Results 1 to 10 of about 898,161 (347)

The Regularizing Capacity of Metabolic Networks [PDF]

Physical Review E, 2006
Despite their topological complexity almost all functional properties of metabolic networks can be derived from steady-state dynamics. Indeed, many theoretical investigations (like flux-balance analysis) rely on extracting function from steady states ...
B. Palsson, C. E. Shannon, Carsten Marr, E. Klipp, G. A. Jones, Marc-Thorsten Hütt, Mark Müller-Linow   +6 more
core   +3 more sources

Intravenous branched-chain amino-acid-free solution for the treatment of metabolic decompensation episodes in Spanish pediatric patients with maple syrup urine disease

Frontiers in Pediatrics, 2022
BackgroundMetabolic decompensation episodes (DEs) in Maple Syrup urine disease (MSUD) result in brain accumulation of toxic branched-chain amino acids (BCAAs) and their respective branched-chain α-keto acids that could induce neuroinflammation, disturb ...
Paula Sánchez-Pintos, Paula Sánchez-Pintos, Paula Sánchez-Pintos, Paula Sánchez-Pintos, Silvia Meavilla, Silvia Meavilla, María Goretti López-Ramos, María Goretti López-Ramos, Ángeles García-Cazorla, Ángeles García-Cazorla, Maria L. Couce, Maria L. Couce, Maria L. Couce, Maria L. Couce   +13 more
doaj   +1 more source

Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

Scientific Reports, 2021
Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive ...
E. García-Escobar, S. Valdés, F. Soriguer, J. Vendrell, I. M. Urrutia-Etxebarria, C. Maldonado-Araque, E. Ortega, P. Ocón, E. Montanya, E. Menéndez, A. Lago-Sampedro, T. González-Frutos, R. Gomis, A. Goday, S. García-Serrano, J. L. Galán-García, C. Castell, E. Bordiú, R. Badía, G. Aguilera-Venegas, J. Girbés, S. Gaztambide, E. Delgado, F. J. Chaves, L. Castaño, A. Calle-Pascual, G. Rojo-Martínez, J. Franch-Nadal   +27 more
doaj   +1 more source

Diagnosis and management of children with McArdle Syndrome (GSD V) in New South Wales

JIMD Reports, 2023
Glycogen storage type V (GSD V—McArdle Syndrome) is a rare neuromuscular disorder characterised by severe pain early after the onset of physical activity. A recent series indicated a diagnostic delay of 29 years; hence reports of children affected by the
Louisa Adams, Arthavan Selvanathan, Kiera J. Batten, Nancy vanDoorn, Susan Thompson, Ashleigh Mitchell, Hugo Sampaio, Troy Dalkeith, Jacqui Russell, Carolyn J. Ellaway, Michelle Farrar, Carolyn Broderick, Kaustuv Bhattacharya   +12 more
doaj   +1 more source

The Inflammation in the Cytopathology of Patients With Mucopolysaccharidoses- Immunomodulatory Drugs as an Approach to Therapy

Frontiers in Pharmacology, 2022
Mucopolysaccharidoses (MPS) are a group of lysosomal storage diseases (LSDs), characterized by the accumulation of glycosaminoglycans (GAGs).
Anna-Maria Wiesinger, Anna-Maria Wiesinger, Brian Bigger, Brian Bigger, Roberto Giugliani, Maurizio Scarpa, Maurizio Scarpa, Tobias Moser, Christina Lampe, Christina Lampe, Christoph Kampmann, Florian B. Lagler, Florian B. Lagler   +12 more
doaj   +1 more source

Metabolic Networks of Longevity [PDF]

Cell, 2010
Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health
Houtkooper Riekelt H, Williams Robert W, Auwerx Johan   +2 more
openaire   +3 more sources

Proteome-wide landscape of solubility limits in a bacterial cell

Scientific Reports, 2022
Proteins are prone to aggregate when expressed above their solubility limits. Aggregation may occur rapidly, potentially as early as proteins emerge from the ribosome, or slowly, following synthesis. However, in vivo data on aggregation rates are scarce.
Ádám Györkei, Lejla Daruka, Dávid Balogh, Erika Őszi, Zoltán Magyar, Balázs Szappanos, Gergely Fekete, Mónika Fuxreiter, Péter Horváth, Csaba Pál, Bálint Kintses, Balázs Papp   +11 more
doaj   +1 more source

Liver transplantation in children with inborn errors of metabolism: 30 years experience in NSW, Australia

JIMD Reports, 2021
Background Inborn errors of metabolism (IEM) are a diverse group of genetic disorders that can result in significant morbidity and sometimes death. Metabolic management can be challenging and burdensome for families.
Noha Elserafy, Sue Thompson, Troy Dalkeith, Michael Stormon, Gordon Thomas, Albert Shun, Janine Sawyer, Shanti Balasubramanian, Kaustuv Bhattacharya, Nadia Badawi, Carolyn Ellaway   +10 more
doaj   +1 more source

Identifying functional metabolic shifts in heart failure with the integration of omics data and a heart-specific, genome-scale model

Cell Reports, 2021
Summary: In diseased states, the heart can shift to use different carbon substrates, measured through changes in uptake of metabolites by imaging methods or blood metabolomics.
Bonnie V. Dougherty, Kristopher D. Rawls, Glynis L. Kolling, Kalyan C. Vinnakota, Anders Wallqvist, Jason A. Papin   +5 more
doaj   +1 more source

Patterns of Volatile Diversity Yield Insights Into the Genetics and Biochemistry of the Date Palm Fruit Volatilome

Frontiers in Plant Science, 2022
Volatile organic compounds are key components of the fruit metabolome that contribute to traits such as aroma and taste. Here we report on the diversity of 90 flavor-related fruit traits in date palms (Phoenix dactylifera L.) including 80 volatile ...
Jonathan M. Flowers, Khaled M. Hazzouri, Khaled M. Hazzouri, Alain Lemansour, Tiago Capote, Muriel Gros-Balthazard, Sylvie Ferrand, Marc Lebrun, Marc Lebrun, Khaled M. A. Amiri, Khaled M. A. Amiri, Michael D. Purugganan, Michael D. Purugganan   +12 more
doaj   +1 more source