Results 81 to 90 of about 4,754 (192)

Chromosomal and Genetic Analysis of a Human Lung Adenocarcinoma Cell Line OM

Chinese Medical Journal, 2016
Background: Lung cancer has become the leading cause of death in many regions. Carcinogenesis is caused by the stepwise accumulation of genetic and chromosomal changes.
Yong-Wu Li, Lin Bai, Lyu-Xia Dai, Xu He, Xian-Ping Zhou   +4 more
doaj   +1 more source

Purification, characterization, and structural elucidation of serralysin-like alkaline metalloprotease from a novel source

Journal of Genetic Engineering and Biotechnology, 2019
Background Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications.
Swathi Nageswara, Girijasankar Guntuku, Bhagya Lakshmi Yakkali   +2 more
doaj   +1 more source

The Enterococcus faecalis Extracellular Metalloendopeptidase (EC 3.4.24.30; Coccolysin) Inactivates Human Endothelin at Bonds Involving Hydrophobic Amino Acid Residues

, 1994
The extracellular metalloendopeptidase (EC 3.4.24.30; coccolysin) from Enterococcus faecalis (Strain OG1-10) inactivates human endothelin-1 by hydrolyzing the peptide primarily at the Ser5-Leu6 and the His16-Leu17 bonds and the human big endothelin at ...
Makinen P. L., Makinen K. K.
core   +1 more source

Kinin B2 Receptor-Mediated Bradykinin Internalization and Metalloendopeptidase EP24.15-Dependent Intracellular Bradykinin Degradation

, 2008
Kinins are potent proinflammatory peptides that are produced extracellularly and rapidly degraded by extracellular peptidases and by intracellular peptidases accessed by kinins via receptor-mediated endocytosis.
Bengtson, Sara,, Sandén, Caroline,, Leeb-Lundberg, Fredrik,, Lund University., Herwald, Heiko,, Enquist, Johan,   +5 more
core   +2 more sources

The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors

, 2009
Pitrm1 is a zinc metalloendopeptidase that has been implicated in Alzheimer's disease and mitochondrial peptide degradation, but to date no major role in embryonic development has been documented.
Butterfield, Natalie C., Metzis, Vicki, Fiorenza, Salvatore, McGlinn, Edwina, Town, Liam, Wicking, Carol, Richman, Joy M.   +6 more
core   +1 more source

Variants in MME are associated with autosomal‐recessive distal hereditary motor neuropathy

Annals of Clinical and Translational Neurology, 2019
Objective To identify a new genetic cause in patients segregating distal hereditary motor neuropathy (dHMN) with an autosomal recessive pattern. Methods Whole‐exome sequencing was conducted in two siblings and was combined with segregation analysis ...
Daojun Hong, Pu Fang, Sheng Yao, Juanjuan Chen, Xiaolei Zhang, Shuyun Chen, Jingfen Zhang, Dandan Tan, Li Wang, Xinsheng Han, Ling Xin, Yan Wang, Meige Liu, Lu Cong, Shanshan Zhong, Hui Ouyang, Xuguang Gao, Jun Zhang   +17 more
doaj   +1 more source

Primary Structure ofStreptomyces griseusMetalloendopeptidase II

Bioscience, Biotechnology, and Biochemistry, 1998
Streptomyces griseus metalloendopeptidase II (SGMPII) is a unique protease, since it shows anomalous susceptibility to the proteinaceous "serine protease inhibitors" produced by Streptomyces, such as Streptomyces subtilisin inhibitor (SSI) and its homologous proteins.
KOJIMA, Shuichi, KUMAZAKI, Takashi, ISHII, Shin-ichi, MIURA, Kin-ichiro   +3 more
openaire   +2 more sources

Evaluation of Metalloendopeptidase Lys-N Protease Performance under Different Sample Handling Conditions

, 2016
Trypsin, the most widely used enzyme in proteomics, has a few caveats as it does not perform well under certain harsh sample handling conditions and creates relatively short peptides less amenable to, for instance, electron transfer dissociation.
Shabaz Mohammed (237215), Albert J. R. Heck (9680), Nadia Taouatas (237192)   +2 more
core   +1 more source

CCK26-33 degrading activity in brain and nonneural tissue: a metalloendopeptidase.

, 1985
Cholecystokinin octapeptide (CCK26-33) is metabolized by neural membranes with an initial cleavage to CCK29-33 and subsequent breakdown to CCK31-33 and CCK32-33; this pattern of proteolysis occurs on incubation with either P2 or purified lysed ...
Kask AM, BARONE, Paolo, Knight M, Steardo L, CHASE TN, STEARDO, LUCA, Chase T.N., BARONE P, Tamminga CA   +8 more
core   +1 more source

Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia.

, 2003
We tested the hypothesis that metalloendopeptidase inhibition using phosphoramidon during induction of endotoxemia 24 h later would down-regulate the protein expression of myocardial inducible nitric oxide synthase (iNOS) and phosphorylation of p38 ...
Sharma, Avadhesh C., Gupta, A.
core   +1 more source