Results 61 to 70 of about 14,564 (138)

Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. [PDF]

PLoS Pathogens, 2009
In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory ...
Heike L Rittner, Dagmar Hackel, Philipp Voigt, Shaaban Mousa, Andrea Stolz, Dominika Labuz, Michael Schäfer, Michael Schaefer, Christoph Stein, Alexander Brack   +9 more
doaj   +1 more source

Parallel Tempering: Theory, Applications, and New Perspectives [PDF]

, 2005
We review the history of the parallel tempering simulation method. From its origins in data analysis, the parallel tempering method has become a standard workhorse of physiochemical simulations.
Alexander-Katz, Auer, Banaszak, Beauvais, Bedrov, Bertrand, Bogarad, Brunger, Bunker, Calco, Calvo, Cecchini, Chen, Chen, Chuang, Ciobanu, Coluzza, David J. Earl, DeWitte, Dova, Dozastakis, Dugourd, Earl, Ekdawi-Sever, Falcioni, Falcioni, Falcioni, Faller, Fasnacht, Favre-Nicolin, Feig, Fenwick, Frenkel, Fukunishi, Garcia, Garcia, Garcia-Cuesta, Gnanakaran, Habeck, Haliloglu, Hansmann, Houdayer, Im, Im, Ishikawa, Jang, Jas, Katzgraber, Katzgraber, Katzgraber, Katzgraber, Kihara, Kofke, Kofke, Kofke, Kokubo, Kokubo, Kone, Kozumi, Lopez, Manousiouthakis, Mastny, Merlitz, Michael W. Deem, Mitsutake, Mitsutake, Murata, Nguyen, Nymeyer, Okamoto, Ortiz, Pagan, Penna, Rabenstein, Rathore, Rathore, Rathore, Rathore, Rathore, Sanbonmatsu, Sanbonmatsu, Schug, Sengupta, Shin, Sugita, Sugita, Sujita, Swendsen, Tsallis, Vlugt, Vreede, Wang, Whitfield, Wu, Yan, Yan, Yan, Yang, Zavalij, Zhou, Zhou, Zhou, Zhou, Zhou   +103 more
core   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Neurotransmitters and putative neuromodulators in the gut of Anguilla anguilla (L.). Localizations in the enteric nervous and endocrine systems

European Journal of Histochemistry, 2009
The gut of silver eels (Anguilla anguilla L.) was investigated in order to describe both the cholinergic and adrenergic intramural innervations, and the localization of possible accessory neuromediators.
A Veggetti, F Mascarello, S Arrighi, G Radaelli, C Domeneghini   +4 more
doaj   +3 more sources

Replica-Exchange Simulated Tempering Method for Simulations of Frustrated Systems

, 2000
We propose a new method for the determination of the weight factor for the simulated tempering method. In this method a short replica-exchange simulation is performed and the simulated tempering weight factor is obtained by the multiple-histogram ...
Ayori Mitsutake, Bartels, Berg, Ferrenberg, Ferrenberg, Hansmann, Hansmann, Hansmann, Hansmann, Hansmann, Hao, Higo, Hukushima, Iba, Irbäck, Irbäck, Kawai, Kumar, Lyubartsev, Marinari, Mitsutake, Mitsutake, Mitsutake, Nakajima, Okamoto, Sippl, Sugita, Sugita, Sugita, Swendsen, Tesi, Yuko Okamoto   +31 more
core   +1 more source

Predicting molecular structures: an application of the cutting angle method [PDF]

, 2003
The ability to predict molecular geometries has important applications in chemistry. Specific examples include the areas of protein space structure elucidation, the investigation of host–guest interactions, the understanding of properties of ...
Batten, Lynn M., Beliakov, Gleb, Lim, Kieran   +2 more
core   +2 more sources

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

One-Year Chromaffin Cell Allograft Survival in Cancer Patients with Chronic Pain: Morphological and Functional Evidence

Cell Transplantation, 1998
The control of chronic pain through transplantation of chromaffin cells has been reported over the past few years. Analgesic effects are principally due to the production of opioid peptides and catecholamines by chromaffin cells.
Jean C. Bés, Jean Tkaczuk, Kimberly A. Czech, Mathieu Tafani, Raymond Bastide, Claude Caratero, George D. Pappas, Yves Lazorthes M.D.   +7 more
doaj   +1 more source

The Evolutionary Biology of Female‐Biased Pain and Its Disorders

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT This article describes and evaluates a general evolutionary theory for explaining variation among individuals in sensitivity to pain, the Vulnerability‐Value‐Opportunity model. The model posits that pain sensitivity is mediated by vulnerability to fitness‐reducing injury (probabilities of damage, including from infection), Fisherian ...
Bernard Crespi
wiley   +1 more source

Generalized-ensemble simulations of spin systems and protein systems

, 2001
In complex systems such as spin systems and protein systems, conventional simulations in the canonical ensemble will get trapped in states of energy local minima.
Ayori Mitsutake, Baxter, Berg, Berg, Berg, Berg, Ferrenberg, Ferrenberg, Ferrenberg, Hansmann, Hansmann, Hansmann, Hansmann, Hansmann, Hukushima, Hukushima, Iba, Irbäck, Kumar, Lyubartsev, Marinari, Marinari, Mitsutake, Mitsutake, Smith, Sugita, Sugita, Sugita, Takehiro Nagasima, Tesi, Wang, Yuji Sugita, Yuko Okamoto   +32 more
core   +1 more source