Results 51 to 60 of about 3,241,184 (308)

Modeling Meets Metabolomics—The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism Caenorhabditis elegans

Frontiers in Molecular Biosciences, 2018
Metabolism is one of the attributes of life and supplies energy and building blocks to organisms. Therefore, understanding metabolism is crucial for the understanding of complex biological phenomena.
Michael Witting, Michael Witting, Janna Hastings, Nicolas Rodriguez, Chintan J. Joshi, Jake P. N. Hattwell, Paul R. Ebert, Michel van Weeghel, Arwen W. Gao, Michael J. O. Wakelam, Riekelt H. Houtkooper, Abraham Mains, Nicolas Le Novère, Sean Sadykoff, Frank Schroeder, Nathan E. Lewis, Nathan E. Lewis, Horst-Joachim Schirra, Christoph Kaleta, Olivia Casanueva   +19 more
doaj   +1 more source

The evolution of fungal metabolic pathways. [PDF]

PLoS Genetics, 2014
Fungi contain a remarkable range of metabolic pathways, sometimes encoded by gene clusters, enabling them to digest most organic matter and synthesize an array of potent small molecules.
Jennifer H Wisecaver, Jason C Slot, Antonis Rokas   +2 more
doaj   +1 more source

Stochastic control of metabolic pathways [PDF]

Physical Biology, 2009
We study the effect of extrinsic noise in metabolic networks. We introduce external random fluctuations at the kinetic level, and show how these lead to a stochastic generalization of standard Metabolic Control Analysis. While Summation and Connectivity Theorems hold true in presence of extrinsic noise, control coefficients incorporate its effect ...
openaire   +5 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effectively Improve the Astaxanthin Production by Combined Additives Regulating Different Metabolic Nodes in Phaffia rhodozyma

Frontiers in Bioengineering and Biotechnology, 2022
Astaxanthin is an important natural resource that is widely found in marine environments. Metabolic regulation is an effective method for improving astaxanthin production in Phaffia rhodozyma.
Zhipeng Li, Zhipeng Li, Zhipeng Li, Haoyi Yang, Haoyi Yang, Haoyi Yang, Chenhua Zheng, Chenhua Zheng, Chenhua Zheng, Xiping Du, Xiping Du, Xiping Du, Hui Ni, Hui Ni, Hui Ni, Ning He, Liang Yang, Liang Yang, Liang Yang, Li You, Li You, Li You, Yanbing Zhu, Yanbing Zhu, Yanbing Zhu, Lijun Li, Lijun Li, Lijun Li   +27 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A text-mining system for extracting metabolic reactions from full-text articles [PDF]

, 2012
Background: Increasingly biological text mining research is focusing on the extraction of complex relationships relevant to the construction and curation of biological networks and pathways. However, one important category of pathway—metabolic pathways—
Czarnecki, Jan M., Nobeli, Irene, Jan Czarnecki, Nobeli, Irilenia, Smith, Adrian M.L., Shepherd Adrian J, Irene Nobeli, Smith Adrian M, Shepherd, Adrian J., Czarnecki Jan, Nobeli Irene, Adrian J Shepherd, Adrian M Smith   +12 more
core   +1 more source

Pathway Tools Management of Pathway/Genome Data for Microbial Communities

Frontiers in Bioinformatics, 2022
The Pathway Tools (PTools) software provides a suite of capabilities for storing and analyzing integrated collections of genomic and metabolic information in the form of organism-specific Pathway/Genome Databases (PGDBs).
Peter D. Karp, Suzanne Paley, Markus Krummenacker, Anamika Kothari, Michael J. Wannemuehler, Gregory J. Phillips   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Metabolic Pathways in Alloreactive T Cells

Frontiers in Immunology, 2020
Allogeneic hematopoietic stem cell transplantation (aHSCT) is a curative therapy for a range of hematologic illnesses including aplastic anemia, sickle cell disease, immunodeficiency, and high-risk leukemia, but the efficacy of aHSCT is often undermined ...
Rebecca A. Brown, Craig A. Byersdorfer
doaj   +1 more source