Results 91 to 100 of about 838,128 (221)

Prevalence of metallo-beta-lactamase enzyme and patern of antibiotic resistance in Klebsiella pnomoniae isolated from patients with urinary tract infection in Qom city during 2013-2014

Fiyz̤, 2017
Bachground: Klebsiella pnomoniae is one of the most important etiologic agents of urinary tract infection (UTI). An increasing occurrence of antimicrobial resistance among uropathogenic bacterial isolates has complicated the treatment process. The aim of
Rohollah Khodadadian, Ahmad Khorshidi , Mahmoud Safari, Hamid Reza Gilasi   +3 more
doaj  

Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1

, 2017
Background. The emergence of bacterial strains resistant to available antibiotic armamentarium is nowadays a pressing issue in clinical therapy. Among the several mechanisms of bacterial resistance, the rapid evolution and spread of carbapenemases, β ...
Cross, Simon, Perilli, Mariagrazia, Celenza, Giuseppe, Cendron, Laura, TONDI, Donatella, Bellio, Pierangelo, SPYRAKIS, FRANCESCA, Marcoccia, Francesca   +7 more
core  

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

, 2008
The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM.
Lassaux, Patricia, Huting, Rebekka, Galleni, Moreno, Schofield, Christopher J., Frère, Jean-Marie, Lienard, Benoit M. R., Rebekka Hüting (2454799), Benoît M. R. Liénard (2454802), Patricia Lassaux (551037), Christopher J. Schofield (233097), Moreno Galleni (330047), Jean-Marie Frère (461305)   +11 more
core   +1 more source

A fatal case of peritonitis caused by Dysgonomonas capnocytophagoides harboring the novel metallo-beta-lactamase gene blaDYB-1

International Journal of Infectious Diseases
Dysgonomonas capnocytophagoides shows multidrug resistance to antibiotics and causes opportunistic infections in immunocompromised hosts. The drug resistance mechanisms of D. capnocytophagoides have not yet been identified.
Kazuo Imai, Masahiro Kodana, Ryuha Omachi, Tsutomu Inoue, Hirokazu Okada, Takuya Maeda   +5 more
doaj   +1 more source

Zinc Beta-lactamase superfamily

, 2013
peer reviewedThe metallo-beta-lactamase superfamily was first defined in 1997 on the basis of a sequence alignment. The members of this superfamily are characterized by the presence of a common alpha-beta-beta-alpha fold and share five conserved motifs ...
Carine Bebrone, Bebrone, Carine
core   +1 more source

Phenotypic identification of Metallo-ß- lactamase resistance Gram negative bacteria from a clinical specimen in Sidama, Ethiopia.

PLoS ONE
BackgroundMetallo-beta lactamase resistance is one of the carbapenem resistances that worsen the world nowadays. A new variant of carbapenem-resistant has only limited reports from Africa including Ethiopia.
Tsegaye Alemayehu, Wondwesson Abera, Musa Mohammed Ali, Bethelihem Jimma, Henok Ayalew, Limenih Habte, Frezer Teka, Demissie Asegu   +7 more
doaj   +1 more source

Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales

Infection and Drug Resistance, 2021
Xing Tan,1 Hwan Seung Kim,1 Kimberly Baugh,2 Yanqin Huang,1 Neeraja Kadiyala,1 Marisol Wences,1 Nidhi Singh,1 Eric Wenzler,1 Zackery P Bulman1 1Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA ...
Tan X, Kim HS, Baugh K, Huang Y, Kadiyala N, Wences M, Singh N, Wenzler E, Bulman ZP   +8 more
doaj  

Incidence of Klebsiella pneumoniae producing Metallo Beta-Lactamase (MBL) at RSUP Dr. Wahidin Sudirohusodo Makassar [PDF]

, 2022
Bacterial resistance to antibiotic is one of the factors triggering infection therapy failure. This study was conducted to determine the prevalence of carbapenem-resistance Klebsiella pneumoniae infection and the phenotype of carbapenem-resistant Metallo-
Djide, Natsir, Arif, Mansyur, Hamdani, Muhammad Jen   +2 more
core  

Emergence of Proteus mirabilis carrying the bla(VIM-1) metallo-beta-lactamase gene

, 2006
Seven genetically related Proteus mirabilis clinical isolates from a hospital in Thessaloniki, Greece, exhibited decreased susceptibility to imipenem and carried a bla(VIM-1) metallo-beta-lactamase gene. PCR mapping revealed that bla(VIM-1) was part of a
Tsorlini, H., Polemis, M., Tzouvelekis, L. S., Vatopoulos, A. C., Katsifa, H., Vourli, S., Kontodimou, A.   +6 more
core   +1 more source

Identification, Characterization, and Formulation of a Novel Carbapenemase Intended to Prevent Antibiotic-Mediated Gut Dysbiosis

Microorganisms, 2019
Antibiotics can damage the gut microbiome leading to opportunistic infections and the emergence of antibiotic resistance. Microbiome protection via antibiotic inactivation in the gastrointestinal (GI) tract represents a strategy to limit antibiotic ...
Sheila Connelly, Todd Parsley, Hui Ge, Michael Kaleko   +3 more
doaj   +1 more source