Results 1 to 10 of about 271,198 (347)

The metabolic consequences of HIV/TB co-infection

open access: yesBMC Infectious Diseases, 2023
Background The synergy between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis during co-infection of a host is well known. While this synergy is known to be driven by immunological deterioration, the metabolic mechanisms that ...
Chandré Herbert   +3 more
doaj   +1 more source

Optimising a urinary extraction method for non-targeted GC–MS metabolomics

open access: yesScientific Reports, 2023
Urine is ideal for non-targeted metabolomics, providing valuable insights into normal and pathological cellular processes. Optimal extraction is critical since non-targeted metabolomics aims to analyse various compound classes.
Cara Olivier, Bianca Allen, Laneke Luies
doaj   +1 more source

HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review

open access: yesBMC Infectious Diseases, 2023
HIV-1 remains a global health concern and to date, nearly 38 million people are living with HIV. The complexity of HIV-1 pathogenesis and its subsequent prevalence is influenced by several factors including the HIV-1 subtype.
Piwai Terry Gotora   +2 more
doaj   +1 more source

Transcriptionally imprinted glycomic signatures of acute myeloid leukemia

open access: yesCell & Bioscience, 2023
Background Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagnant survival curves for decades.
Constantin Blöchl   +4 more
doaj   +1 more source

In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis

open access: yesMicrobiology Spectrum, 2022
The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics and the high costs for clinical trials, hampers the development of novel antimicrobial agents with improved efficacy and safety.
Kirsten E. Knoll   +2 more
doaj   +1 more source

Analysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit

open access: yesScientific Reports, 2022
The AbsoluteIDQ p400 HR kit is a commercial product for targeted metabolomics. While the kit has been validated for human plasma and serum, adherent cell lysates have not yet been evaluated.
Raphaela Fritsche-Guenther   +3 more
doaj   +1 more source

Metabolite profiling of susceptible and resistant wheat (Triticum aestivum) cultivars responding to Puccinia striiformis f. sp. tritici infection

open access: yesBMC Plant Biology, 2023
Background Puccinia striiformis f. sp. tritici (Pst) is an economically devasting disease that is prominent in cereal crops such as wheat (Triticum aestivum). The fungal pathogen can cause approximately 30–70% losses in crop productivity and yields.
Manamele Dannies Mashabela   +5 more
doaj   +1 more source

Differences in the Stool Metabolome between Vegans and Omnivores: Analyzing the NIST Stool Reference Material

open access: yesMetabolites, 2023
To gain confidence in results of omic-data acquisitions, methods must be benchmarked using validated quality control materials. We report data combining both untargeted and targeted metabolomics assays for the analysis of four new human fecal reference ...
Raquel Cumeras   +5 more
doaj   +1 more source

Serum-Urine Matched Metabolomics for Predicting Progression of Henoch-Schonlein Purpura Nephritis

open access: yesFrontiers in Medicine, 2021
Henoch-Schonlein purpura nephritis (HSPN) is a common glomerulonephritis secondary to Henoch-Schonlein purpura (HSP) that affects systemic metabolism. Currently, there is a rarity of biomarkers to predict the progression of HSPN.
Qian Zhang   +7 more
doaj   +1 more source

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