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Learning motif features and topological structure of molecules for metabolic pathway prediction. [PDF]
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Metabolic pathways of trichothecenes
Drug Metabolism Reviews, 2009Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-
Qinghua, Wu +4 more
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Metabolic Pathways of Ochratoxin A
Current Drug Metabolism, 2011Ochratoxin A (OTA) as a carcinogenic of group 2B to humans is produced by various fungi strains as Aspergillus and Penicillium. It is one of the most common contaminant in foodstuff. OTA is nephrotoxic, hepatotoxic, teratogenic, and immunotoxic and is assumed to cause Balkan Endemic Nephropathy (BEN), a chronic kidney disease in humans when it is ...
Qinghua, Wu +6 more
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On the Origin of Metabolic Pathways
Journal of Molecular Evolution, 1999The heterotrophic theory of the origin of life is the only proposal available with experimental support. This comes from the ease of prebiotic synthesis under strongly reducing conditions. The prebiotic synthesis of organic compounds by reduction of CO(2) to monomers used by the first organisms would also be considered an heterotrophic origin ...
A, Lazcano, S L, Miller
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Chromokinetics of metabolic pathways
European Journal of Biochemistry, 2004Some methods to study and intuitively understand steady‐state flows in complicated metabolic pathways are discussed. For this purpose, a suitable decomposition of complex metabolic schemes into smaller subsystems is used. These independent subsystems are then interpreted as basic colors of a chromatic coloring scheme.
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2016
Understanding metabolic pathways is one of the most important fields in bioscience in the post-genomic era, but curating metabolic pathways requires considerable man-power. As such there is a lack of reliable, experimentally verified metabolic pathways in databases and databases are forced to predict all but the most immediately useful pathways.Text ...
Jan M, Czarnecki, Adrian J, Shepherd
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Understanding metabolic pathways is one of the most important fields in bioscience in the post-genomic era, but curating metabolic pathways requires considerable man-power. As such there is a lack of reliable, experimentally verified metabolic pathways in databases and databases are forced to predict all but the most immediately useful pathways.Text ...
Jan M, Czarnecki, Adrian J, Shepherd
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Main Pathway Discovery in Metabolic Pathways
2010 IEEE 24th International Conference on Advanced Information Networking and Applications Workshops, 2010The requires an integrative biological systems analysis as the quantitative description at the hierarchical level of molecular, cellular and phenotypic functions including their interaction with the environment is very complex. The growing awareness of the complex interplay between the genome and physiological functions of the cell needs a new holistic
Katsumi Inoue +3 more
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Endocannabinoid Metabolic Pathways and Enzymes
Current Drug Target -CNS & Neurological Disorders, 2005Endocannabinoids, defined in 1995 as endogenous agonists of cannabinoid receptors, their anabolic and catabolic pathways, and the enzymes involved in these pathways (the "endocannabinoid enzymes"), are the subject of this review. A general strategy seems to apply to the regulation of the levels of the two major endocannabinoids, anandamide and 2 ...
Ligresti A, Cascio MG, Di Marzo V
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On representation of metabolic pathways
Biosystems, 1998Problems involved in representation of metabolism are dealt with. The specific characteristics of the various ways (verbal, graphical and by electronic means), their advantages and limitations are discussed. New developments in research pose challenges for adequate and clear demonstration of results. Comments on nomenclature and on style are included.
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