Results 51 to 60 of about 811,638 (168)

Position Effect Variegation of Penicillium rubens Genome and Application in Heterologous Production of the Plant‐Derived Anthraquinone Physcion

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
This study constructed a PiggyBac transposon mediated mutagenesis system which was used to investigate the genomic position effect on heterologous production of physcion in Penicillium ruben. This PB platform enables efficient genetic engineering for secondary metabolite production. ABSTRACT The filamentous fungus Penicillium rubens is well known as an
Meng Wu, Yushi Fu, Linqin Tang, Yongpeng Yao, Yuanyuan Pan, Gang Liu   +5 more
wiley   +1 more source

Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase [PDF]

, 2001
peer reviewedEuropena Training and Mobility of Researchers Network on Metallo-beta-Lactamases (grant no.
Luzzaro, F, Luzzaro, F., Francesco Luzzaro, Toniolo, A., Gian Maria Rossolini, Amicosante, G., Toniolo, A, Gianfranco Amicosante, Docquier, Jean-Denis, Rossolini, G. M., DOCQUIER, JEAN DENIS, Amicosante, G, Antonio Toniolo, ROSSOLINI, GIAN MARIA, Jean-Denis Docquier   +14 more
core   +1 more source

Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-beta-Lactamases [PDF]

, 2021
In an attempt to exploit the hydrolytic mechanism by which beta-lactamases degrade cephalosporins, we designed and synthesized a series of novel cephalosporin prodrugs aimed at delivering thiol-based inhibitors of metallo-beta-lactamases (MBLs) in a ...
van Westen, Gerard J. P.,, Bruchle, Nora C., Tehrani, Kamaleddin H. M. E.,, Jespers, Willem,, Martin, Nathaniel, I,, Jespers, Willem, Mashayekhi, Vida, van Haren, Matthijs J., van Haren, Matthijs J.,, Tehrani, Kamaleddin H. M. E., Voskuil, Koen, Pesce, Diego, Mashayekhi, Vida,, Bruchle, Nora C.,, Martin, Nathaniel, I, Wade, Nicola,, Wade, Nicola, Voskuil, Koen,, van Westen, Gerard J. P., Pesce, Diego,, Jespers, W., Pesce, D., Voskuil, K., Westen, G.J.P. van, Tehrani, K.H.M.E., Brüchle, N.C., Mashayekhi, V., Haren. M.J. van, Martin, N.I., Haren, M.J. van, Brüchle, N., Wade, N., Koen Voskuil, Willem Jespers, Nathaniel I. Martin, Kamaleddin H. M. E. Tehrani, Gerard J. P. van Westen, Vida Mashayekhi, Matthijs J. van Haren, Nicola Wade, Diego Pesce, Nora C. Brüchle   +41 more
core   +1 more source

Evaluation of Modified Rapid Carbapenem Inactivation Method (mrCIM) Combined with Rapid EDTA-Modified Carbapenem Inactivation Method (reCIM) to Detect Carbapenemase and Distinguish Metallo-Carbapenemase in Enterobacteriaceae Within Four Hours

Infection and Drug Resistance, 2020
Qiang Wei, Jide Sun, Zhu Wang, Li Yan, Chuanming Zhang, Xiuyu Xu Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Xiuyu XuDepartment of Laboratory
Wei Q, Sun J, Wang Z, Yan L, Zhang C, Xu X   +5 more
doaj  

Interpretation of Key Updates in the 36th Edition of Clinical and Laboratory Standards Institute M100 Standard

iLABMED, Volume 4, Issue 3, Page 133-138, September 2026.
ABSTRACT The Clinical and Laboratory Standards Institute M100 document serves as a cornerstone standard for clinical microbiology laboratories in China. Maintaining the scientific rigor of its predecessors, the 36th edition incorporates updated epidemiological cutoff values, pharmacokinetic/pharmacodynamic data, and clinical efficacy evidence to revise
Kanghong Xu, Qi Wang, Hui Wang
wiley   +1 more source

Estudo de isolados clínicos de Pseudomonas aeruginosa multirresistentes e produtores de metalo-ß-lactamases [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2011Nas últimas duas décadas, índices crescentes de resistência têm minado a eficácia
Guarneri, Rômulo
core  

Potential involvement of beta-lactamase homologous proteins in resistance to beta-lactam antibiotics in gram-negative bacteria of the ESKAPEE group

BMC Genomics
Background Enzymatic degradation mediated by beta-lactamases constitutes one of the primary mechanisms of resistance to beta-lactam antibiotics in gram-negative bacteria.
Joyce de Souza, Alexandre Zanatta Vieira, Hellen Geremias dos Santos, Helisson Faoro   +3 more
doaj   +1 more source

«Checkerboard Array» as a Test for Evaluation of Decrease in Gram-Negative Bacteria Resistance to Carbapenems in the Presence of Bisphosphonate [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2015
One of the main mechanisms of resistance of Gramnegative microorganisms to antibiotics is enzymatic hydrolysis by beta-lactamases (for example, metallobeta-lactamases).
Afinogenova A.G., Voroshilova T.M., Afinogenov G.E., Rodionov G.G.   +3 more
doaj  

Interaction of cefotetan and the metallo-beta-lactamases produced in Aeromonas spp. and in vitro activity

, 2000
Aeromonas spp. are increasingly being recognized as human pathogens. The presence of metallo-beta-lactamases in these organisms represents a potential problem in antimicrobial therapy.
Franceschini N., Bonfiglio G., Quiroga M. I., Franchino L., Gutkind G., Amicosante G., Rossolini G. M.   +6 more
core   +1 more source

Identification of extended spectrum beta lactamases, AmpC and carbapenemase production among isolates of Escherichia coli in North Indian tertiary care centre

Avicenna Journal of Medicine, 2018
Introduction: Identification of Extended spectrum beta lactamases (ESBL), AmpC production and carbapenemase production among isolates of Escherichia coli, helps clinician to rationalize the choice of antibiotics.
Uma Chaudhary, Shipra Agarwal, Kausalya Raghuraman   +2 more
doaj   +1 more source