Results 71 to 80 of about 161,779 (333)
The Mediterranean diet, plasma metabolome, and cardiovascular disease risk.
European Heart Journal, 2020 AIMS To investigate whether metabolic signature composed of multiple plasma metabolites can be used to characterize adherence and metabolic response to the Mediterranean diet and whether such a metabolic signature is associated with cardiovascular ...
Jun Li +41 more
semanticscholar +1 more source
Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli. [PDF]
, 2016 A significant obstacle in training predictive cell models is the lack of integrated data sources. We develop semi-supervised normalization pipelines and perform experimental characterization (growth, transcriptional, proteome) to create Ecomics, a ...
Kim, Minseung +3 more
core +2 more sources
Advanced Science, EarlyView.In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu +10 more
wiley +1 more source
PlantsCinnamomum osmophloeum Kanehira (CO) is an endemic species of Taiwan. This study elucidated the composition of CO hydrosol, revealing trans-cinnamaldehyde (65.03%), trans-cinnamyl acetate (7.57%), and coumarin (4.31%) as the main volatile compounds ...
Chung-Hsuan Wang +4 more
doaj +1 more source
Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study
Frontiers in Systems Neuroscience, 2013 Recent studies suggest that intestinal microbiota influences gut-brain communication. In this study, we aimed to clarify the influence of intestinal microbiota on cerebral metabolism. We analyzed the cerebral metabolome of germ-free (GF) mice and ex-germ-
Mitsuharu eMatsumoto +6 more
doaj +1 more source
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Science Translational Medicine, 2021 Peripheral blood dynamics in the 100 days before delivery reveal a transition from pregnancy maintenance to prelabor biology. Toward better prediction of labor Current methods to predict spontaneous labor are fairly inaccurate.
I. Stelzer +37 more
semanticscholar +1 more source
Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure [PDF]
, 2019 Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects.
Ashley, Patricia L. +10 more
core +1 more source
Advanced Science, EarlyView.The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou +11 more
wiley +1 more source
Metabolites, 2022 Prenatal exposure to phthalates, a family of endocrine-disrupting plasticizers, is associated with disruption of maternal metabolism and impaired neurodevelopment.
Mariana Parenti +8 more
doaj +1 more source
Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids [PDF]
, 2019 A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate with highly adapted and ...
Mazmanian, Sarkis +2 more
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