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Highly reliable LC-MS lipidomics database for efficient human plasma profiling based on NIST SRM 19501 [PDF]

Journal of Lipid Research
Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS)-based methods have become the gold standard methodology for the comprehensive profiling of the human plasma lipidome. However, both the complexity of lipid chemistry and LC-HRMS-
Sara Martínez +4 more
doaj +2 more sources

Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics [PDF]

Scientific Reports
The present study was aimed at revealing the metabolic changes that occurred in the cellular lipid pattern of acute and chronic myeloid leukaemia cells following treatment with cannabidiol (CBD).
David Chamoso-Sanchez +7 more
doaj +2 more sources

Author Correction: Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility [PDF]

Scientific Reports, 2023
Oihane E. Albóniga +12 more
doaj +2 more sources

Lipidomics Unveils Critical Lipid Pathway Shifts in Alport Syndrome [PDF]

Kidney International Reports
Introduction: Alport syndrome (AS) is a hereditary kidney disease from COL4A3–5 pathogenic variants causing glomerular basement membrane abnormalities. Although genetic and structural aspects are known, mechanisms linking collagen IV defects to podocyte ...
Belen Requena +11 more
doaj +2 more sources

Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers

Frontiers in Molecular Biosciences, 2023
It is increasingly evident that a more detailed molecular structure analysis of isomeric lipids is critical to better understand their roles in biological processes.
Sandra M. Camunas-Alberca +6 more
doaj +1 more source

HSP60-Derived Peptide as an LPS/TLR4 Modulator: An in silico Approach

Frontiers in Cardiovascular Medicine, 2022
As a part of innate immunity mechanisms, the Toll-like receptor (TLR) signaling pathway serves as one of the mainstay lines of defense against pathogenic microorganisms and cell dysfunction.
Rafael Gustavo Vila-Casahonda +2 more
doaj +1 more source

Detección de la alteración del metabolismo glucídico y resistencia a la insulina en una muestra piloto infantil: Aproximación metabolómica

Universidad y Salud, 2019
Introducción: La metabolómica permite estudiar la resistencia a insulina (RI), un factor de riesgo de pre-diabetes y diabetes. Quantose IRTM es el único test que mide la RI mediante la abrazadera hiperinsulinémica euglicémica.
Ismael San Mauro-Martin +4 more
doaj +1 more source

Utilización de marcadores bioquímicos como método no invasivo en la determinación de la viabilidad embrionaria en Fertilización In-Vitro

Ciencia & Salud, 2019
Actualmente se ha optado por la implementación de la metabolómica en la fertilización in vitro como un método no invasivo para determinar la viabilidad de los embriones, utilizando la medición de productos secretados o consumidos por el embrión en su ...
Jannin Alfaro +5 more
doaj +1 more source

Biomarcadores y medicina personalizada en las enfermedades raras

Arbor: Ciencia, Pensamiento y Cultura, 2018
Las enfermedades raras, más allá de su baja prevalencia, presentan diferencias con las enfermedades comunes. Los biomarcadores se caracterizan por ser herramientas útiles para determinar y evaluar de un modo objetivo procesos biológicos normales ...
Francesc Palau
doaj +1 more source

Medicina de Precisión para la alergia: el nuevo paradigma del siglo XXI

Revista Methodo, 2023
Individuos con manifestaciones alérgicas similares puede tener subtipos de la enfermedad como consecuencia de la activación de diferentes vías moleculares.
Dos Santos Costa R, Souza da Cruz Filho A A +1 more
doaj +1 more source

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