Results 21 to 30 of about 1,802 (157)

Transcriptional remodeling during metacyclogenesis in Trypanosoma cruzi I

Virulence, 2020
Metacyclogenesis is one of the most important processes in the life cycle of Trypanosoma cruzi. In this stage, noninfective epimastigotes become infective metacyclic trypomastigotes.
Lissa Cruz-Saavedra, Gustavo A. Vallejo, Felipe Guhl, Louisa A. Messenger, Juan David Ramírez   +4 more
doaj   +1 more source

Plasminogen interaction with Trypanosoma cruzi [PDF]

Memorias do Instituto Oswaldo Cruz, 2004
The ability of Trypanosoma cruzi to interact with plasminogen, the zimogenic form of the blood serin protease plasmin, was examined. Immunohistochemistry studies revealed that both forms, epimastigotes and metacyclic trypomastigotes, were able to fix ...
Laura Almeida, Gilmer Vanegas, Marina Calcagno, Juan Luis Concepción, Luisana Avilan   +4 more
doaj   +1 more source

The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector.

PLoS Pathogens, 2023
Trypanosoma brucei spp. develop into mammalian-infectious metacyclic trypomastigotes inside tsetse salivary glands. Besides acquiring a variant surface glycoprotein (VSG) coat, little is known about the metacyclic expression of invariant surface antigens.
Aitor Casas-Sanchez, Raghavendran Ramaswamy, Samïrah Perally, Lee R Haines, Clair Rose, Marcela Aguilera-Flores, Susana Portillo, Margot Verbeelen, Shahid Hussain, Laura Smithson, Cristina Yunta, Michael J Lehane, Sue Vaughan, Jan van den Abbeele, Igor C Almeida, Martin J Boulanger, Álvaro Acosta-Serrano   +16 more
doaj   +1 more source

Role of GP82 in the selective binding to gastric mucin during oral infection with Trypanosoma cruzi. [PDF]

PLoS Neglected Tropical Diseases, 2010
Oral infection by Trypanosoma cruzi has been the primary cause of recent outbreaks of acute Chagas' diseases. This route of infection may involve selective binding of the metacyclic trypomastigote surface molecule gp82 to gastric mucin as a first step ...
Daniela I Staquicini, Rafael M Martins, Silene Macedo, Gisela R S Sasso, Vanessa D Atayde, Maria A Juliano, Nobuko Yoshida   +6 more
doaj   +1 more source

All Roads Lead to Cytosol: Trypanosoma cruzi Multi-Strategic Approach to Invasion

Frontiers in Cellular and Infection Microbiology, 2021
T. cruzi has a complex life cycle involving four developmental stages namely, epimastigotes, metacyclic trypomastigotes, amastigotes and bloodstream trypomastigotes.
Gabriel Ferri, Martin M. Edreira, Martin M. Edreira, Martin M. Edreira   +3 more
doaj   +1 more source

Characterization of messenger RNA from epimastigotes and metacyclic trypomastigotes of Trypanosoma cruzi [PDF]

FEBS Letters, 1985
The cell‐free translation products of polyribosomal and post‐polyribosomal mRNAs from the non‐infective epimastigotes and the infective metacyclic trypomastigotes of the parasitic protozoan Trypanosoma cruzi were compared by two‐dimensional polyacrylamide gel electrophoresis.
Goldenberg, S., Salles, J.M., Contreras, V.T., Franco, M.P.Lima, Katzin, A.M., Colli, W., Morel, C.M.   +6 more
openaire   +2 more sources

Differential gene expression during Trypanosoma cruzi metacyclogenesis

Memorias do Instituto Oswaldo Cruz, 1999
The transformation of epimastigotes into metacyclic trypomastigotes involves changes in the pattern of expressed genes, resulting in important morphological and functional differences between these developmental forms of Trypanosoma cruzi.
Marco Aurelio Krieger, Andrea Rodrigues Ávila, Sueli Fumie Yamada Ogatta, Claire Plazanet-Menut, Samuel Goldenberg   +4 more
doaj   +1 more source

Molecular characterization of Trypanosoma cruzi SAP proteins with host-cell lysosome exocytosis-inducing activity required for parasite invasion. [PDF]

PLoS ONE, 2013
To invade target cells, Trypanosoma cruzi metacyclic forms engage distinct sets of surface and secreted molecules that interact with host components. Serine-, alanine-, and proline-rich proteins (SAP) comprise a multigene family constituted of molecules ...
Tamiris Zanforlin, Ethel Bayer-Santos, Cristian Cortez, Igor C Almeida, Nobuko Yoshida, José Franco da Silveira   +5 more
doaj   +1 more source

The First Contact of Human Dendritic Cells With Trypanosoma cruzi Reveals Response to Virus as an Unexplored Central Pathway

Frontiers in Immunology, 2021
Chagas disease is a debilitating and neglected disease caused by the protozoan Trypanosoma cruzi. Soon after infection, interactions among T. cruzi and host innate immunity cells can drive/contribute to disease outcome.
Natalia Gil-Jaramillo, Amanda Pereira Rocha, Tainá Raiol, Flávia Nader Motta, Flávia Nader Motta, Cecília Favali, Marcelo M. Brigido, Izabela M. D. Bastos, Jaime M. Santana   +8 more
doaj   +1 more source

Parameters affecting cellular invasion and escape from the parasitophorous vacuole by different infective forms of Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2003
In this study we have examined certain aspects of the process of cell invasion and parasitophorous vacuole escape by metacyclic trypomastigotes and extracellular amastigote forms of Trypanosoma cruzi (G strain). Using Vero (and HeLa) cells as targets, we
RB Stecconi-Silva, WK Andreoli, RA Mortara   +2 more
doaj   +1 more source