Results 11 to 20 of about 1,802 (157)

Surface antigens of metacyclic trypomastigotes of Trypanosoma cruzi [PDF]

Infection and Immunity, 1983
The surface antigen makeup of metacyclic trypomastigote forms of strain G of Trypanosoma cruzi, which produce a subpatent infection in mice, differed from those of the virulent strains Y and CL. A 100,000-molecular-weight protein, barely detectable on the Y or CL cell surface, appeared as the main surface antigen of the G metacyclic trypomastigotes. In
Nobuko Yoshida
exaly   +3 more sources

Trypanosoma cruzi: Maintenance in Culture Modify Gene and Antigenic Expression of Metacyclic Trypomastigotes [PDF]

Memorias do Instituto Oswaldo Cruz, 1998
In this study we examined whether the maintenance of Trypanosoma cruzi by long-time in axenic culture produces changes in gene expression and antigenic profiles.
Víctor T Contreras, Ana Rita De Lima, Gelu Zorrilla   +2 more
doaj   +4 more sources

Effects of TcFLA-1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures. [PDF]

Cell Biol Int
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Souza-Melo N, de Souza GH, de Souza W.
europepmc   +2 more sources

Polymorphism of the 35- and 50-kilodalton surface glycoconjugates of Trypanosoma cruzi metacyclic trypomastigotes [PDF]

Infection and Immunity, 1992
In this study, we examined the immunochemical properties of the 35- and 50-kDa (35/50-kDa) surface glycoconjugates expressed on the surface of metacyclic trypomastigotes of Trypanosoma cruzi using three different monoclonal antibodies directed to this component.
Renato A Mortara, Nobuko Yoshida
exaly   +3 more sources

Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle of Trypanosoma cruzi [PDF]

Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits remarkable developmental plasticity that enables its survival across distinct environments within the insect vector and mammalian host.
Abel Sana, Izadora Volpato Rossi, Marcel Ivan Ramirez   +2 more
doaj   +2 more sources

Signal transduction induced in Trypanosoma cruzi metacyclic trypomastigotes during the invasion of mammalian cells [PDF]

Brazilian Journal of Medical and Biological Research, 2000
Penetration of Trypanosoma cruzi into mammalian cells depends on the activation of the parasite's protein tyrosine kinase and on the increase in cytosolic Ca2+ concentration. We used metacyclic trypomastigotes, the T.
N. Yoshida, S. Favoreto Jr., A.T. Ferreira, P.M. Manque   +3 more
doaj   +6 more sources

Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-β1. [PDF]

J Extracell Vesicles
Abstract During cell invasion, large Extracellular Vesicle (lEV) release from host cells was dose‐dependently triggered by Trypanosoma cruzi metacyclic trypomastigotes (Mtr). This lEV release was inhibited when IP3‐mediated Ca2+ exit from the ER and further Ca2+ entry from plasma membrane channels was blocked, but whilst any store‐independent Ca2 ...
Ansa-Addo EA, Pathak P, McCrossan MV, Volpato Rossi I, Abdullahi M, Stratton D, Lange S, Ramirez MI, Inal JM.   +8 more
europepmc   +2 more sources

The Kinetoplastid-Specific Protein TcCAL1 Plays Different Roles During In Vitro Differentiation and Host-Cell Invasion in Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2022
In the pathogen Typanosoma cruzi, the calcium ion (Ca2+) regulates key processes for parasite survival. However, the mechanisms decoding Ca2+ signals are not fully identified or understood.
Jessica Rodríguez-Durán, Juan Pablo Gallardo, Catalina Dirney Alba Soto, Karina Andrea Gómez, Mariana Potenza   +4 more
doaj   +1 more source

Transcriptomic changes across the life cycle of Trypanosoma cruzi II [PDF]

PeerJ, 2020
Trypanosoma cruzi is a flagellated protozoan that causes Chagas disease; it presents a complex life cycle comprising four morphological stages: epimastigote (EP), metacyclic trypomastigote (MT), cell-derived trypomastigote (CDT) and amastigote (AM ...
Lissa Cruz-Saavedra, Gustavo A. Vallejo, Felipe Guhl, Juan David Ramírez   +3 more
doaj   +2 more sources

Translational repression by an RNA-binding protein promotes differentiation to infective forms in Trypanosoma cruzi. [PDF]

PLoS Pathogens, 2018
Trypanosomes, protozoan parasites of medical importance, essentially rely on post-transcriptional mechanisms to regulate gene expression in insect vectors and vertebrate hosts.
Maria Albertina Romaniuk, Alberto Carlos Frasch, Alejandro Cassola   +2 more
doaj   +1 more source