Results 21 to 30 of about 12,806 (157)

DOTA-grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance-reversal Agents (MRRAs) Combating Against New Delhi Metallo-β-lactamase (NDM)-producing Bacteria. [PDF]

Adv Sci (Weinh)
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Wang R, Zhang J, Li Y, Qiao L, Dong Z, Cui D, Bai P, Li L, Cao B, Zhang R.   +9 more
europepmc   +2 more sources

Biochemical characterization of the carbapenem-hydrolyzing β-lactamase AsbM1 fromAeromonas sobriaAER 14M: a member of a novel subgroup of metallo-β-lactamases [PDF]

FEMS Microbiology Letters, 1996
AsbM1, a carbapenem-hydrolyzing beta-lactamase produced by Aeromonas sobria AER 14M, was purified chromatographically, with anion exchange chromatography performed in the absence of Zn2+. The molecular mass of AsbM1 was approximately 34,000; the isoelectric point was 9.1.
Y, Yang, K, Bush
openaire   +2 more sources

Prevalence and detection of Stenotrophomonas maltophilia carrying metallo-β-lactamase blaL1 in Beijing, China [PDF]

Frontiers in Microbiology, 2014
Intrinsic β-lactam resistance in Stenotrophomonas maltophilia is caused by bla L1 and/or bla L2, a kind of metallo-β-lactamase with a broad substrate spectrum including carbapenems. A rapid and sensitive molecular method for the detection of bla L1 in clinical samples is needed to guide therapeutic treatment. In present study, we first described a loop-
Zhan eYang, Wei eLiu, Qian eCui, Qian eCui, Wen Kai Niu, Huan eLi, Xiang Na Zhao, Xiao eWei, Xue Song Wang, Si Mo Huang, De Rong Dong, Si Jing Lu, Chang Qing Bai, Yan eLi, Liu Yu Huang, Jing eYuan   +15 more
openaire   +3 more sources

Detection of metallo-β-lactamase gene blaIMP of Escherichia coli clinical isolates in Sanglah General Hospital Bali

Indonesia Journal of Biomedical Science, 2019
Background: Escherichia coli belong to the family of Enterobacteriaceae that are responsible as one of the leading cause of nosocomial infections. The emergence of Carbapenem-resistant Enterobacteriaceae presents therapeutic challenges for clinicians on choosing the correct type of antibiotics to prescribe.
Muhammad Ardi Afriansyah, Ni Nyoman Sri Budayanti, Komang Januartha Putra Pinatih   +2 more
openaire   +1 more source

First case of New Delhi metallo-β-lactamase in Klebsiella pneumoniae from Ecuador: An update for South America [PDF]

International Journal of Infectious Diseases, 2017
To describe a clinical case of Klebsiella pneumoniae harboring a New Delhi metallo-β-lactamase (NDM) plasmid in Ecuador and to present a map of reports of NDM isolates in South America.The modified Hodge test, carbapenem inactivation method, imipenem-EDTA disk method (synergy), and Rapidec Carba NP test were used to identify antibiotic resistance ...
Daniel Romero-Alvarez, Jorge Reyes, Viviana Quezada, Carolina Satán, Nelson Cevallos, Sofía Barrera, Gabriel Trueba, Luis E. Escobar, José E. Villacís   +8 more
openaire   +3 more sources

Phenotypic Characterization of Multidrug-resistant Escherichia Coli with Special Reference to Extended-spectrum-beta-lactamases and Metallo-beta-lactamases in a Tertiary Care Center

Journal of Nepal Medical Association, 2015
Introduction: The increasing reports on extended-spectrum-beta-lactamase and metallo-betalactamase producing Escherichia coli have addressed a potential threat to global health since it is found to be highly resistance to most of the currently available ...
Basudha Shrestha, Shovita Shrestha, Shyam Kumar Mishra, Hari Prasad Kattel, Tatsuya Tada, Hiroshi Ohara, Teruo Kirikae, Basista Prasad Rijal, Jeevan Bahadur Sherchand, Bharat Mani Pokhrel   +9 more
doaj   +3 more sources

Molecular characterization ofbla_IMP-5, a new integron-borne metallo-β-lactamase gene from anAcinetobacter baumanniinosocomial isolate in Portugal [PDF]

FEMS Microbiology Letters, 2002
Acinetobacter baumannii 65FFC, an imipenem-resistant clinical strain, isolated from the urine of a patient at the Coimbra University Hospital, Portugal, in 1998, produced a metallo-beta-lactamase with a calculated pI 9.3. The isolate was highly resistant to penicillins, broad-spectrum cephalosporins, including ceftazidime, ceftriaxone, cefepime ...
Da Silva, GJ, Correia, M, Vital, C, Ribeiro, G, Sousa, JC, Leitao, R, Peixe, L, Duarte, A   +7 more
openaire   +3 more sources

Molecular heterogeneity ofbla_VIM-2-containing integrons fromPseudomonas aeruginosaplasmids encoding the VIM-2 metallo-β-lactamase [PDF]

FEMS Microbiology Letters, 2001
A bla(VIM-2) metallo-beta-lactamase determinant, identical to that previously identified in Pseudomonas aeruginosa COL-1 isolate from a French hospital, was detected on a 28-kb plasmid carried by a nosocomial isolate of P. aeruginosa from Verona, Italy.
PALLECCHI L., RICCIO M. L., DOCQUIER J. D., FONTANA R., ROSSOLINI G. M.   +4 more
openaire   +4 more sources

New Delhi Metallo-β-Lactamase–producing Enterobacteriaceae, United States

Emerging Infectious Diseases, 2013
We characterized 9 New Delhi metallo-β-lactamase–producing Enterobacteriaceae (5 Klebsiella pneumoniae, 2 Escherichia coli, 1 Enterobacter cloacae, 1 Salmonella enterica serovar Senftenberg) isolates identified in the United States and cultured from 8 ...
J. Kamile Rasheed, Brandon Kitchel, Wenming Zhu, Karen F. Anderson, Nancye C. Clark, Mary Jane Ferraro, Patrice Savard, Romney M. Humphries, Alexander J. Kallen, Brandi M. Limbago   +9 more
doaj   +1 more source

Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data

Microbiome, 2017
Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and ...
Fanny Berglund, Nachiket P. Marathe, Tobias Österlund, Johan Bengtsson-Palme, Stathis Kotsakis, Carl-Fredrik Flach, D G Joakim Larsson, Erik Kristiansson   +7 more
doaj   +1 more source