Results 41 to 50 of about 149 (148)

Livestock metabolomics and the livestock metabolome: A systematic review

PLOS ONE, 2017
Metabolomics uses advanced analytical chemistry techniques to comprehensively measure large numbers of small molecule metabolites in cells, tissues and biofluids. The ability to rapidly detect and quantify hundreds or even thousands of metabolites within a single sample is helping scientists paint a far more complete picture of system-wide metabolism ...
Seyed Ali Goldansaz, An Chi Guo, Tanvir Sajed, Michael A. Steele, Graham S. Plastow, David S. Wishart   +5 more
openaire   +5 more sources

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source

Systems metabolomics: from metabolomic snapshots to design principles

Current Opinion in Biotechnology, 2020
Metabolomics is a rapidly expanding technology that finds increasing application in a variety of fields, form metabolic disorders to cancer, from nutrition and wellness to design and optimization of cell factories. The integration of metabolic snapshots with metabolic fluxes, physiological readouts, metabolic models, and knowledge-informed Artificial ...
Damiani C., Gaglio D., Sacco E., Alberghina L., Vanoni M.   +4 more
openaire   +8 more sources

Analysis of plant metabolomics data using identification‐free approaches

Applications in Plant Sciences, EarlyView.
Abstract Plant metabolomes are structurally diverse. One of the most popular techniques for sampling this diversity is liquid chromatography–mass spectrometry (LC‐MS), which typically detects thousands of peaks from single organ extracts, many representing true metabolites.
Xinyu Yuan, Nathaniel S. S. Smith, Gaurav D. Moghe   +2 more
wiley   +1 more source

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

Arthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

Physiology and Robustness of Yeasts Exposed to Dynamic pH and Glucose Environments

Biotechnology and Bioengineering, EarlyView.
The authors investigated how three Saccharomyces cerevisiae strains respond to dynamic substrate and pH oscillations using dynamic microfluidic single‐cell cultivation (dMSCC) and intracellular biosensors. By combining performance and robustness analysis of selected intracellular parameters, growth and morphological analysis, the authors identified ...
Luca Torello Pianale, Luisa Blöbaum, Alexander Grünberger, Lisbeth Olsson   +3 more
wiley   +1 more source

Microtiter Plate Cultivation Systems Enable Chemically Diverse Metabolic Footprints During Bacterial Natural Product Discovery

Biotechnology and Bioengineering, EarlyView.
The utilization of microtiter plate cultivation systems in the discovery of natural products expands the secondary metabolic footprint. Microtiter plate cultivation systems, in particular the 48 well flower plate, facilitate the parallelization of bacterial cultivation and offer a greater degree of comparability to stirred tank bioreactors in ...
Anton Lindig, Georg Hubmann, Stephan Lütz   +2 more
wiley   +1 more source

Non‐targeted metabolite profiling reveals biochemical diversity of three East Asian mosses

Bulletin of the Korean Chemical Society, EarlyView.
Mosses are known for their bioactive composition and adaptation to environmental stresses. This study explores the metabolic diversity of three East Asian moss species, Niphotrichum japonicum, Calohypnum plumiforme, and Polytrichum formosum, using high‐resolution mass spectrometry. Lipids, particularly unsaturated fatty acids linked to cold adaptation,
Fatima Tuz Zahra, Kyungwon Min, Jungeun Lee, Maeng‐Joon Jung, Hyoungseok Lee, Sunghwan Kim   +5 more
wiley   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source