Results 111 to 120 of about 33,548 (283)

OGFRL1 deficiency causes CRMO via pathological osteoclastogenesis, with therapeutic response to TNF inhibitor

Arthritis &Rheumatology, Accepted Article.
Objectives To verify the pathogenesis of the OGFRL1 loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a CRMO patient and investigate the underlying mechanism. Methods Whole exome sequencing and Sanger sequencing were performed to identify and confirm the variant.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Unravelling the enigma of the human microbiome: Evolution and selection of sequencing technologies

Microbial Biotechnology
The human microbiome plays a crucial role in maintaining health, with advances in high‐throughput sequencing technology and reduced sequencing costs triggering a surge in microbiome research.
Xin Yi, Hong Lu, Xiang Liu, Junyi He, Bing Li, Zhelong Wang, Yujing Zhao, Xinri Zhang, Xiao Yu   +8 more
doaj   +1 more source

Pathogenic Detection by Metagenomic next-generation Sequencing in Spinal Infections

Spine
Study Design. Retrospective, observational study. Objective. To evaluate the ability and value of metagenomic next-generation sequencing (mNGS) in detecting pathogens from spinal infections. Background.
Chuqiang Yin, Yanan Cong, Huafeng Wang, Dechun Wang, Xizhong Yang, Xuesong Wang, Ting Wang   +6 more
openaire   +2 more sources

A systematic review evaluating the performance of eDNA methods relative to conventional methods for biodiversity monitoring

Ecography, EarlyView.
The rapid adoption of environmental DNA (eDNA) methods has drastically changed biodiversity monitoring efforts. It is often claimed that eDNA methods are more sensitive and efficient than conventional biodiversity monitoring methods, but it is often unclear what metrics support this claim.
Nicholas J. Iacaruso, Olivia P. Reves, Sara J. Merkelz, Cassidy L. Waldrep, Mark A. Davis   +4 more
wiley   +1 more source

Application of targeted metagenomic next-generation sequencing in pneumonia patients

Microbiology Spectrum
After the coronavirus disease 2019 (COVID-19) pandemic, the incidence rate of mixed infections, especially in critically ill patients with severe pneumonia, increases due to the immunity gap and has also been proven to be associated with mortality ...
Guanjun Ren, Liyun Ma, Chunliang Yan, Qishan Xue, Huijuan Zhang, Wei Wang, Xiyan Ren, Yun Lei, Shaofei Li, Yafeng Liu, Qingyue Zheng, Shigang Wei, Yue Zhang, Xiao Wang   +13 more
doaj   +1 more source

Assembling large, complex environmental metagenomes

, 2012
The large volumes of sequencing data required to sample complex environments deeply pose new challenges to sequence analysis approaches. De novo metagenomic assembly effectively reduces the total amount of data to be analyzed but requires significant ...
Brown, C. Titus, Howe, Adina Chuang, Jansson, Janet, Malfatti, Stephanie A., Tiedje, James M., Tringe, Susannah G.   +5 more
core  

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Faecal Microbiota Transplantation in Anorexia Nervosa: A Systematic Review of Methodologies, Outcomes, and Challenges With Recommendations for Future Studies

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder displaying an altered gut microbiome. Faecal microbiome transplantation (FMT) has emerged as a powerful research tool and potential treatment option in AN due to the microbiome‐gut‐brain axis. Current studies are limited and reveal variable FMT protocols.
Anna C. Thelen, Nele M. Korten, Larissa Blischke, Clara Voelz, Cordian Beyer, Jochen Seitz, Stefanie Trinh   +6 more
wiley   +1 more source

Diagnosis and Surveillance of Neonatal Infections by Metagenomic Next-Generation Sequencing [PDF]

, 2022
Rong Zhang, Yan Zhuang, Zhenghui Xiao, Caiyun Li, Fan Zhang, Weiqing Huang, Min Zhang, Xiaoming Peng, Chao Liu   +8 more
openalex   +1 more source

Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome

Equine Veterinary Journal, EarlyView.
Abstract Background Based on human studies, surgical antimicrobial (AMD) prophylaxis (SAP) beyond 24 h is unnecessary and potentially detrimental. Objective To compare clinical and microbiological outcomes in patients receiving 24‐ or 72‐h of SAP for colic surgery. Study Design Prospective randomised clinical trial.
Louise L. Southwood, Alicia Long, Jairo Perez, Scott Daniel, Kyle Bittinger, Maia Aitken, Laurel Redding   +6 more
wiley   +1 more source