Results 91 to 100 of about 6,440 (201)

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Purification, characterization, and structural elucidation of serralysin-like alkaline metalloprotease from a novel source

Journal of Genetic Engineering and Biotechnology, 2019
Background Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications.
Swathi Nageswara, Girijasankar Guntuku, Bhagya Lakshmi Yakkali   +2 more
doaj   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, Volume 98, Issue 1, Page 67-79, July 2025.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

The Novel Chloroplast Outer Membrane Kinase KOC1 Is a Required Component of the Plastid Protein Import Machinery [PDF]

, 2017
The biogenesis and maintenance of cell organelles such as mitochondria and chloroplasts require the import of many proteins from the cytosol, a process that is controlled by phosphorylation.
Agne, Birgit, Baginsky, Sacha, Demarsy, Emilie, Douet, Véronique, Kessler, Felix, Montandon, Cyrille, Zufferey, Mónica   +6 more
core   +2 more sources

Tectorigenin Ameliorates Glucocorticoid‐Induced Osteoporosis by Inhibiting the NF‐κB Signal Pathway and Modulating Treg‐Th17 Cell Balance

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT Glucocorticoid‐induced osteoporosis is a common clinical orthopaedic disease, primarily due to excessive use of hormones. Tectorigenin has shown a certain efficacy in treating osteoporosis, but its underlying mechanisms are not yet fully understood.
Peng Peng, Puiian Wong, Zheng Lv, Jiaqing Tian, Wei He, Qiushi Wei, Hui Mo, Mincong He   +7 more
wiley   +1 more source

Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases [PDF]

, 1997
Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp) and Abz-DArg-Arg-Phe ...
Boileau, G., Carvalho, K.m., França, M.s.f., Juliano, Luiz, Medeiros, M.a.s.   +4 more
core   +4 more sources

Chromosomal and Genetic Analysis of a Human Lung Adenocarcinoma Cell Line OM

Chinese Medical Journal, 2016
Background: Lung cancer has become the leading cause of death in many regions. Carcinogenesis is caused by the stepwise accumulation of genetic and chromosomal changes.
Yong-Wu Li, Lin Bai, Lyu-Xia Dai, Xu He, Xian-Ping Zhou   +4 more
doaj   +1 more source

Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes [PDF]

, 2010
The exoskeleton or cuticle performs many key roles in the development and survival of all nematodes. This structure is predominantly collagenous in nature and requires numerous enzymes to properly fold, modify, process and cross-link these essential ...
Albertson, Antony P. Page, Bastin, Bird, Blaxter, Blelloch, Davis, Gallego, Gamble, Gamble, Ge, Gillian McCormack, Gillian Stepek, Hartigan, Hawdon, Hill, Hishida, Jones, Keskiaho, Kessler, Mitreva, Moerman, Möhrlen, Nelson, Novelli, Novelli, Opperman, Page, Redmond, Shamansky, Stepek, Studier, Stöcker, Stöcker, Suzuki, Thein, Van der Keyl, Williamson   +37 more
core   +1 more source

Generation of active fragments from human zymogens in the bradykinin-generating cascade by extracellular proteases from Vibrio vulnificus and V. parahaemolyticus [PDF]

, 2004
Vibrio vulnificus is an opportunistic human pathogen causing septicemia, and the infection is characterized by formation of the edematous skin lesions on limbs.
Carvalho, Hooper, Hovinga, Imamura, Ishihara, Janda, Kaminishi, Kim, Lee, Maruo, Miyoshi, Miyoshi, Miyoshi, Miyoshi, Miyoshi, Miyoshi, Molla, Morihara, Park, Semba, Shibuya, Sottrup-Jensen, Tanaka, Watanabe, Wolz, Zevaco   +25 more
core   +1 more source

The use of Fluorescence Resonance Energy Transfer (FRET) peptidesfor measurement of clinically important proteolytic enzymes [PDF]

, 2009
Proteolytic enzymes have a fundamental role in many biological processes and are associated with multiple pathological conditions. Therefore, targeting these enzymes may be important for a better understanding of their function and development of ...
Carmona, Adriana Karaoglanovic, Juliano, Luiz, Juliano, Maria Aparecida   +2 more
core   +3 more sources