Results 61 to 70 of about 58,396 (229)

A promiscuous ancestral enzyme´s structure unveils protein variable regions of the highly diverse metallo-β-lactamase family

Communications Biology, 2021
The metallo-β-lactamase fold is an ancient protein structure present in numerous enzyme families responsible for diverse biological processes. The crystal structure of the hyperthermostable crenarchaeal enzyme Igni18 from Ignicoccus hospitalis was solved
Pablo Pérez-García, S. Kobus, C. Gertzen, A. Hoeppner, N. Holzscheck, C. Strunk, H. Huber, K. Jaeger, H. Gohlke, F. Kovačić, S. Smits, W. Streit, J. Chow   +12 more
semanticscholar   +1 more source

Complete genome sequence of the clinical strain Acinetobacter baumannii R2090 Carrying the chromosomally encoded Metallo-β-Lactamase Gene blaNDM-1 [PDF]

, 2015
Acinetobacter baumannii is an emerging human pathogen causing nosocomial and community-acquired infections. Here, we present the complete genome sequence of the clinical A.
Krahn, Thomas, Maus, Irena, Nordmann, Patrice, Poirel, Laurent, Pühler, Alfred, Schlüter, Andreas, Wibberg, Daniel, Winkler, Anika   +7 more
core   +1 more source

Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

Nature Communications, 2018
Drug-resistant superbugs pose a huge threat to human health. Infections by Enterobacteriaceae producing metallo-β-lactamases (MBLs), e.g., New Delhi metallo-β-lactamase 1 (NDM-1) are very difficult to treat.
Runming Wang, Tsz-pui Lai, P. Gao, Hongmin Zhang, P. Ho, Patrick C Y Woo, Guixing Ma, R. Kao, Hongyan Li, Hongzhe Sun   +9 more
semanticscholar   +1 more source

Molecular epidemiological survey of bacteremia by multidrug resistant Pseudomonas aeruginosa: the relevance of intrinsic resistance mechanisms. [PDF]

PLoS ONE, 2017
The bacterial factors associated with bacteremia by multidrug-resistant and extensively drug-resistant P. aeruginosa, including overexpression of efflux pumps, AmpC overproduction, and loss/alteration of the OprD porin in isolates that are non-Metallo-β ...
Raquel Cristina Cavalcanti Dantas, Rebecca Tavares E Silva, Melina Lorraine Ferreira, Iara Rossi Gonçalves, Bruna Fuga Araújo, Paola Amaral de Campos, Sabrina Royer, Deivid William da Fonseca Batistão, Paulo Pinto Gontijo-Filho, Rosineide Marques Ribas   +9 more
doaj   +1 more source

Clinical Evolution of New Delhi Metallo-β-Lactamase (NDM) optimizes resistance under Zn(II) Deprivation [PDF]

, 2018
Carbapenem-resistant Enterobacteriaceae (CRE) are rapidly spreading and taking a staggering toll on all health care systems, largely due to the dissemination of genes coding for potent carbapenemases.
Bahr, Guillermo, Bethel, Christopher R., Bonomo, Robert A., Gonzalez, Lisandro Javier, Vila, Alejandro Jose, Vitor Horen, Luisina   +5 more
core   +1 more source

MOESM5 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 5: Table S4. Potential Virulence factors identified in the Chryseobacterium indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Presence of New Delhi metallo-β-lactamase gene (NDM-1) in a clinical isolate of Acinetobacter junii in Argentina [PDF]

, 2016
Here we report the presence of a clinically significant A. junii blaNDM-1 positive in a 38-year-old woman who was admitted to the emergency department with a fever and leg ulcers with signs of infection.
Almuzara, Marisa, Barberis, Claudia, Cittadini, Roxana, Del Castillo M,, Lazzaro, T., Montaña, Sabrina Daiana, Ramírez, M. S., Uong, S., Vay, Carlos Alberto   +8 more
core   +1 more source

Additional file 2: of Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: assessment by a novel clinical tool

, 2019
Updated Charlson index score. (DOCX 14 kb)
Persoon, Marjolein, Holt, Anne Voor In, Meer, Maurits, Bokhoven, Karen, Gommers, Diederik, Vos, Margreet, JuliĂŤtte Severin   +6 more
openaire   +1 more source

Extensively drug-resistant New Delhi metallo-β-lactamase–encoding bacteria in the environment, Dhaka, Bangladesh, 2012 [PDF]

, 2015
Carriage of the New Delhi metallo-β-lactamase variant 1 (NDM-1) enables drug resistance to move between communities and hospitals. In Bangladesh, we found the blaNDM-1 gene in 62% of environmental waters and in fermentative and nonfermentative gram ...
Bugert, Joachim J., Nizam, Syed A., Toleman, Mark A.   +2 more
core   +2 more sources

MOESM6 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 6: Table S5. Four conjugative transposon gene clusters in the Chryseobacterium indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source