Results 71 to 80 of about 838,128 (221)

Metagenomics Reveals Microbial Community Shifts Associated With Contrasting Anthropogenic Impacts in Freshwater Sources of A Coastal Protected Area in Southeastern Brazil

Water Environment Research, Volume 98, Issue 9, September 2026.
Metagenomics revealed distinct anthropogenic signatures in the microbiome of freshwater sources on Marambaia Island, supported by the Anthropogenic Impact Index (AII). Impacted sites showed lower microbial diversity, enrichment of fecal‐associated taxa, and 14 antimicrobial resistance genes, whereas conductivity, salinity, and turbidity explained 88.1%
Bruna Barbosa de Paula, Marize Pereira Miagostovich, Camille Ferreira Mannarino, André Vinicius Costa Ribeiro, Natália Maria Lanzarini, Carla Santos de Oliveira, Shênia Patrícia Corrêa Novo   +6 more
wiley   +1 more source

Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing Salmonella enterica serovar Typhimurium isolated from a case of fatal burn wound infection

Infection and Drug Resistance, 2018
Kokila Banerjee,1 Priyadharshini Sekar,2 Padma Krishnan,2 Alice Rebecca Wattam,3 Subhendu Roy,1 John P Hays,4 Godfred A Menezes5 1Department of Microbiology, Drs Tribedi and Roy Diagnostic Laboratory, Kolkata, India; 2Department of Microbiology, Dr ALM ...
Banerjee K, Sekar P, Krishnan P, Wattam AR, Roy S, Hays JP, Menezes GA   +6 more
doaj  

A Four‐Center Study on the Activity of Aztreonam and Aztreonam‐Avibactam Combination Against Clinical Isolates of Gram‐Negative Bacilli Producing Representatives of Ambler Class A, B, C or D β‐Lactamases

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT We aimed to investigate the activity of aztreonam and aztreonam‐avibactam combination against gram‐negative bacilli producing different types of β‐lactamases. Activity of aztreonam and aztreonam‐avibactam against 166 isolates (33 AmpC‐producing, 33 ESBL‐producing, 66 carbapenemase‐producing Enterobacterales, 34 metallo‐β‐lactamase‐producing P.
Gizem İnce Ceviz, Hasan Cenk Mirza, Aylin Üsküdar Güçlü, Özlem Öğüç Şanlı, Özlem Kurt Azap, Banu Sancak, Elvan Hortaç İştar, Ahmet Başustaoğlu   +7 more
wiley   +1 more source

In vitro and in silico screening of Klebsiella pneumoniae new Delhi metallo-β-lactamase-1 inhibitors from endophytic Streptomyces spp.

, 2021
The increase in drug resistance over the last two decades is a big threat in health care settings. More importantly, the dissemination of carbapenem-resistant Enterobacteriaceae is the major threat to public health with an increase in morbidity and ...
Aathithya Diaz (11572536), Sudarshan Singh Rathore (6406109), Adithya Conjeevaram Gopal (11572539), Jayapradha Ramakrishnan (6406115), Lalitha Cheepurupalli (6406106), Vigneshwar Ramakrishnan (3388904)   +5 more
core   +1 more source

Restoring Meropenem Activity Against VIM‐1‐Producing Klebsiella pneumoniae Through Zinc‐Binding Ligands

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Approved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Chiara Ragusa, Ruqaiya Khalil, Valentina Giglio, Kaveh Eskandari, Fraser J. Scott, Attilio V. Vargiu, Graziella Vecchio   +6 more
wiley   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari, Sepideh Elyasi, Farshad Abedi   +2 more
wiley   +1 more source

Metallo beta lactamase producing Pseudomonas aeruginosa and Acinetobacter baumannii

Indian Journal of Medical Microbiology, 2011
This study aims in identifying MBLs particularly Zn requiring Molecular Class B enzymes produced by Pseudomonas aeruginosa and Acinetobacter baumannii .The resistance by these organisms are in a rise against all antibiotics including carbapenems and no prescribed CLSI guidelines is available for detecting them.
John, S, Balagurunathan, R
openaire   +2 more sources

Structural and kinetic studies on beta-lactamase mechanism and inhibition [PDF]

, 2018
Beta-lactamases constitute one of the most prevalent identified mechanisms of bacterial resistance to the beta-lactam antibiotics. These enzymes are broadly divided into two mechanistic subclasses, the serine-beta-lactamases and the metallo-beta ...

core   +1 more source

beta-lactamase-inhibitors

, 2022
Archive of beta-lactamase-inhibitors containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875), Silvia Gervasoni (6169202), Andrea Bosin (6743129), Helen I. Zgurskaya (3093648), Attilio Vittorio Vargiu (2358538), Paolo Ruggerone (247673)   +5 more
core   +1 more source

Identification and phylogenetic analysis of carbapenemase genes from clinical strains of Klebsiella pneumoniae

Journal of Infection in Developing Countries
Introduction: Klebsiella pneumoniae is an encapsulated Gram-negative bacterium that is responsible for numerous infections in healthcare facilities worldwide and is frequently isolated. The World Health Organization has listed K.
Boukaré Kaboré, Ganamé A Ouédraogo, Henri S Ouédraogo, Hama Cissé, Oumarou Zongo, Koudbi J Zongo, Boukaré Zeba, Idrissa Sanou, Aly Savadogo   +8 more
doaj   +1 more source