Results 101 to 110 of about 811,638 (168)

Genetic characterization of CTX-M-15, AmpC, and metallo-β-lactamase genes among clinical Klebsiella pneumoniae isolates in a tertiary-care hospital [PDF]

Journal of Krishna Institute of Medical Sciences University
Background: The co-existence of Extended-Spectrum β-Lactamases (ESBL), AmpC β-lactamases and Metallo-β-Lactamases (MBL) in Klebsiella pneumoniae limits therapeutic options and complicates infection control in tertiary-care settings.
Swarangi Kulkarni, Neetu Gupta, Kalpana Angadi, Vivekanand Jadhav, Savita Jadhav   +4 more
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Antibiotic Resistance in Klebsiella pneumoniae and Related Enterobacterales: Molecular Mechanisms, Mobile Elements, and Therapeutic Challenges

Antibiotics
Drug-resistant Klebsiella pneumoniae and related Enterobacterales represent an escalating global public health threat, increasingly limiting therapeutic options in both healthcare- and community-associated infections.
Veronika Zdarska, Gabriele Arcari, Milan Kolar, Patrik Mlynarcik   +3 more
doaj   +1 more source

INHIBITORS OF METALLO-BETA-LACTAMASES : WO/2018/215800

, 2018
The present invention relates to certain compounds that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them ...
BELFRAGE, Anna Karin,, LINDSTRÖM, Stefan, ANTONOV, Dmitry, BREM, Jürgen, SCHOFIELD, Christopher J, GISING, Johan, BRANDT, Peter   +6 more
core  

Interactions of biapenem with active-site serine and metallo-beta-lactamases.

, 1995
peer reviewedBiapenem, formerly LJC 10,627 or L-627, a carbapenem antibiotic, was studied in its interactions with 12 beta-lactamases belonging to the four molecular classes proposed by R. P. Ambler (Philos. Trans. R. Soc. Lond. Biol. Sci.
Setacci, D., PERILLI, MARIAGRAZIA, AMICOSANTE, Gianfranco, SEGATORE, Bernardetta, Felici, A., SETACCI, Domenico, Segatore, B., Oratore, A., Amicosante, G., Franceschini, N., Felici, A, FRANCESCHINI, Nicola, Galleni, Moreno, Stefani, S., Perilli, M., ORATORE, Arduino, Galleni, M.   +16 more
core   +1 more source

Prevalence of drug resistant Enterobacteriaceae in a Nepalese tertiary care hospital.

PLOS Global Public Health
Antimicrobial resistance in Enterobacteriaceae is an emerging global public health problem. Numerous studies have reported community-acquired AmpC beta-lactamase and extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in Nepal.
Anita Bhandari, Saroj Khatiwada, Aashish Sharma, Subhas Chandra Aryal, Raju Shrestha, Nabin Kishor Bimali, Binod Lekhak, Narayan Dutt Pant   +7 more
doaj   +1 more source

Current Trends in beta-Lactam Based beta-Lactamases Inhibitors

, 2011
The introduction of antibiotics to treat bacterial infections either by killing or blocking their growth has been accompanied by the development of resistance mechanism that allows the bacteria to survive and proliferate.
Biondi S, Qin WL, Panunzio M, Long S
core  

Metallo-β-Lactamases and Aptamer-Based Inhibition

, 2011
An evolution of antibiotic-resistant bacteria has resulted in the need for new antibiotics. β-Lactam based drugs are the most predominantly prescribed antibiotics to combat bacterial infections; however, production of β-lactamases, which catalyze the ...
Sara R. Schlesinger, Mieke Lahousse, Sung-Kun Kim, Taylor O. Foster, Taylor Foster, Sara Schlesinger, Mieke J. Lahousse   +6 more
core   +1 more source

Exploring New Delhi Metallo Beta Lactamases in Klebsiella pneumoniae and Escherichia coli: genotypic vs. phenotypic insights

Annals of Clinical Microbiology and Antimicrobials
Background Carbapenemase-producing Enterobacterales pose a serious clinical threat, particularly in high-burden settings of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae (CREK), where rapid detection tools are essential to aid patient ...
Noor Ul Ain, Linzy Elton, Zahra Sadouki, Timothy D. McHugh, Saba Riaz   +4 more
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Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors [Elektronisk resurs] [PDF]

Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-beta-lactamases is of particular concern as these bacterial enzymes dismantle most beta-lactam antibiotics,
Haffke, Paul,, Gulyas, Kinga Virag, Salamonsen, Daniel,, Andersson Rasmussen, Anna,, Prester, A., Xu, Z., Li, Jintian, Widersten, Mikael,, Leiros, Hanna-Kirsti Schroder,, Widersten, Mikael, Bosman, Robert, Tamasi, Viola, Salamonsen, D., Zhou, Liping, Schroder Leiros, Hanna-Kirsti, Zhou, Liping,, Gulyás, K., Rohde, Holger,, Rohde, H., Bartels, Kim,, Thoma, Johannes, Csala, Miklos,, Rasmussen, A., Schulz, Eike C., Bartels, Kim, Zhou, L., Schulz, Eike C.,, Salamonsen, Daniel, Deufel, F., Erdelyi, Mate, Bartels, K., Csala, Miklos, Li, J., Tamasi, Viola,, Widersten, M., Prester, Andreas,, Haffke, P., Gulyás, Kinga,, Li, Jintian,, Schulz, Eike, Rohde, Holger, Haffke, Paul, Tamási, V., Schulz, E., Andersson Rasmussen, Anna, Erdélyi, M., Thoma, Johannes,, Zhu, Weiliang,, Zhu, Weiliang, Erdélyi, Máté,, Prester, Andreas, Thoma, J., Gulyás, Kinga, Leiros, Hanna-Kirsti Schroder, Schroder Leiros, H., Xu, Zhijian, Bosman, Robert,, Bosman, R., Csala, M., Zhu, W., Deufel, Fritz, Deufel, Fritz,, Xu, Zhijian,   +62 more
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Prevalencia de metalo-β-lactamasas en Pseudomonas aeruginosa resistentes a carbapenemes en un Hospital Universitario de Buenos Aires Prevalence of metallo-β-lactamase in carbapenem resistant Pseudomonas aeruginosa at an University Hospital of Buenos Aires City

Revista Argentina de Microbiología, 2006
Se estudiaron 91 aislamientos de Pseudomonas aeruginosa resistentes a carbapenemes con el objetivo de conocer la prevalencia de metalo-β-lactamasas y evaluar la habilidad del ensayo de inhibición empleando discos de EDTA (1 µmol) en su detección. Se
G. Pagniez, M. Radice, A. Cuirolo, O. Rodríguez, H. Rodríguez, C. Vay, A. Famiglietti, G. Gutkind   +7 more
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