Metabolic Deregulations in Patients with Polycystic Ovary Syndrome [PDF]
Metabolites, 2023 Polycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications for women worldwide. The aim of this study was to establish the usefulness of new anthropometric indices and atherogenic indices in the evaluation of metabolic ...
Marzena Jabczyk +7 more
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Probiotic: is diet part of the efficacy equation? [PDF]
Gut Microbes, 2023 Discovered at the beginning of the 20th century by Nobel laureate Élie Metchnikoff, probiotics have more recently emerged as a potential noninvasive therapeutic approach for the treatment of various chronic diseases.
Héloïse Rytter +2 more
doaj +2 more sources
Cutaneous Melanoma in the Context of Aging [PDF]
MedicinaAgeing is sustained by a complex network of cellular and molecular mechanisms. The main mechanisms are cellular senescence, telomere attrition, gene expression changes, metabolic dysregulations, oxidative stress and epigenetic modifications such as DNA ...
Monica Neagu +2 more
doaj +2 more sources
The Effects of Chia Defatted Flour as a Nutritional Supplement in C57BL/6 Mice Fed a Low-Quality Diet [PDF]
FoodsToday, consumption of diets rich in saturated fat and fructose, associated with a variety of metabolic deregulations, has increased. The aim of this study was to evaluate the effect of dietary supplementation with a residue of defatted chia seed on a ...
Agustin Lucini Mas +4 more
doaj +2 more sources
In silico and in vitro investigations reveal pan-PPAR agonist activity and anti-NAFLD efficacy of polydatin by modulating hepatic lipid-energy metabolism [PDF]
Scientific ReportsPolydatin (PD), a stilbenoid resveratrol-derivative in Vitaceae, Liliaceae, and Leguminosae, exhibits pharmacological protection in metabolic disorders.
Sumit Kumar Mandal +5 more
doaj +2 more sources
Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies [PDF]
Journal of XenobioticsType 2 diabetes mellitus (T2DM) is an intricate disease correlated with many metabolic deregulations, including disordered glucose metabolism, oxidative stress, inflammation, and cellular apoptosis due to hepatic gluconeogenesis aberrations.
Heba M. Abdou +6 more
doaj +2 more sources
Social overcrowding impacts gut microbiota, promoting stress, inflammation, and dysglycemia
Gut Microbes, 2021 An array of chronic inflammatory diseases, including metabolic diseases such as obesity and diabetes, are thought to be promoted by disturbance of the intestinal microbiota.
Clara Delaroque +3 more
doaj +1 more source
Cells, 2023 Aging and obesity are the two prominent driving forces of metabolic dysfunction, yet the common underlying mechanisms remain elusive. PPARγ, a central metabolic regulator and primary drug target combatting insulin resistance, is hyperacetylated in both ...
Ying He +6 more
doaj +1 more source
Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia. [PDF]
PLoS ONE, 2018 Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been ...
Celine Saint-Laurent +10 more
doaj +1 more source
Cells, 2021 In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+ T cells toward a peculiar differentiation state known as T cell exhaustion, which poses crucial constraints to antiviral immunity.
Valeria Barili +9 more
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