Results 51 to 60 of about 574,220 (331)

Genetic and metabolic engineering in diatoms [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2017
Diatoms have attracted considerable attention due to their success in diverse environmental conditions, which probably is a consequence of their complex origins. Studies of their metabolism will provide insight into their adaptation capacity and are a prerequisite for metabolic engineering.
Weichao Huang, Fayza Daboussi
openaire   +4 more sources

Food is our medicine [PDF]

open access: yes, 2012
The paper describes the role of foods and nutrition in the promotion of human health. The relationship between foods, metabolism, homeostasis and metabolic disorder are briefly described.
Sarmidi, Mohamad Roji
core  

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Department of Metabolic Engineering [PDF]

open access: yes, 2002
薬物代謝工学部門は和漢薬の薬効,毒性発現に関与する代謝系の分子生物学的研究を発展させることを設置目的とし,①和漢薬の薬効発現に関与する腸内細菌遺伝子の解析,②薬物代謝機能調節遺伝子の解明とその応用,③腎毒性物質産生機構の分子生物学的解明とその制御に関する研究を課題として取りあげ,和漢薬の薬効発現機構,生体へのレスポンスなどの基礎的研究を通じて,和漢薬の科学的評価や臨床応用をはかることを目指している。主な研究題目を以下に示す。1.
中村 憲夫   +3 more
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

13C-Metabolic Flux Analysis: An Accurate Approach to Demystify Microbial Metabolism for Biochemical Production

open access: yesBioengineering, 2015
Metabolic engineering of various industrial microorganisms to produce chemicals, fuels, and drugs has raised interest since it is environmentally friendly, sustainable, and independent of nonrenewable resources.
Weihua Guo, Jiayuan Sheng, Xueyang Feng
doaj   +1 more source

Computational Approaches in Metabolic Engineering [PDF]

open access: yesJournal of Biomedicine and Biotechnology, 2010
Metabolic engineering involves the adjustment of metabolic and regulatory processes to improve desired cellular behaviors, such as the production of proteins and chemicals. Since cellular metabolic and regulatory networks are often large and complex, the construction and analysis of computational models of these networks can be useful for identifying ...
Jennifer L. Reed   +3 more
openaire   +2 more sources

The sweet branch of metabolic engineering: cherry-picking the low-hanging sugary fruits [PDF]

open access: yes, 2015
In the first science review on the then nascent Metabolic Engineering field in 1991, Dr. James E. Bailey described how improving erythropoietin (EPO) glycosylation can be achieved via metabolic engineering of Chinese hamster ovary (CHO) cells.
Rachel Chen
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Comprehensive evaluation of the capacities of microbial cell factories

open access: yesNature Communications
Systems metabolic engineering is facilitating the development of high-performing microbial cell factories for producing chemicals and materials. However, constructing an efficient microbial cell factory still requires exploring and selecting various host
Gi Bae Kim, Ha Rim Kim, Sang Yup Lee
doaj   +1 more source

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