Results 31 to 40 of about 1,774 (249)
Molecules, 2021 Metabolic disorders often lead to cardiac complications. Metabolic deregulations during diabetic conditions are linked to mitochondrial dysfunctions, which are the key contributing factors in cardiac hypertrophy.
Iram Mushtaq +12 more
doaj +1 more source
Deregulation of RNA Metabolism in Microsatellite Expansion Diseases [PDF]
, 2018 RNA metabolism impacts different steps of mRNA life cycle including splicing, polyadenylation, nucleo-cytoplasmic export, translation, and decay. Growing evidence indicates that defects in any of these steps lead to devastating diseases in humans. This chapter reviews the various RNA metabolic mechanisms that are disrupted in Myotonic Dystrophy-a ...
Chaitali, Misra +2 more
openaire +2 more sources
Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer [PDF]
Cancers, 2019 Liver cancer is one of the leading causes of death worldwide due to late diagnosis and scarcity of treatment options. The major risk factor for liver cancer is cirrhosis with the underlying causes of cirrhosis being viral infection (hepatitis B or C), metabolic deregulation (Non-alcoholic fatty liver disease (NAFLD) in the presence of obesity and ...
Eleanna Kaffe +2 more
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MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver
Cells, 2022 MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Yet, whether miR-22 exerts a tumor-suppressive function in the liver has not been investigated in vivo.
Monika Gjorgjieva +9 more
doaj +1 more source
CHTM1, a novel metabolic marker deregulated in human malignancies [PDF]
Oncogene, 2018 A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have found that CHTM1 is associated with cancer and cellular metabolism.
Babbar, Mansi +4 more
openaire +2 more sources
Deregulated coenzyme A, loss of metabolic flexibility and diabetes [PDF]
Biochemical Society Transactions, 2014 CoA (coenzyme A) is an essential cofactor that is emerging as a global regulator of energy metabolism. Tissue CoA levels are tightly regulated and vary in response to different conditions including nutritional state and diabetes. Recent studies reveal the ability of this cofactor to control the output of key metabolic pathways.
Suzanne, Jackowski, Roberta, Leonardi
openaire +2 more sources
Scientific Reports, 2017 Obesity increases susceptibility to multiple organ disorders, however, underlying mechanisms remain unclear. The subclinical inflammation assisted by obesity-induced gut permeability may underlie obesity-associated co-morbidities.
Rizwan Ahmad +4 more
doaj +1 more source
Medicina, 2019 Objectives: The aim of this study was to determine the incidence of metabolic syndrome in patients treated with second-generation antipsychotics (SGAs).
Osama Abo Alrob +7 more
doaj +1 more source
Food preservative sorbic acid deregulates hepatic fatty acid metabolism
Journal of Food and Drug Analysis, 2020 Sorbic acid (SA) is one of the most commonly used food preservatives worldwide. Despite SA having no hepatotoxicity at legal dosages, its effect on hepatic lipid metabolism is still unclear. We investigated the effect of SA on hepatic lipid metabolism and its mechanism of action in C57BL/6 mice.
Chen, Chia-Hui +4 more
openaire +3 more sources
Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis [PDF]
Cancer Cell, 2015 Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in ...
Carroll, Patrick A. +12 more
openaire +2 more sources