The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop [PDF]
, 2018 Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria.
Alzari, Pedro M. +10 more
core +1 more source
Journal of Nepal Medical Association, 2015 Introduction: The increasing reports on extended-spectrum-beta-lactamase and metallo-betalactamase producing Escherichia coli have addressed a potential threat to global health since it is found to be highly resistance to most of the currently available ...
Basudha Shrestha +9 more
doaj +3 more sources
First case of New Delhi metallo-β-lactamase in Klebsiella pneumoniae from Ecuador: An update for South America [PDF]
International Journal of Infectious Diseases, 2017 To describe a clinical case of Klebsiella pneumoniae harboring a New Delhi metallo-β-lactamase (NDM) plasmid in Ecuador and to present a map of reports of NDM isolates in South America.The modified Hodge test, carbapenem inactivation method, imipenem-EDTA disk method (synergy), and Rapidec Carba NP test were used to identify antibiotic resistance ...
Daniel Romero-Alvarez +8 more
openaire +3 more sources
Molecular heterogeneity ofblaVIM-2-containing integrons fromPseudomonas aeruginosaplasmids encoding the VIM-2 metallo-β-lactamase [PDF]
FEMS Microbiology Letters, 2001 A bla(VIM-2) metallo-beta-lactamase determinant, identical to that previously identified in Pseudomonas aeruginosa COL-1 isolate from a French hospital, was detected on a 28-kb plasmid carried by a nosocomial isolate of P. aeruginosa from Verona, Italy.
PALLECCHI L. +4 more
openaire +4 more sources
Motion of the Zinc Ions in Catalysis by a Dizinc Metallo-β-Lactamase [PDF]
, 2009 We report rapid-freeze-quench X-ray absorption spectroscopy of a dizinc metallo-β-lactamase (MβL) reaction intermediate. The Zn(II) ions in the dinuclear active site of the S.
Bennett, Brian +4 more
core +2 more sources
Presence of VIM-positive pseudomonas species in chickens and their surrounding environment [PDF]
, 2017 Metallo-β-lactamase gene blaVIM was identified on the chromosome of four Pseudomonas sp. isolates from a chicken farm, including one Pseudomonas aeruginosa isolate from a swallow (Yanornis martini), one Pseudomonas putida isolate from a fly, and two P ...
Lei, Lei +10 more
core +1 more source
New Delhi Metallo-β-Lactamase–producing Enterobacteriaceae, United States
Emerging Infectious Diseases, 2013 We characterized 9 New Delhi metallo-β-lactamase–producing Enterobacteriaceae (5 Klebsiella pneumoniae, 2 Escherichia coli, 1 Enterobacter cloacae, 1 Salmonella enterica serovar Senftenberg) isolates identified in the United States and cultured from 8 ...
J. Kamile Rasheed +9 more
doaj +1 more source
Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]
, 2018 Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J. +2 more
core +3 more sources
Microbiome, 2017 Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and ...
Fanny Berglund +7 more
doaj +1 more source
Imipenem resistance in clinical Escherichia coli from Qom, Iran [PDF]
, 2018 OBJECTIVE: The emergence of metallo-\u3b2-lactamase-producing Enterobacteriaceae is a worldwide health concern. In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and ...
Esmkhani, M. +5 more
core +1 more source