Results 11 to 20 of about 860,607 (312)

Metabolic pathway engineering

Synthetic and Systems Biotechnology, 2018
Hal S. Alper
doaj   +3 more sources

METABOLIC PATHWAYS [PDF]

Neuro-Oncology, 2013
The kynurenine pathway (KP) is the principal route of L-Tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), and the excitotoxic neurotoxin, quinolinic acid (QUIN).
S. Adams, C. Teo, K. McDonald, A. Zinger, S. Bustamante, C. K. Lim, N. Braidy, B. J. Brew, G. J. Guillemin, S. Agnihotri, K. Burrell, S. Singh, A. Vartanian, A. Wolf, F. Lang, R. Verhaak, C. Hawkins, K. Aldape, G. Zadeh, C. Chesnelong, M. Chaumeil, M. D. Blough, M. Al-Najjar, O. D. Stechishin, S. Ronen, S. Weiss, H. A. Luchman, J. G. Cairncross, E. Fonkem, R. Tobin, J. Griffin, A. Zuzek, M. Rogers, M. Giladi, Y. Wasserman, N. Urman, Y. Porat, R. Schneiderman, M. Munster, U. Weinberg, E. Kirson, Y. Palti, J. Godlewski, A. Bronisz, K. Ansari, D. Ogawa, M. O. Nowicki, E. A. Chiocca, A. Kathagen, A. Schulte, G. Balcke, H. Phillips, H. Gunther, M. Westphal, K. Lamszus, K. Makino, H. Nakamura, T.-i. Hide, S. Yano, J.-i. Kuroda, J.-i. Kuratsu, F. Fack, D. Bonnel, G. Hochart, A. C. Navis, P. Wesseling, W. P. J. Leenders, J. Stauber, S. P. Niclou, F. Sahm, I. Oezen, C. Opitz, B. Radlwimmer, A. von Deimling, H. B. Bode, T. Ahrendt, S. Adams, G. Guillemin, W. Wick, M. Platten, D. Schonberg, D. Lubelski, J. Rich, A. Vartanian, S. K. Singh, K. Burrell, S. Agnihotri, N. Sabha, G. Zadeh   +88 more
  +6 more sources

Astrocyte metabolism and signaling pathways in the CNS

Frontiers in Neuroscience, 2023
Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary cause of neurological diseases, such as depression ...
Yong-mei Zhang, Yong-mei Zhang, Yong-mei Zhang, Ying-bei Qi, Ying-bei Qi, Ying-bei Qi, Ya-nan Gao, Ya-nan Gao, Wen-gang Chen, Wen-gang Chen, Ting Zhou, Ting Zhou, Yi Zang, Yi Zang, Jia Li, Jia Li, Jia Li, Jia Li   +17 more
doaj   +1 more source

The landscape of metabolic pathway dependencies in cancer cell lines.

PLoS Computational Biology, 2021
The metabolic reprogramming of cancer cells creates metabolic vulnerabilities that can be therapeutically targeted. However, our understanding of metabolic dependencies and the pathway crosstalk that creates these vulnerabilities in cancer cells remains ...
James H Joly, Brandon T L Chew, Nicholas A Graham   +2 more
doaj   +1 more source

Metabolomics Analysis of Lettuce (Lactuca sativa L.) Affected by Low Potassium Supply

Agriculture, 2022
Lettuce is a commercially significant leafy vegetable worldwide. Potassium (K) is an essential macronutrient for lettuce growth and development and significantly impacts its metabolites.
Hongyan Gao, Liyan Gong, Jiheng Ni, Qinglin Li   +3 more
doaj   +1 more source

Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

Frontiers in Pharmacology, 2023
Introduction: Usnic acid (UA) and barbatic acid (BA), two typical dibenzofurans and depsides in lichen, have a wide range of pharmacological activities and hepatotoxicity concerns.
Hanxue Wang, Hanxue Wang, Hanxue Wang, Min Xuan, Juanjuan Diao, Nan Xu, Manlin Li, Cheng Huang, Changhong Wang   +8 more
doaj   +1 more source

Branch point control at malonyl-CoA node: A computational framework to uncover the design principles of an ideal genetic-metabolic switch

Metabolic Engineering Communications, 2020
Living organism is an intelligent system coded by hierarchically-organized information to perform precisely-controlled biological functions. Biophysical models are important tools to uncover the design rules underlying complex genetic-metabolic circuit ...
Peng Xu
doaj   +1 more source

Application of HPLC and ESI-MS techniques in the analysis of phenolic acids and flavonoids from green leafy vegetables (GLVs)

Journal of Pharmaceutical Analysis, 2017
Diets containing high proportions of fruits and vegetables reduce the risk of onset of chronic diseases. The role of herbal medicines in improving human health is gaining popularity over the years, which also increases the need for safety and efficiency ...
B. Ramesh Kumar
doaj   +1 more source

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2.
Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette   +31 more
doaj   +1 more source

Genomic reconstruction of short-chain fatty acid production by the human gut microbiota

Frontiers in Molecular Biosciences, 2022
Short-chain fatty acids (SCFAs) including acetate, formate, propionate, and butyrate are the end products of dietary fiber and host glycan fermentation by the human gut microbiota (HGM).
Maria S. Frolova, Inna A. Suvorova, Stanislav N. Iablokov, Sergei N. Petrov, Dmitry A. Rodionov   +4 more
doaj   +1 more source