Results 71 to 80 of about 3,241,184 (308)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

384 Array Metabolic Pathways.

, 2013
384 Array Metabolic Pathways.
Cinda P. Scott (374521), Jeff VanWye (374522), Douglas L. Crawford (361863), M. Danielle McDonald (374523)   +3 more
core   +1 more source

Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions [PDF]

, 2011
Background: Stable isotope tracers are used to assess metabolic flux profiles in living cells. The existing methods of measurement average out the isotopic isomer distribution in metabolites throughout the cell, whereas the knowledge of compartmental ...
Marin, Silvia, Loranne Agius, Selivanov, Vitaly, Marta Cascante, Roca Elias, Josep, Oresic, Matej, Cascante i Serratosa, Marta, Cascante, Marta, Igor Marin de Mas, Josep Roca, Marín Martínez, Silvia, Selivanov, Vitaly A., de Mas, Igor Marin, Silvia Marin, Agius, Loranne, Vitaly A Selivanov, Matej Orešič, Marín de Mas, Igor Bartolomé, Roca, Josep, Oresic, Matej,, de Mas, Igor Marin,, Roca, Josep,, Agius, Loranne,, Cascante, Marta,, Marin, Silvia,, Selivanov, Vitaly A.,   +25 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome [PDF]

, 2011
Background Our objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS).
Boer, J.M., Dollé Martijn ET, Boer Jolanda MA, Feskens Edith JM, Martijn ET Dollé, Edith JM Feskens, Imholz, S., Feskens, E.J.M., Sandra Imholz, Povel, C.M., Cécile M Povel, Jolanda MA Boer, Imholz Sandra, Povel Cécile M, Dolle, M.E.   +14 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Enriched metabolic pathways

, 2014
KEGG Metabolic pathways in Bactrocera tryoni ...
Mark K. Schutze (3246462), Kumaran, Nagalingam, Kalimuthu Palanivel Mangalam (3246459), Mangalam, Kalimuthu Palanivel, Anthony R. Clarke (185990), Peter J. Prentis (210212), Clarke, Anthony R., Prentis, Peter J., Schutze, Mark K., Nagalingam Kumaran (3246456)   +9 more
core   +1 more source

Kinetic modelling of metabolic pathways [PDF]

, 2011
We show how to build a kinetic model of a metabolic pathway. We provide the example of building a model of glycerol synthesis using Copasi.
Stanford, Natalie J., Smallbone, Kieran
core   +1 more source

Iterconexiunile căilor metabolice ale aminoacizilor din sol la convertirea lor în cadrul ciclului Krebs

Agricultural Science, 2011
On the basis of compared analysis of the data obtained by the author, as well as those cited in the sources of literature, it is presented, for the first time, a summarized characteristic of the peculiarities of Krebs Cycle during the transformation ...
FRUNZE Nina
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source