Results 61 to 70 of about 4,088 (165)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, Volume 20, Issue 2, Page 331-347, February 2026.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, Volume 13, Issue 12, 27 February 2026.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer

Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways.
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya’an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H. Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E. I. Mustapha Bahassi, Peter J. Stambrook, Peng Huang, Jason B. Fleming, Anirban Maitra, John A. Tainer, Mien-Chie Hung, Chunru Lin, Paul J. Chiao   +30 more
doaj   +1 more source

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits

Aging Cell, Volume 25, Issue 2, February 2026.
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen, Jennifer L. Martindale, Martina Rossi, Chang Hoon Shin, Apala Pal, Rachel Munk, Martin Salamini‐Montemurri, Mirko Baranzini, Ethan M. Arends, Maja Mustapic, Yuta Lee, Jau‐Nan Lee, Sicco H. Popma, Justin Hu, Nathan Duda, Carlos J. Nogueras‐Ortiz, Dimitrios Kapogiannis, Chang‐Yi Cui, Myriam Gorospe   +18 more
wiley   +1 more source

Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma

Dental Research Journal, 2016
Background: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more ...
Elham Hormozi, Vahid Nourollahi Fard, Mohammad Ali Naseri, Nima Haghighat Jahromi, Forooz Keshani   +4 more
doaj   +1 more source

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

Aging Cell, Volume 25, Issue 2, February 2026.
Young multipotent muscle‐derived stem/progenitor cells (MDSPCs) secrete a unique profile of pro‐angiogenic and immunomodulatory proteins that are diminished with age. Systemic transplantation of young MDSPCs into naturally aged mice activates pathways in neuromuscular tissues, enhancing health and driving molecular, structural, and functional ...
Seth D. Thompson, Chelsea L. Rugel, Maddlyn R. Haller, Jodi L. Curtin, Sudarshan Dayanidhi, Mitra Lavasani   +5 more
wiley   +1 more source

Purification, characterization, and structural elucidation of serralysin-like alkaline metalloprotease from a novel source

Journal of Genetic Engineering and Biotechnology, 2019
Background Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications.
Swathi Nageswara, Girijasankar Guntuku, Bhagya Lakshmi Yakkali   +2 more
doaj   +1 more source

Chromosomal and Genetic Analysis of a Human Lung Adenocarcinoma Cell Line OM

Chinese Medical Journal, 2016
Background: Lung cancer has become the leading cause of death in many regions. Carcinogenesis is caused by the stepwise accumulation of genetic and chromosomal changes.
Yong-Wu Li, Lin Bai, Lyu-Xia Dai, Xu He, Xian-Ping Zhou   +4 more
doaj   +1 more source

Variants in MME are associated with autosomal‐recessive distal hereditary motor neuropathy

Annals of Clinical and Translational Neurology, 2019
Objective To identify a new genetic cause in patients segregating distal hereditary motor neuropathy (dHMN) with an autosomal recessive pattern. Methods Whole‐exome sequencing was conducted in two siblings and was combined with segregation analysis ...
Daojun Hong, Pu Fang, Sheng Yao, Juanjuan Chen, Xiaolei Zhang, Shuyun Chen, Jingfen Zhang, Dandan Tan, Li Wang, Xinsheng Han, Ling Xin, Yan Wang, Meige Liu, Lu Cong, Shanshan Zhong, Hui Ouyang, Xuguang Gao, Jun Zhang   +17 more
doaj   +1 more source

Primary Structure ofStreptomyces griseusMetalloendopeptidase II

Bioscience, Biotechnology, and Biochemistry, 1998
Streptomyces griseus metalloendopeptidase II (SGMPII) is a unique protease, since it shows anomalous susceptibility to the proteinaceous "serine protease inhibitors" produced by Streptomyces, such as Streptomyces subtilisin inhibitor (SSI) and its homologous proteins.
KOJIMA, Shuichi, KUMAZAKI, Takashi, ISHII, Shin-ichi, MIURA, Kin-ichiro   +3 more
openaire   +2 more sources