Results 31 to 40 of about 1,366,906 (203)

Immunocytochemical and ultrastructural differentiation between Met- enkephalin-, Leu-enkephalin-, and Met/Leu-enkephalin-immunoreactive neurons of feline gut

, 1982
Selective immunocytochemical procedures, applied at the light and electron microscopical level, have resulted in the identification of three types of enkephalin-immunoreactive nerves in the feline gastrointestinal tract, including neurons containing ...
K Stengaard-Pendersen, LI Larsson
core   +1 more source

Human hepatic met-enkephalin and delta opioid receptor-1 immunoreactivities in viral and autoimmune hepatitis

Annals of Hepatology, 2008
Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized
Vijaya D. Boyella, Anthony D. Nicastri, Nora V. Bergasa   +2 more
doaj   +1 more source

Enteric neuromodulators and mucus discharge in a fish infected with the intestinal helminth Pomphorhynchus laevis

Parasites & Vectors, 2015
Background In vertebrates, the presence of enteric worms can induce structural changes to the alimentary canal impacting on the neuroendocrine system, altering the proper functioning of the gastrointestinal tract and affecting the occurrence and relative
Giampaolo Bosi, Andrew Paul Shinn, Luisa Giari, Bahram Sayyaf Dezfuli   +3 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie International Edition, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

A close neuroanatomical relationship between the enkephalinergic (methionine-enkephalin) and tachykininergic (substance P) systems in the alpaca diencephalon

Folia Histochemica et Cytobiologica, 2020
INTRODUCTION: In the alpaca diencephalon, the distribution of immunoreactive cell bodies and fibers containing methionine-enkephalin (MET) or substance P (SP) has been studied. MATERIAL AND METHODS: The immunohistochemical study was performed by standard
Pablo Sánchez, Manuel Lisardo Sánchez, Arturo Mangas, Luís Ángel Aguilar, Rafael Coveñas   +4 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Cytogenetic Effects of Met-enkephalin (Peptid-M) on Human Lymphocytes [PDF]

, 1998
The structure, complementary structure and cytogenetic/proliferative effects of the Met-enkephalin on human peripheral blood lymphocytes were analyzed. Met-enkephalin, i.e.
Branka Marušić-Della Marina, Pavlić-Renar, Ivana, Šentija, Karmela, Marušić-Della Marina, Branka, Ugrinović, Nikola, Martinić, Roko, Ðurđa Babić-Naglić, Žarković, Neven, Garaj-Vrhovac, Vera, Roko Martinić, Ćurković, Božidar, Brzović, Zdravko, Karmela Šentija, Božidar Ćurković, Nikola Štambuk, Nikola Ugrinović, Ivana Pavlić-Renar, Mirko Hadžija, Štambuk, Nikola, Neven Žarković, Nevenka Kopjar, Vera Garaj-Vrhovac, Pokrić, Biserka, Babić-Naglić, Ðurđa, Hadžija, Mirko, Niko Zurak, Zdenko Biđin, Paško Konjevoda, Vikić-Topić, Dražen, Zurak, Niko, Brinar, Vesna, Vesna Brinar, Dražen Vikić-Topić, Trbojević-Čepe, Milica, Štambuk, Vjera, Biđin, Zdenko, Biserka Pokrić, Vjera Štambuk, Zdravko Brzović, Kopjar, Nevenka, Konjevoda, Paško, Milica Trbojević-Čepe   +41 more
core   +1 more source

Unravelling the Intraspecific Variation in Drought Responses in Seedlings of European Black Pine (Pinus Nigra J.F. Arnold)

Plant, Cell &Environment, EarlyView.
ABSTRACT Understanding intraspecific variation in drought tolerance is essential for predicting the adaptive capacity of forest species under climate change. Yet, the molecular basis of this variation remains poorly understood in ecologically and economically important conifers.
Muhammad Ahmad, Almuth Hammerbacher, Clara Priemer, Albert Ciceu, Marta Karolak, Sonja Mader, Sanna Olsson, Johann Schinnerl, Sebastian Seitner, Selina Schöndorfer, Paula Helfenbein, Jakub Jez, Michaela Breuer, Ana Espinosa‐Ruiz, Teresa Caballero, Andrea Ganthaler, Stefan Mayr, Dominik K. Großkinsky, Stefanie Wienkoop, Silvio Schueler, Carlos Trujillo‐Moya, Marcela van Loo   +21 more
wiley   +1 more source

Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions [PDF]

, 2000
The model of ethanol induced gastric lesions is useful in the evaluation of gastric cytoprotection. We used it to measure cytoprotective effects of two neuropeptides, Met-enkephalin (Peptid-M, LUPEX®) and α-melanocyte stimulating hormone (&alpha ...
Štambuk, Nikola, Ramadan, Pero, Pavan, Josip, Vladimir Mrljak, Zdenko Biđin, Paško Konjevoda, Vikić-Topić, Dražen, Josip Pavan, Dražen Vikić-Topić, Biđin, Zdenko, Pero Ramadan, Boban-Blagaić, Alenka, Smiljka Vikić-Topić, Vikić-Topić, Smiljka, Nikola Štambuk, Konjevoda, Paško, Mrljak, Vladimir, Alenka Boban-Blagaić   +17 more
core   +1 more source