Results 61 to 70 of about 811,638 (168)

Investigating enzyme function by geometric matching of catalytic motifs

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The rapidly growing universe of predicted protein structures offers opportunities for data driven exploration but requires computationally scalable and interpretable tools. We developed a method to detect catalytic features in protein structures, providing insights into enzyme function and mechanism.
Raymund E. Hackett, Ioannis G. Riziotis, Martin Larralde, António J. M. Ribeiro, Georg Zeller, Janet M. Thornton   +5 more
wiley   +1 more source

Metagenomics Reveals Microbial Community Shifts Associated With Contrasting Anthropogenic Impacts in Freshwater Sources of A Coastal Protected Area in Southeastern Brazil

Water Environment Research, Volume 98, Issue 9, September 2026.
Metagenomics revealed distinct anthropogenic signatures in the microbiome of freshwater sources on Marambaia Island, supported by the Anthropogenic Impact Index (AII). Impacted sites showed lower microbial diversity, enrichment of fecal‐associated taxa, and 14 antimicrobial resistance genes, whereas conductivity, salinity, and turbidity explained 88.1%
Bruna Barbosa de Paula, Marize Pereira Miagostovich, Camille Ferreira Mannarino, André Vinicius Costa Ribeiro, Natália Maria Lanzarini, Carla Santos de Oliveira, Shênia Patrícia Corrêa Novo   +6 more
wiley   +1 more source

Sensitivity of Aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases.

, 1997
peer reviewedCeftriaxone and ceftriaxone S-oxide behaved as inactivators against the metallo-beta-lactamase of Aeromonas hydrophila AE036 and as substrates for the zinc beta-lactamase produced by Bacillus cereus (569/H/9) and Stenotrophomonas maltophilia
Oratore, A., Amicosante, G., Franceschini, N., Rossolini, G. M., Galleni, Moreno, Frère, Jean-Marie, Perilli, M., Felici, A., Oratore A., Amicosante G., Perilli M., Frere J. M., Franceschini N., Felici A., Rossolini G. M., Galleni M.   +15 more
core   +2 more sources

A Four‐Center Study on the Activity of Aztreonam and Aztreonam‐Avibactam Combination Against Clinical Isolates of Gram‐Negative Bacilli Producing Representatives of Ambler Class A, B, C or D β‐Lactamases

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT We aimed to investigate the activity of aztreonam and aztreonam‐avibactam combination against gram‐negative bacilli producing different types of β‐lactamases. Activity of aztreonam and aztreonam‐avibactam against 166 isolates (33 AmpC‐producing, 33 ESBL‐producing, 66 carbapenemase‐producing Enterobacterales, 34 metallo‐β‐lactamase‐producing P.
Gizem İnce Ceviz, Hasan Cenk Mirza, Aylin Üsküdar Güçlü, Özlem Öğüç Şanlı, Özlem Kurt Azap, Banu Sancak, Elvan Hortaç İştar, Ahmet Başustaoğlu   +7 more
wiley   +1 more source

Restoring Meropenem Activity Against VIM‐1‐Producing Klebsiella pneumoniae Through Zinc‐Binding Ligands

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Approved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Chiara Ragusa, Ruqaiya Khalil, Valentina Giglio, Kaveh Eskandari, Fraser J. Scott, Attilio V. Vargiu, Graziella Vecchio   +6 more
wiley   +1 more source

Plasmid Profiling and Occurrence of β-Lactamase Enzymes in Multidrug-Resistant Uropathogenic Escherichia coli in Kathmandu, Nepal

Infection and Drug Resistance, 2020
Upendra Thapa Shrestha,1,2,* Sabnum Shrestha,1,* Nabaraj Adhikari,1,2 Komal Raj Rijal,2 Basudha Shrestha,3 Bipin Adhikari,4 Megha Raj Banjara,2 Prakash Ghimire2 1Kantipur College of Medical Science, Tribhuvan University, Sitapaila, Kathmandu, Nepal ...
Thapa Shrestha U, Shrestha S, Adhikari N, Rijal KR, Shrestha B, Adhikari B, Banjara MR, Ghimire P   +7 more
doaj  

A study on detection of extended-spectrum beta-lactamases (ESBLs) and comparison of various phenotypic methods of AmpC detection in Pseudomonas aeruginosa from various clinical isolates in a tertiary care teaching hospital

Muller Journal of Medical Sciences and Research, 2016
Introduction: Pseudomonas aeruginosa is one of the major etiological agents of nosocomial infection. They are difficult to treat as the majority of them exhibit varying degrees of innate resistance.
Subbalakshmi Easwaran, Ranjani Chittur Yerat, Rajendran Ramaswamy   +2 more
doaj   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari, Sepideh Elyasi, Farshad Abedi   +2 more
wiley   +1 more source

Detection of OXA‐23 Among Carbapenem‐Resistant Acinetobacter baumannii Isolated From Intensive Care Units of a Tertiary Care Hospital in Pakistan

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Graphical Abstract of the Experimental Workflow for CRAB Isolate Characterization. ABSTRACT Carbapenem‐resistant Acinetobacter baumannii (CRAB) has been designated a top‐priority critical pathogen by the World Health Organization, and the CDC has also classified it as a serious and immediate public health threat. The Cross‐sectional study was conducted
Hafsa Waseem, Ihsan Ullah, Shahzad Ahmad, Irfan Ali Mirza, Benish Aleem, Shazia Iqbal   +5 more
wiley   +1 more source

Approaches to the simultaneous inactivation of metallo- and serine-beta-lactamases

, 2009
A series of cephalosporin-derived reverse hydroxamates and oximes were prepared and evaluated as inhibitors of representative metallo- and serine-beta-lactamases.
Ganta, SR, Perumal, S, Pratt, RF, Spencer, J, Pagadala, SR, Samuelsen, O, Buynak, JD   +6 more
core   +1 more source