Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites [PDF]
, 2015 Human malaria parasites proliferate in different erythroid cell types during infection. Whilst Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more pathogenic P. falciparum primarily infects mature erythrocytes.
Barrett, Michael P. +8 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The fecal metabolome as a functional readout of the gut microbiome
Nature Genetics, 2018 The human gut microbiome plays a key role in human health1, but 16S characterization lacks quantitative functional annotation2. The fecal metabolome provides a functional readout of microbial activity and can be used as an intermediate phenotype ...
J. Zierer +12 more
semanticscholar +1 more source
The Role of the Canine Gut Microbiome and Metabolome in Health and Gastrointestinal Disease
Frontiers in Veterinary Science, 2020 The gut microbiome contributes to host metabolism, protects against pathogens, educates the immune system, and, through these basic functions, affects directly or indirectly most physiologic functions of its host.
R. Pilla, J. Suchodolski
semanticscholar +1 more source
Gut, 2021 Objective To profile gut microbiome-associated metabolites in serum and investigate whether these metabolites could distinguish individuals with colorectal cancer (CRC) or adenoma from normal healthy individuals.
Feng Chen +9 more
semanticscholar +1 more source
Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse-Phase Liquid Chromatography (RPLC)-Mass Spectrometry. [PDF]
, 2015 Profiling of body fluids is crucial for monitoring and discovering metabolic markers of health and disease and for providing insights into human physiology.
Contrepois, Kévin +2 more
core +1 more source
Metabolomic analysis of cricket paralysis virus infection in Drosophila S2 cells reveals divergent effects on central carbon metabolism as compared with silkworm Bm5 cells [PDF]
, 2020 High-throughput approaches have opened new opportunities for understanding biological processes such as persistent virus infections, which are widespread.
Meeus, Ivan +5 more
core +1 more source
Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis
Advanced Healthcare Materials, EarlyView.In this research, a novel hydrogel system targeting the colon is developed, incorporating Rhubarb polysaccharides and berberine‐loaded dendrimer. This hydrogel, forms through intermolecular hydrogen bonding and electrostatic interactions, accumulates in colonic tissues, effectively alleviating pathological immune hyperactivation while modulating gut ...
Miao Guo +8 more
wiley +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila +11 more
wiley +1 more source
Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men
Metabolites, 2022 Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to ...
Jani P. Vaara +5 more
doaj +1 more source