Results 31 to 40 of about 946,904 (210)

Immunocytochemical and ultrastructural differentiation between Met- enkephalin-, Leu-enkephalin-, and Met/Leu-enkephalin-immunoreactive neurons of feline gut

, 1982
Selective immunocytochemical procedures, applied at the light and electron microscopical level, have resulted in the identification of three types of enkephalin-immunoreactive nerves in the feline gastrointestinal tract, including neurons containing ...
K Stengaard-Pendersen, LI Larsson
core   +1 more source

Enteric neuromodulators and mucus discharge in a fish infected with the intestinal helminth Pomphorhynchus laevis

Parasites & Vectors, 2015
Background In vertebrates, the presence of enteric worms can induce structural changes to the alimentary canal impacting on the neuroendocrine system, altering the proper functioning of the gastrointestinal tract and affecting the occurrence and relative
Giampaolo Bosi, Andrew Paul Shinn, Luisa Giari, Bahram Sayyaf Dezfuli   +3 more
doaj   +1 more source

A close neuroanatomical relationship between the enkephalinergic (methionine-enkephalin) and tachykininergic (substance P) systems in the alpaca diencephalon

Folia Histochemica et Cytobiologica, 2020
INTRODUCTION: In the alpaca diencephalon, the distribution of immunoreactive cell bodies and fibers containing methionine-enkephalin (MET) or substance P (SP) has been studied. MATERIAL AND METHODS: The immunohistochemical study was performed by standard
Pablo Sánchez, Manuel Lisardo Sánchez, Arturo Mangas, Luís Ángel Aguilar, Rafael Coveñas   +4 more
doaj   +1 more source

Soybean induced resistance to Spodoptera eridania herbivory

Pest Management Science, EarlyView.
SOD, CAT, APX, PPO, KTI, and MDA levels were higher in the resistant soybean. S. eridania herbivory increased H2O2 and MDA, but decreased SOD and PPO levels. S. eridania herbivory increased KTI activity only in the resistant variety. Isoquercitrin and daidzin were exclusive to resistant and susceptible soybeans.
Bruno Henrique Sardinha de Souza, Arlindo Leal Boiça Júnior, Durvalina Maria Mathias dos Santos, Moacir Rossi Forim, Antonio Pizolato Neto, Andreísa Fabri Lima, Michael Joseph Stout   +6 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Targeted Cell Reprogramming Produces Analgesic Chromaffin-Like Cells from Human Mesenchymal Stem Cells

Cell Transplantation, 2013
Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D., G. Shi, K. Ma, H. N. Yang, W. M. Duan, G. D. Pappas   +5 more
doaj   +1 more source

Inflammatory and healing environment in synovial fluid after anterior cruciate ligament reconstruction: Granulocytes and endogenous opioids as new targets of postoperative pain

Biochemistry and Biophysics Reports, 2021
Background: Biological processes after anterior cruciate ligament reconstruction (ACLR) is crucial for recovery. However, alterations in the of synovial fluid cell population during the acute phase following ACLR and the relationship between these cells ...
Hiroki Katagiri, Kaori Nakamura, Takeshi Muneta, Toshifumi Watanabe, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji   +7 more
doaj   +1 more source

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

Cell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, George D. Pappas   +3 more
doaj   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Adina Borbély, Arnold Steckel, Dávid Papp, Domonkos Pál, Katalin Uray, Viktória Goldschmidt Gőz, Gitta Schlosser   +6 more
wiley   +1 more source