Results 101 to 110 of about 838,128 (221)

Utilization of Colistin for Treatment of Multidrug-Resistant Pseudomonas aeruginosa

Canadian Journal of Infectious Diseases and Medical Microbiology, 2008
BACKGROUND: Colistin is uncommonly used in clinical practice; however, the emergence of multidrug-resistant organisms has rekindled interest in this potentially toxic therapeutic option.
Deana M Sabuda, Kevin Laupland, Johann Pitout, Bruce Dalton, Harvey Rabin, Thomas Louie, John Conly   +6 more
doaj   +1 more source

A Study of Metallo Beta Lactamase Producing Clinical Isolates of Pseudomonas aeruginosa

Online Journal of Health & Allied Sciences, 2014
Introduction: The emergence and rapid spread of multidrug resistant Pseudomonas aeruginosa causing nosocomial infections is a great concern worldwide.
Mohite SL, Ghorpade MV
doaj  

Predominance of OXA-48 carbapenemase-producing Klebsiella pneumoniae strains in tertiary hospital in Sarajevo, Bosnia and Herzegovina

Biomolecules & Biomedicine
Klebsiella pneumoniae, a member of the Enterobacteriaceae family, demonstrates an increasing trend of resistance to carbapenems and is a common cause of both hospital- and community-acquired infections.
Amela Dedeić Ljubović, Đana Granov, Edina Zahirović, Azra Čamdžić, Adis Muhić, Irma Salimović Bešić   +5 more
doaj   +1 more source

Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate

, 1999
Production of a metallo-beta-lactamase activity was detected in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate (isolate VR-143/97) from an Italian inpatient at the Verona University Hospital (northern Italy).
G. Amicosante, CORNAGLIA, Giuseppe, G. M. Rossolini, FONTANA, Roberta, M. L. Riccio, L. Lauretti, MAZZARIOL, Annarita   +6 more
core   +1 more source

Molecular Epidemiology of Pseudomonas aeruginosa Isolated from Burn Patients

Armaghane Danesh Bimonthly Journal, 2014
Background & aim: Because of emerging multi-drug resistance (MDR) Pseudomonas aeruginosa strains, treatment of burn patients infected by this bacterium is difficult.
m Anvarinejad, a Japoni, n Rafaatpour, a Alipour, p Abbasi, m Shahidi, j Mardaneh   +6 more
doaj  

Comparing the activity of broad-spectrum beta-lactams in combination with aminoglycosides against VIM-producing Enterobacteriaceae

Microbiology Spectrum
Metallo-beta-lactamase (MBL)-producing carbapenem-resistant Enterobacteriaceae (CRE) infections continue to pose a serious threat to healthcare. Due to their unique active site, MBLs evade the activity of many novel beta-lactam/beta-lactamase inhibitor ...
Justin A. Clark, David S. Burgess
doaj   +1 more source

New leads of metallo-beta-lactamase inhibitors from structure-based pharmacophore design

, 2006
We have applied pharmacophore generation, database searching, docking methodologies, and experimental enzyme kinetics to discover new structures for design of di-zinc metallo-beta-lactamase inhibitors. Based on crystal structures of class B1 metallo-beta-
Adolph, Hans-Werner, Olsen, Lars, Jost, Sandra, Jørgensen, Flemming Steen, Hemmingsen, Lars, Pettersson, Ingrid   +5 more
core   +1 more source

Synergistic combination of ceftazidime and avibactam with Aztreonam against MDR Klebsiella pneumoniae in ICU patients

Scientific Reports
The proliferation of multidrug-resistant, metallo-beta-lactamase-producing Klebsiella pneumoniae (MBL-producing K. pneumoniae) poses a major threat to public health resulting in increasing treatment costs, prolonged hospitalization, and mortality rate ...
Sally Khattab, Aya Mohamed Askar, Hidi A. A. Abdellatif, Amira A. A. Othman, Amal H. Rayan, Hasnaa Azab   +5 more
doaj   +1 more source

Antibiotic Resistance: Mono- and Dinuclear Zinc Complexes as Metallo-${\beta}$-Lactamase Mimics

, 2006
Biomimetic systems containing one or two zinc(II) ions supported by phenolate ligands were developed as functional mimics of metallo-beta-lactamase. These complexes were shown to catalytically hydrolyze beta-lactam substrates, such as oxacillin and ...
Tamilselvi, A, Nethaji, Munirathinam, Mugesh, G   +2 more
core  

Complete sequence of broad-host-range plasmid pNOR-2000 harbouring the metallo-beta-lactamase gene blaVIM-2 from Pseudomonas aeruginosa

, 2013
Bonnin RA, Poirel L, Nordmann P, et al. Complete sequence of broad-host-range plasmid pNOR-2000 harbouring the metallo-beta-lactamase gene blaVIM-2 from Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy.
Bonnin, R. A., Wibberg, Daniel, Poirel, L., Nordmann, P., Schlüter, Andreas ; https://orcid.org/, Eikmeyer, Felix Gregor ; https://orcid.org/, Pühler, Alfred ; https://orcid.org/   +6 more
core   +1 more source