Results 21 to 30 of about 210,196 (287)
Current Drug Metabolism, 2008 Metabolomics is based on the simultaneous analysis of multiple low-molecular-weight metabolites from a given sample. The goals of metabolomics are to catalog and quantify the myriad small molecules found in biological fluids under different conditions. The metabolomics represents the collection of all metabolites in a biological organism, and metabolic
V S, Gomase +3 more
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Xenobiotic Metabolomics: Major Impact on the Metabolome [PDF]
Annual Review of Pharmacology and Toxicology, 2012 Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity.
Caroline H, Johnson +3 more
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Cancer Metabolomics and the Human Metabolome Database [PDF]
Metabolites, 2016 The application of metabolomics towards cancer research has led to a renewed appreciation of metabolism in cancer development and progression. It has also led to the discovery of metabolite cancer biomarkers and the identification of a number of novel cancer causing metabolites.
David S. Wishart +3 more
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Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
Nature Communications, 2019 In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in
Guinevere S. M. Lageveen-Kammeijer +7 more
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The METLIN small molecule dataset for machine learning-based retention time prediction
Nature Communications, 2019 The use of machine learning for identifying small molecules through their retention time’s predictions has been challenging so far. Here the authors combine a large database of liquid chromatography retention time with a deep learning approach to enable ...
Xavier Domingo-Almenara +8 more
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Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
OncoImmunology, 2023 In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of ...
Marine Fidelle +3 more
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Current Genomics, 2011 Microbial metabolomics constitutes an integrated component of systems biology. By studying the complete set of metabolites within a microorganism and monitoring the global outcome of interactions between its development processes and the environment, metabolomics can potentially provide a more accurate snap shot of the actual physiological state of the
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SECIMTools: a suite of metabolomics data analysis tools
BMC Bioinformatics, 2018 Background Metabolomics has the promise to transform the area of personalized medicine with the rapid development of high throughput technology for untargeted analysis of metabolites.
Alexander S. Kirpich +8 more
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BMC Plant Biology, 2021 Background Surveillance of potential pathogens is a key feature of plant innate immunity. For non-self-recognition plants rely on the perception of pathogen-derived molecules.
Dylan R. Zeiss +3 more
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International Journal of Reproductive BioMedicine, 2021 Background: Prostate cancer (PCa) is a common health problem worldwide. The rate of this disease is likely to grow by 2021. PCa is a heterogeneous disorder, and various biochemical factors contribute to the development of this disease.
Ziba Akbari +4 more
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