Results 71 to 80 of about 811,638 (168)

Genomic Epidemiology of Multidrug‐Resistant Clinical Klebsiella pneumoniae From Pakistan

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Study design and bioinformatics workflow. Cohort selection and uniform workflow. ABSTRACT Background Antimicrobial‐resistant Klebsiella pneumoniae is a major clinical threat in Pakistan and the wider South Asian region, where genomic surveillance remains limited. We analyzed 122 publicly available human clinical K.
Hakeem Zada, Muhammad Qasim, Mubashir Hussain, Abdul Rehman, Hassan Naveed, Noor Bahadar, Najibullah Anwari   +6 more
wiley   +1 more source

Metallo-beta-lactamases and their biomimetic complexes

, 2014
In order to treat bacterial infections successfully in the future, the mechanism of action of metallo-beta-lactamases (M beta Ls) needs to be fully understood so that clinically useful inhibitors and new therapeutic approaches can be developed.
Schenk, Gerhard, Daumann, Lena J., Gahan, Lawrence R.   +2 more
core   +1 more source

Characterizing the role of porin mutations in susceptibility of beta lactamase producing Klebsiella pneumoniae isolates to ceftaroline and ceftaroline-avibactam

International Journal of Infectious Diseases, 2020
Objectives: Evaluate the role of porins in the susceptibility of Klebsiella pneumoniae to ceftaroline and ceftaroline-avibactam. Methods: Susceptibility to ceftaroline and ceftaroline-avibactam was tested by broth microdilution method in Klebsiella ...
Ali Khalid, Alicia Fajardo Lubián, Li Ma, Ruby C.Y. Lin, Jonathan R. Iredell   +4 more
doaj   +1 more source

The characterization of a new stabilized lactonase from the endophytic fungi Aspergillus pseudonomiae with anti‐bacterial and anti‐fungal properties

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Dor Ben Tovim, Olena Trofimyuk, Elon Yariv, Gali Prag, Livnat Afriat‐Jurnou   +4 more
wiley   +1 more source

Utility of phenotypic methods in detection of metallo-beta-lactamases in gram-negative bacteria

Journal of Marine Medical Society, 2020
Background: Metallo-beta-lactamases (MBLs)-producing Gram-negative bacilli (GNB) are one of the significant multidrug-resistant pathogens causing healthcare-associated infection (HAI) worldwide.
Dinesh Kumar Kalra, Sanjay Pratap Singh, Ajay Kumar Sahni, Naveen Grover, Mahadevan Kumar, Deepti Kalra   +5 more
doaj   +1 more source

Vibrio Community Structure Shapes the Diversity of Carbenicillin‐Hydrolysing Class A β‐Lactamase Circulating in European Coastal Environments

Environmental Microbiology, Volume 28, Issue 8, August 2026.
Vibrio communities shape carbenicillinase diversity in European coasts. Sediments serve as reservoirs of antibiotic‐resistant Vibrio alginolyticus, which can move into the water column and accumulate in bivalves. This spreads β‐lactamase resistance and raises human exposure risks to antibiotic‐resistant pathogenic Vibrio, especially as higher seawater ...
Berenice Reggiardo, Jamal Saad, Marie‐Agnès Travers, Yannick Labreuche, David Goudenège, Eve Toulza, Coralie Broquard, Karl B. Andree, Julia Mougin, Nicolas Argenta, Gaëlle Courtay, Juliette Pouzadoux, Océane Romatif, Audrey Caro, Dolors Furones, Luigi Vezzulli, Gianluca Corno, Andrea Di Cesare, Ignasi Gairin, Bruno Petton, K. Mathias Wegner, Caroline Montagnani, Viviane Boulo, Delphine Destoumieux‐Garzón   +23 more
wiley   +1 more source

Detection of New Delhi Metallo-beta-lactamase-1 among Pseudomonas aeruginosa isolated from adult and Pediatric patients in Iranian hospitals

, 2021
Gram-negative bacteria cause an alarming level of resistance to carbapenems by producing carbapenemases which can become a global epidemic. According to a report about Pseudomonas aeruginosa released by the World Health Organization in 2017, carbapenem ...
Ali Hashemi, Hesam Alizade, Fereshteh Ezadi, Fariba Naeimi Mazraeh, Mazraeh, F. N., Ali Hematian, Goudarzi, H., Hossein Goudarzi, Mehdi Goudarzi, Goudarzi, M., Alizade, H., Abdollah Ardebili, Ezadi, F., Hematian, A., Rad, Z.R., Hashemi, A., Zahra Riahi Rad, Mazraeh, F.N., Ardebili, A., Rad, Z. R., Zohreh Riahi Rad   +20 more
core   +1 more source

Detection and characterization of metallo beta lactamases producing Pseudomonas aeruginosa

Indian Journal of Medical Microbiology, 2010
This study was undertaken to evaluate phenotypic and genotypic methods for detection of Metallo-Beta-Lactamases (MBLs) among nosocomial Pseudomonas aeruginosa. Sixty one among 176 P. aeruginosa isolates, collected as part of a multicentric study (2005-2007), were evaluated for carbapenem resistance (CARB-R; resistant to either imipenem/meropenem) and ...
A, Manoharan, S, Chatterjee, D, Mathai
openaire   +2 more sources

Occurrence and Distribution of Environmental Pseudomonas aeruginosa From Hospitals in Bangladesh Reveals Diverse Strain Families, Multidrug Resistance, and Biofilm Formation

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Environmental reservoirs in Bangladeshi hospitals harbor phylogenetically diverse, multidrug‐resistant Pseudomonas aeruginosa with extensive biofilm‐forming capacity and class 1 integron‐associated resistance genes. These findings highlight hospital environments as persistent sources of antimicrobial resistance dissemination and underscore the need for
S. M. Kador, Tanay Chakrovarty, Khandaker Adil, Md. Mustak Ahmed, Md. Mohsin Kobir, Md. Hasanuzzaman, Mousufa Akter, Tanzima Sharmim Taowhid, Md. Tanvir Islam, Ovinu Kibria Islam   +9 more
wiley   +1 more source

Structural and kinetic studies on beta-lactamase mechanism and inhibition [PDF]

, 2018
Beta-lactamases constitute one of the most prevalent identified mechanisms of bacterial resistance to the beta-lactam antibiotics. These enzymes are broadly divided into two mechanistic subclasses, the serine-beta-lactamases and the metallo-beta ...

core   +1 more source