Results 51 to 60 of about 10,961 (170)

Liver‐ and Immune‐Enriched Molecular Signatures Associated With Mortality in Older Adults

Aging Cell, Volume 25, Issue 7, July 2026.
Untargeted plasma proteomics and metabolomics identified molecular signatures associated with all‐cause mortality in older adults. A liver‐enriched proteomic profile was associated with mortality risk in the ILAS cohort and showed consistent associations in an independent validation cohort, supporting circulating proteomic profiles for mortality risk ...
Yi‐Long Huang, Wei‐Ju Lee, Pei‐Lin Lee, Li‐Ning Peng, Fei‐Yuan Hsiao, Liang‐Kung Chen   +5 more
wiley   +1 more source

One-Year Chromaffin Cell Allograft Survival in Cancer Patients with Chronic Pain: Morphological and Functional Evidence

Cell Transplantation, 1998
The control of chronic pain through transplantation of chromaffin cells has been reported over the past few years. Analgesic effects are principally due to the production of opioid peptides and catecholamines by chromaffin cells.
Jean C. Bés, Jean Tkaczuk, Kimberly A. Czech, Mathieu Tafani, Raymond Bastide, Claude Caratero, George D. Pappas, Yves Lazorthes M.D.   +7 more
doaj   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Adina Borbély, Arnold Steckel, Dávid Papp, Domonkos Pál, Katalin Uray, Viktória Goldschmidt Gőz, Gitta Schlosser   +6 more
wiley   +1 more source

Peptide chirality and opioid receptor modulation: Hepatoprotective effect of d-Met-enkephalin in acetaminophen-induced liver injury

Acta Pharmaceutica
l-Met-enkephalin is a neuropeptide known to exert protective effects in various experimental models of autoimmune and inflammatory diseases. These effects are mediated through opioid receptors and can be abolished by the opioid receptor antagonist ...
Turčić Petra, Martinić Roko, Štambuk Nikola, Weitner Tin, Momčilović Mirna, Boban-Blagaić Alenka, Kos Marina, Stojković Ranko   +7 more
doaj   +1 more source

UHPLC–MS based metabolomics study of the ErZhi formula on skeletal muscle against osteosarcopenia focusing on energy metabolism

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1235-1247, June 2026.
ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang, Ningning Li, Yujie Ding, Shuzhen Hou, Jing Liu, Xiuxue Liu, Erwei Liu, Xiaopeng Chen   +7 more
wiley   +1 more source

Sentience in cephalopod molluscs: an updated assessment

Biological Reviews, Volume 101, Issue 3, Page 1311-1333, June 2026.
ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell, Heather Browning, Andrew Crump, Charlotte C. Burn, Jonathan Birch   +4 more
wiley   +1 more source

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Toward Structure Prediction for Short Peptides Using the Improved SAAP Force Field Parameters

Journal of Chemistry, 2013
Based on the observation that Ramachandran-type potential energy surfaces of single amino acid units in water are in good agreement with statistical structures of the corresponding amino acid residues in proteins, we recently developed a new all-atom ...
Kenichi Dedachi, Taku Shimosato, Toshiya Minezaki, Michio Iwaoka   +3 more
doaj   +1 more source

Investigation of the equilibrium structural and thermodynamic properties of peptide Met-enkephalin in an implicit solvent using parallel-Tempering Simulation [PDF]

EPJ Web of Conferences
The objective of this study is to investigate the equilibrium thermodynamic and structural properties of small proteins in the presence of an implicit solvent using the SMMP package. The work primarily focuses on performing parallel tempering simulations
Rana M., Singh P., Das M., Khinchi S. S., Jain S.   +4 more
doaj   +1 more source