Results 81 to 90 of about 811,638 (168)

Breakthrough Advances in Beta-Lactamase Inhibitors: New Synthesized Compounds and Mechanisms of Action Against Drug-Resistant Bacteria

Pharmaceuticals
Beta-lactam drugs hold a central place in the antibacterial arsenal, and the production of beta-lactamases by drug-resistant bacteria has severely compromised the effectiveness of nearly all available beta-lactams.
Ya-Si Huang, Hong Zhou
doaj   +1 more source

Molecular characterization and clinical significance of New Delhi metallo-beta-lactamases-1 producing Escherichia coli recovered from a South Indian tertiary care hospital

Indian Journal of Pathology and Microbiology, 2015
Context: The increased rate of infection by New Delhi metallo-beta-lactamases-1 (NDM1) producing Escherichia coli is a major concern since they show a high rate of drug resistance and are responsible for mortality and morbidity. Aims: To characterize the
Arindam Ckakraborty, Prabha Adhikari, Shalini Shenoy, Shrikala Baliga, Gopalkrishna Bhat, Satish Rao, Dhanashree Biranthabail, Vishwas Saralaya   +7 more
doaj   +1 more source

Phenotypic characterization of beta-lactamases producing Gram-negative bacteria in a tertiary hospital, Nepal

Nepal Journal of Biotechnology, 2019
Infections caused by beta-lactamases producing Gram-negative bacteria are increasing, thus posing a challenge to the management of such infections.
Elina Maharjan, Pooja Shakya, Balkrishna Bhattachan, Bharat Prasad Baral, Dhiraj Shrestha   +4 more
doaj   +1 more source

Metallo-beta-lactamases of Pseudomonas aeruginosa--a novel mechanism resistance to beta-lactam antibiotics.

Folia Histochemica et Cytobiologica, 2008
Since about twenty years, following the introduction into therapeutic of news beta-lactam antibiotics (broad-spectrum cephalosporins, monobactams and carbapenems), a very significant number of new beta-lactamases appeared.
Dorota Olszańska, Marcin Zórawski, Tomasz Hauschild, Piotr Wieczorek, Paweł Sacha, Elzbieta Tryniszewska   +5 more
doaj   +1 more source

Coexistence of metallo-beta-lactamase-encoding genes in Pseudomonas aeruginosa

Indian Journal of Medical Research, 2017
Background & objectives: The emergence and rapid spread of carbapenem resistance mediated by metallo-beta-lactamase (MBL) in Pseudomonas aeruginosa is of major concern due to limited therapeutic options. This study was aimed at detecting the presence of MBL and its association with integrons in imipenem-resistant P ...
Mohanam, Lavanya, Menon, Thangam
openaire   +2 more sources

Discovery of potential inhibitors against New Delhi metallo-beta-lactamase-1 from natural compounds: in silico-based methods

, 2021
New Delhi metallo-beta -lactamase variants and different types of metallo-beta -lactamases have attracted enormous consideration for hydrolyzing almost all beta -lactam antibiotics, which leads to multi drug resistance bacteria.
Faghri, J., Mahnam, K., Sadeghi, P., Damavandi, M. S., Salari-jazi, A.   +4 more
core   +1 more source

Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France.

, 2010
International audienceA nationwide study aimed to identify the extended-spectrum beta-lactamases (ESBLs), metallo-beta-lactamases (MBLs), and extended-spectrum oxacillinases (ES-OXAs) in a French collection of 140 clinical Pseudomonas aeruginosa isolates
Barbara Dehecq, Didier Hocquet, Daniel Talon, Mariotte, Pierre, Renseigné, Non, Hocquet, Didier, Bertrand, Xavier, Talon, Daniel, Dehecq, Barbara, Xavier Bertrand, Pierre Mariotte, Plésiat, Patrick, Patrick Plésiat   +12 more
core   +1 more source

False Positive Phenotypic Detection of Metallo-Beta-Lactamases in Acinetobacter Baumannii

Acta Clinica Croatica, 2019
Phenotypic detection of metallo-β-lactamases (MBLs) in Acinetobacter (A.) baumannii is a serious challenge to clinical microbiologists. MBLs are inhibited by metal chelators such as ethylenediaminetetraacetic acid) (EDTA).
Branka Bedenić, Ranko Ladavac, Mirna Vranić-Ladavac, Nada Barišić, Natalie Karčić, Katherina Bernadette Sreter, Slobodan Mihaljević, Luka Bielen, Haris Car, Nataša Beader   +9 more
doaj   +1 more source

Gram-Negative Uropathogens in Diabetic Patients: A Study of Ampicillinase Cephalosporinase, Extended-Spectrum Beta-Lactamases, and Metallo Beta-Lactamases Producing Phenotypes

Journal of Pharmacy and Bioallied Sciences
Aim: This study aimed to identify Gram-negative uropathogens (GN-UP)-producing extended-spectrum beta-lactamases (ESBL), metallo-beta-lactamases (MBL), and AmpC enzymes in diabetic patients and to analyze their antibiotic resistance profiles.
Satish R Patil, G. S. Karande, Ravindra V. Shinde, Satyajeet K. Pawar   +3 more
doaj   +1 more source

Extended spectrum AmpC and metallo-beta-lactamases in Serratia and Citrobacter spp. in a disc approximation assay

Journal of Infection in Developing Countries, 2009
Objectives: This study aimed to develop a novel model for detection of extended spectrum beta-lactamase (ESBL), AmpC and metallo-beta-lactamase (MBL) producing Serratia and Citrobacter species using cefoperazone sulbactam as well as other inducer ...
Meher Rizvi, Nazish Fatima, Mohd. Rashid, Indu Shukla, Abida Malik, Aayesha Usman, Shireen Siddiqui   +6 more
doaj   +1 more source