Results 111 to 120 of about 3,241,184 (308)
Identification of the Design Principles of Signaling Pathways for Metabolic Engineering [PDF]
The mitogen-activated protein kinase (MAPK) cascades are ubiquitous in eukaryotic signal transduction, and these pathways are conserved in cells from yeast to mammals.
Chachuat, Benoit +3 more
core +1 more source
Important regulatory genes in retinol metabolic pathways.
, 2015 Important regulatory genes in retinol metabolic pathways.
Qingqing Shi (446929) +11 more
core +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Metabolic pathways of methylphenidate in humans.
, 2014 Metabolic pathways of methylphenidate in humans.
Xiaoxia Yang (625366) +11 more
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Colonic Dysregulation of Major Metabolic Pathways in Experimental Ulcerative Colitis
Inflammatory bowel disease (IBD) is multifactorial chronic inflammatory disease in the gastrointestinal tract, affecting patients’ quality of life profoundly. The incidence of IBD has been on the rise globally for the last two decades.
Naser Farhataziz +4 more
core +1 more source
Secreted proteins involved in KEGG metabolic pathways.
, 2016 Secreted proteins involved in KEGG metabolic pathways.
Chulong Zhang (3133386) +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Enzymes related to glycyrrhizic acid metabolic pathways.
, 2015 Enzymes related to glycyrrhizic acid metabolic pathways.
Yaling Liu (204231) +6 more
core +1 more source