Results 61 to 70 of about 838,128 (221)

High Expression of Metallo-β-Lactamase Contributed to the Resistance to Carbapenem in Clinical Isolates of Pseudomonas aeruginosa from Baotou, China

Infection and Drug Resistance, 2020
Yanfeng Xu,1,* Haiying Niu,1,* Tongping Hu,2 Lixia Zhang,2 Shanna Su,1 Huijie He,1 Huimin Wang,1 Dong Zhang1 1Department of Pulmonary Medicine, The First Affiliated Hospital of Baotou Medical College, Baotou, People’s Republic of China; 2Department ...
Xu Y, Niu H, Hu T, Zhang L, Su S, He H, Wang H, Zhang D   +7 more
doaj  

Iran's Escherichia coli AMR Landscape (2010–2025): A One Health Systematic Review and Meta‐Analysis

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
This One Health systematic review and meta‐analysis of 368 studies (2010–2025) reveals that 47.2% of E. coli isolates in Iran are ESBL‐producers, with alarming resistance to penicillins, cephalosporins, and fluoroquinolones. Critically, resistance to last‐resort antibiotics—colistin and ertapenem—is significantly increasing over time.
Arezoo Dehghan, Mina Arabian, Zahra Tahmasebi, Aliasghar Fakhri‐Demeshghieh, Neda Baseri, Ehsan Mostafavi, Farzad Badmasti, Faranak Abnaroodhelleh, Arash Seifi, Fahimeh Bagheri Amiri   +9 more
wiley   +1 more source

Position Effect Variegation of Penicillium rubens Genome and Application in Heterologous Production of the Plant‐Derived Anthraquinone Physcion

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
This study constructed a PiggyBac transposon mediated mutagenesis system which was used to investigate the genomic position effect on heterologous production of physcion in Penicillium ruben. This PB platform enables efficient genetic engineering for secondary metabolite production. ABSTRACT The filamentous fungus Penicillium rubens is well known as an
Meng Wu, Yushi Fu, Linqin Tang, Yongpeng Yao, Yuanyuan Pan, Gang Liu   +5 more
wiley   +1 more source

Antibiogram of Extended Beta and Metallo-beta-lactamase E. coli O157:H7 Isolated from Pigs and Periwinkles sold in Rivers State

, 2022
The emergence of multi-drug resistant and Extended Beta-lactamase producing E. coli O157:H7 is a general public health problem. Food samples of animal origin are undoubtedly the reservoirs of MDR which are in most cases transmitted to humans.
Felicia O., Osakuade,, Ngozi N., Odu,, Osakuade, Felicia O., Odu, Ngozi N.   +3 more
core   +1 more source

Detecting Metallo-Beta-Lactamase (MBL) Genes of blaSPM1, blaIMP1, blaIMP2, blaVIM 1, and blaVIM in Isolated Pseudomonas aeruginosa from Clinical Samples and its Antibiotic Resistance

مجله دانشکده پزشکی اصفهان, 2015
Background: Pseudomonas aeruginosa is one of the important factors for nosocomial infections, particularly in patients with impaired immune systems and children.
Mahdi Rouhi-Biroon, Kumarss Amini, Mahdi Parviz   +2 more
doaj  

Interpretation of Key Updates in the 36th Edition of Clinical and Laboratory Standards Institute M100 Standard

iLABMED, Volume 4, Issue 3, Page 133-138, September 2026.
ABSTRACT The Clinical and Laboratory Standards Institute M100 document serves as a cornerstone standard for clinical microbiology laboratories in China. Maintaining the scientific rigor of its predecessors, the 36th edition incorporates updated epidemiological cutoff values, pharmacokinetic/pharmacodynamic data, and clinical efficacy evidence to revise
Kanghong Xu, Qi Wang, Hui Wang
wiley   +1 more source

Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases

iMetaOmics, Volume 3, Issue 3, September 2026.
An integrative metagenomic framework combining sequence, structural, and functional inference reveals a phylogenetically diverse and structurally conserved repertoire of putative beta‐lactamases across Antarctic soil microbiomes, with predominance of class A and subclass B3 enzymes and limited but detectable associations with mobile genetic elements ...
José Coche‐Miranda, Patricio Arros, Nicolás Canales, Camilo Berríos‐Pastén, Gastón Azziz, Rosalba Lagos, Julieta Orlando, Francisco P. Chávez, Andrés E. Marcoleta   +8 more
wiley   +1 more source

Metallo-β-lactamase and genetic diversity of Pseudomonas aeruginosa in intensive care units in Campo Grande, MS, Brazil

Brazilian Journal of Infectious Diseases, 2011
Infection by Pseudomonas aeruginosa has spread worldwide, with limited options for treatment. The purpose of this study was to investigate metallo-β-lactamase-producing P.
Ana Claudia Souza Rodrigues, M.D., Marilene Rodrigues Chang, Ph.D., Gabriela Dorn Nóbrega, Mayara Souza Rodrigues, Nadia Cristina Pereira Carvalho, Beatriz Garcia Gomes, Dênio Lopes de Almeida, Karyne Rangel Carvalho, M.D., Marise Dutra Asensi, Ph.D.   +8 more
doaj   +1 more source

A protein of the metallo-hydrolase/oxidoreductase superfamily with both beta-lactamase and ribonuclease activity is linked with translation in giant viruses

Scientific Reports, 2020
Proteins with a metallo-beta-lactamase (MBL) fold have been largely studied in bacteria in the framework of resistance to beta-lactams, but their spectrum of activities is broader.
Philippe Colson, Lucile Pinault, Said Azza, Nicholas Armstrong, Eric Chabriere, Bernard La Scola, Pierre Pontarotti, Didier Raoult   +7 more
doaj   +1 more source

Investigating enzyme function by geometric matching of catalytic motifs

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The rapidly growing universe of predicted protein structures offers opportunities for data driven exploration but requires computationally scalable and interpretable tools. We developed a method to detect catalytic features in protein structures, providing insights into enzyme function and mechanism.
Raymund E. Hackett, Ioannis G. Riziotis, Martin Larralde, António J. M. Ribeiro, Georg Zeller, Janet M. Thornton   +5 more
wiley   +1 more source