Results 81 to 90 of about 151,525 (322)
Advanced Science, EarlyView.This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang +10 more
wiley +1 more source
MetabolitesChanges in thyroid hormone (TH) levels in rat brain at early developmental stages are correlated with adverse effects on offspring development. To characterize the ability of substances to interfere with the TH concentrations in, e.g., rat brain, it is ...
Christiane Hindrichs +6 more
doaj +1 more source
Metabolomics for Biomarker Discovery in Gastroenterological Cancer
Metabolites, 2014 The study of the omics cascade, which involves comprehensive investigations based on genomics, transcriptomics, proteomics, metabolomics, etc., has developed rapidly and now plays an important role in life science research.
Shin Nishiumi +5 more
doaj +1 more source
MetaboTools: A comprehensive toolbox for analysis of genome-scale metabolic models [PDF]
, 2016 Metabolomic data sets provide a direct read-out of cellular phenotypes and are increasingly generated to study biological questions. Our previous work revealed the potential of analyzing extracellular metabolomic data in the context of the metabolic ...
Aurich, Maike K. +2 more
core +3 more sources
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Time resolved cell painting enables rapid assessment of cell phenotypes
SLAS DiscoveryCell Painting is an advanced imaging technique for drug discovery used to study cellular phenotypes by simultaneously labeling various organelles/structures and analyzing the resulting multidimensional phenotypic features through a sophisticated data ...
Franziska A. Hecker +4 more
doaj +1 more source
Metabolomic analysis by UAE-GC MS and antioxidant activity of Salvia hispanica (L.) seeds grown under different irrigation regimes [PDF]
, 2018 Chia (Salvia hispanica L.) is an emerging crop with a high content of α-linolenic acid and metabolites of industrial and pharmaceutical interest but information on metabolome variations in response to agricultural management is scarce.
Amato, Mariana +4 more
core +2 more sources
Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay
Advanced Science, EarlyView.This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao +6 more
wiley +1 more source
Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. [PDF]
, 2020 IntroductionDisruption of metabolic function is a recognized feature of late onset Alzheimer's disease (LOAD). We sought to determine whether similar metabolic pathways are implicated in adults with Down syndrome (DS) who have increased risk for ...
Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators +12 more
core
Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]
, 2019 The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V +3 more
core +1 more source