Results 61 to 70 of about 946,904 (210)

Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model-3

, 2011
Inimal or no staining is seen in pancreas of () naïve and () control animals with alcohol and high-fat diet induced pancreatitis. . Met-ENK expression was significantly increased in the pancreas of HSV-ENK-treated animals fed the same diet compared to ...
Yong Ren (86476), Hong Yang (37298), David C Yeomans (37009), Terry A McNearney (86474), Karin N Westlund (86477), Ying Lu (66401), Steven P Wilson (66410), Rong Chu (86475)   +7 more
core   +1 more source

Peptide chirality and opioid receptor modulation: Hepatoprotective effect of d-Met-enkephalin in acetaminophen-induced liver injury

Acta Pharmaceutica
l-Met-enkephalin is a neuropeptide known to exert protective effects in various experimental models of autoimmune and inflammatory diseases. These effects are mediated through opioid receptors and can be abolished by the opioid receptor antagonist ...
Turčić Petra, Martinić Roko, Štambuk Nikola, Weitner Tin, Momčilović Mirna, Boban-Blagaić Alenka, Kos Marina, Stojković Ranko   +7 more
doaj   +1 more source

A Scoping Review of Non‐Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle, Oliver M. Lowden, Rhea E. Sullivan, Taryn E. McFadden, Jennifer E. Nyland   +4 more
wiley   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, Volume 293, Issue 9, Page 2772-2793, May 2026.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source

Freezing of enkephalinergic functions by multiple noxious foci: a source of pain sensitization? [PDF]

PLoS ONE, 2009
BACKGROUND:The functional significance of proenkephalin systems in processing pain remains an open question and indeed is puzzling. For example, a noxious mechanical stimulus does not alter the release of Met-enkephalin-like material (MELM) from segments
François Cesselin, Sylvie Bourgoin, Annie Mauborgne, Michel Hamon, Daniel Le Bars   +4 more
doaj   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, Volume 38, Issue 5, May 2026.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Plasma native and peptidase-derivable Met-enkephalin responses to restraint stress in rats. Adaptation to repeated restraint.

, 1990
Met-enkephalin and related proenkephalin A-derived peptides circulate in plasma at picomolar concentration as free, native pentapeptide and at nanomolar concentration in cryptic forms.
K Pierzchala, Van Loon, G. R., Pierzchala, K., G R Van Loon   +3 more
core   +1 more source

Toward Structure Prediction for Short Peptides Using the Improved SAAP Force Field Parameters

Journal of Chemistry, 2013
Based on the observation that Ramachandran-type potential energy surfaces of single amino acid units in water are in good agreement with statistical structures of the corresponding amino acid residues in proteins, we recently developed a new all-atom ...
Kenichi Dedachi, Taku Shimosato, Toshiya Minezaki, Michio Iwaoka   +3 more
doaj   +1 more source

Investigation of the equilibrium structural and thermodynamic properties of peptide Met-enkephalin in an implicit solvent using parallel-Tempering Simulation [PDF]

EPJ Web of Conferences
The objective of this study is to investigate the equilibrium thermodynamic and structural properties of small proteins in the presence of an implicit solvent using the SMMP package. The work primarily focuses on performing parallel tempering simulations
Rana M., Singh P., Das M., Khinchi S. S., Jain S.   +4 more
doaj   +1 more source