Z. Li   +28 more
core   +1 more source

Global Optimization by Energy Landscape Paving [PDF]

, 2002
We introduce a novel heuristic global optimization method, energy landscape paving (ELP), which combines core ideas from energy surface deformation and tabu search. In appropriate limits, ELP reduces to existing techniques.
C. J. McKnight, D. Cvijovic, D. J. Wales, F. Eisenmenger, F. Eisenmenger, F. Glover, F. Glover, G. Besold, J. Karle, L. T. Wille, L. Wesson, Luc T. Wille, M. J. Sippl, S. Kirkpatrick, T. Ooi, T. Schaumann, U. H. E. Hansmann, U. H. E. Hansmann, Ulrich H. E. Hansmann, W. Wenzel, Y. Duan, Y. Okamoto   +21 more
core   +3 more sources

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Effects of rearing conditions on behaviour and endogenous opioids in rats with alcohol access during adolescence. [PDF]

PLoS ONE, 2013
Causal links between early-life stress, genes and later psychiatric diagnoses are not possible to fully address in human studies. Animal models therefore provide an important complement in which conditions can be well controlled and are here used to ...
Sara Palm, Loudin Daoura, Erika Roman, Ingrid Nylander   +3 more
doaj   +1 more source

Parallel Tempering Algorithm for Conformational Studies of Biological Molecules [PDF]

, 1997
The effectiveness of a new algorithm, parallel tempering, is studied for numerical simulations of biological molecules. These molecules suffer from a rough energy landscape.
Eisenmenger, Geyer, Hansmann, Hansmann, Hansmann, Hansmann, Hansmann, Hansmann, Metropolis, Okamoto, Sipple, Swendsen, Tesi, Tsallis   +13 more
core   +3 more sources

The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract The present review aimed to investigate the effectiveness of aerobic exercise (AE) compared to other interventions in decreasing pain intensity and reducing disability in individuals with neck pain. A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231).
Ana lzabela Sobral de Oliveira‐Souza, Marie Kempe, Sofia Grimmelsmann, Luiz Felipe Tavares, Ester Moreira De Castro‐Carletti, Angela Viegas Andrade, Liz Dennett, Harry Von Piekartz, Jorge Fuentes Contreras, Susan Armijo‐Olivo   +9 more
wiley   +1 more source

Stabilization and Reactions of Sulfur Radical Cations: Relevance to One-Electron Oxidation of Methionine in Peptides and Proteins

CHIMIA, 2008
Methionine is a key amino acid that has numerous roles in essential vital processes. Moreover, methionine oxidation is biologically important during conditions of oxidative stress and represents an important step in the development of some ...
Krzysztof Bobrowski, Chantal Houée-Levin, Bronislaw Marciniak   +2 more
doaj   +1 more source

Wang-Landau molecular dynamics technique to search for low-energy conformational space of proteins

, 2007
Multicanonical molecular dynamics (MD) is a powerful technique for sampling conformations on rugged potential surfaces such as protein. However, it is notoriously difficult to estimate the multicanonical temperature effectively. Wang and Landau developed
Akira R. Kinjo, B. A. Berg, J. W. Neidigh, K. Morikami, Ken Nishikawa, P. Kollman, Takashi Mitsui, Takehiro Nagasima   +7 more
core   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons

Cell Reports, 2019
Summary: Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin ...
Siew H. Yip, Nicola Romanò, Papillon Gustafson, David J. Hodson, Eloise J. Williams, Ilona C. Kokay, Agnes O. Martin, Patrice Mollard, David R. Grattan, Stephen J. Bunn   +9 more
doaj   +1 more source