Results 61 to 70 of about 3,241,184 (308)

Exploratory metabolomic analysis based on UHPLC-Q-TOF-MS/MS to study hypoxia-reoxygenation energy metabolic alterations in HK-2 cells

Renal Failure, 2023
Purpose Renal ischemia-reperfusion injury(IRI)is a major cause of acute kidney injury(AKI), the injury and repair of renal tubular epithelial cells play an important role in the pathological process of IR-AKI.
Xiaoyu Yang, Ailing Kang, Yuanyue Lu, Yafeng Li, Lili Guo, Rongshan Li, Xiaoshuang Zhou   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome. [PDF]

, 2010
peer-reviewedBackground Currently, a number of bioinformatics methods are available to generate appropriate lists of genes from a microarray experiment.
Morine Melissa J, Aidan P Moloney, Toomey Sinead, Melissa J Morine, McMonagle, Jolene, Roche, Helen M., Gaora Peadar Ó, Moloney, Aidan P, Isobel C Gormley, Helen M Roche, O Gaora, Peadar, Peadar Ó Gaora, Roche Helen M, Moloney Aidan P, Reynolds Clare M, Sinead Toomey, Toomey, Sinead, Jolene McMonagle, Clare M Reynolds, Morine, Melissa J, McMonagle Jolene, Gormley, Isobel C, Gormley Isobel C, Reynolds, Clare M, Roche, Helen M, Gaora, Peadar Ó   +25 more
core   +1 more source

Macrophage metabolomics provides new insights into the metabolic markers and mechanisms of inflammation: review

Food Science and Human Wellness
Macrophages are the core effector cells of the innate immune system. The dysregulation of amino acid, glucose, lipid, and energy metabolism in macrophages has a profound impact on inflammatory pathways.
Senye Wang, Ju Fan, Rui Peng, Wenjing Feng, Suxing Tu, Chao Zhao, Shiming Li, Wenyi Kang, Changyang Ma   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Metabolic pathways of sulfamethoxazole.

, 2014
Metabolic pathways of sulfamethoxazole.
Po-Liang Lu (5309), Chia-Jui Yang (527603), Yi-Chien Lee (625181), Kuan-Yeh Lee (523493), Mao-Song Tsai (523496), Hung-Jen Tang (533197), Shu-Wen Lin (523494), Yen-Hsu Chen (314564), Jen-Jia Yang (625179), Chien-Ching Hung (61132), Chun-Eng Liu (295105), Chung-Hao Huang (625180)   +11 more
core   +1 more source

Path finding methods accounting for stoichiometry in metabolic networks [PDF]

, 2011
Copyright © 2011 Pey et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution ...
Prada, J, Francisco J Planes, Joaquín Prada, Beasley, JE, Pey, J, John E Beasley, Pey, Jon, Prada, Joaquin, Jon Pey, Planes, Francisco J, Planes, FJ, Beasley, John E   +11 more
core   +1 more source

Prognostic value and co-expression patterns of metabolic pathways in cancers

BMC Genomics, 2020
Background Abnormal metabolic pathways have been considered as one of the hallmarks of cancer. While numerous metabolic pathways have been studied in various cancers, the direct link between metabolic pathway gene expression and cancer prognosis has not ...
Dan Zhang, Yan Guo, Ni Xie
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival [PDF]

, 2011
Hypoxia is one of the features of poorly vascularised areas of solid tumours but cancer cells can survive in these areas despite the low oxygen tension.
Tennant, D.A., Zheng, L, Appanna, VD, Watson David G., Kalna, G., Hedley Barbara A., Papkovsky, Dmitri B, Gottlieb Eyal, Papkovsky, D.B., Christian Frezza, Dmitri B. Papkovsky, Frezza, Christian, Hedley, Barbara A, Zheng Liang, Liang Zheng, Hedley, BA, Watson, DG, Kalna, Gabriela, Dmitri B Papkovsky, Tennant, Daniel A., Gabriela Kalna, Frezza, C, Watson, David, Eyal Gottlieb, Tennant Daniel A., Gottlieb, Eyal, Gottlieb, E., David G. Watson, Frezza Christian, Kalna Gabriela, Hedley, B., Daniel A Tennant, Frezza, C., Kalna, G, Barbara A. Hedley, Zheng, L., Barbara A Hedley, Tennant, Daniel; id_orcid, Gottlieb, E, David G Watson, Papkovsky, DB, Papkovsky Dmitri B., Zheng, Liang, Watson, D.G., Daniel A. Tennant   +44 more
core   +2 more sources