Results 71 to 80 of about 4,754 (192)

Associations of Neprilysin and Its Coding Gene Variation With Hypertension in Chinese Adults

The Journal of Clinical Hypertension, Volume 28, Issue 4, April 2026.
ABSTRACT Neprilysin (NEP) degrades several vasoactive peptides and may contribute to blood pressure maintenance. This study aims to examine the associations between serum NEP levels and variants at its coding gene and hypertension in a general Chinese population.
Junting Hu, Jing Duan, Jiexiang Jing, Qiu Zhang, Xianfeng Yu, Rongyan Zhang, Yuting Jia, Mingzhe Du, Penghao Wang, Xueyang Zhang, Yibing Jin, Xiangdong Yang, Mingzhi Zhang, Hao Peng, Yun Shen   +14 more
wiley   +1 more source

Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer

Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways.
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya’an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H. Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E. I. Mustapha Bahassi, Peter J. Stambrook, Peng Huang, Jason B. Fleming, Anirban Maitra, John A. Tainer, Mien-Chie Hung, Chunru Lin, Paul J. Chiao   +30 more
doaj   +1 more source

The Genetic Basis of Color Polymorphism in the Orb‐Web Spider Gasteracantha cancriformis

Ecology and Evolution, Volume 16, Issue 3, March 2026.
This study investigates the genetic basis of coloration in the polymorphic spider Gasteracantha cancriformis using RNA‐seq data from different female color morphs. We assembled a reference transcriptome and identified differentially expressed genes associated with known pigmentation pathways, including carotenoids, melanin, ommochromes, and pteridines.
Paula Torres‐Quintero, Carolina Pardo‐Díaz, Fabian Salgado‐Roa, Camilo Salazar   +3 more
wiley   +1 more source

Cattle tick Boophilus microplus salivary gland contains a thiol-activated metalloendopeptidase displaying kininase activity

, 2002
This work reports on the characterization of a metalloendopeptidase kininase present in Boophilus microplus salivary glands. Using the guinea pig ileum assay, salivary gland whole extracts (SGE) were found to have a potent kininase activity. Ion-exchange
Hillebrand S., Kist T.B.L., Termignoni C., Horn F., Bastiani M., Guimaraes J.A.   +5 more
core   +1 more source

Honokiol and Magnolol Exert an Anti‐Inflammatory Effect by Inhibiting JAK2/STAT3/IL17 Signalling in a Rat Model of Ulcerative Colitis: A Combination of Bioinformatics and Experimental Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Ulcerative colitis (UC) is a chronic, inflammatory bowel disease with limited clinical treatment. Traditional Chinese medicinal ingredients honokiol and magnolol have potential anti‐inflammatory and gastrointestinal protective effects. However, their anti‐inflammatory potential has not been investigated in UC.
Zhaoxu Cai, Shaojun Lu, Jingan Chen, Xiaoshan Yang, Junlin Lu, Changwen Feng   +5 more
wiley   +1 more source

Straightforward and de novo peptide sequencing by MALDI-MS/MS using a Lys-N metalloendopeptidase.

, 2008
In this work, we explore the potential of the metalloendopeptidase Lys-N for MALDI-MS/MS proteomics applications. Initially we digested a HEK293 cellular lysate with Lys-N and, for comparison, in parallel with the protease Lys-C.
Altelaar, AF, Mohammed, Shabaz, Shabaz Mohammed, Taouatas, N., Mohammed, S., Joost W. Gouw, Pappin, D. J., Pappin, DJ, Boersema, P. J., Mohammed, S, Paul J. Boersema, Gouw, JW, Philip L. Ross, Ross, P. L., Taouatas, N, Heck, AJ, Darryl J. Pappin, Ross, PL, Heck, A. J. R., Albert J. R. Heck, Nadia Taouatas, Gouw, J. W., A. F. Maarten Altelaar, Boersema, PJ, Altelaar, A. F. M.   +24 more
core   +1 more source

Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma

Dental Research Journal, 2016
Background: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more ...
Elham Hormozi, Vahid Nourollahi Fard, Mohammad Ali Naseri, Nima Haghighat Jahromi, Forooz Keshani   +4 more
doaj   +1 more source

Röntgenkristallographische Analyse zur Bestimmung von Struktur-Funktionsbeziehungen zur toxischen Metalloendopeptidase AsaP1 sowie zur Haloalkan Dehalogenase DppA [PDF]

, 2012
Metalloendopeptidase AsaP1 Die extrazelluläre Metalloendopeptidase AsaP1 wird als Zymogen exprimiert. Sie ist hoch immunogen und hauptsächlicher Virulenzfaktor von einigen atypischen Aeromonas salmonicida Stämmen, die als Krankheitserreger bei einer ...
Bogdanovic, Xenia
core   +1 more source

A novel, robust peptidyl-lys metalloendopeptidase from Trametes coccinea recombinantly expressed in Komagataella phaffii. [PDF]

Appl Microbiol Biotechnol
A novel peptidyl-lys metalloendopeptidase (Tc-LysN) from Tramates coccinea was recombinantly expressed in Komagataella phaffii using the native pro-protein sequence. The peptidase was secreted into the culture broth as zymogen (~38 kDa) and mature enzyme
Ahmed U, Stadelmann T, Heid D, Würtz B, Pfannstiel J, Ochsenreither K, Eisele T.   +6 more
europepmc   +2 more sources

Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRα(+) Cells Is a New Marker for Inflammatory Bowel Disease

, 2022
Metalloendopeptidase ADAM-Like Decysin 1 (ADAMDEC1) is an anti-inflammatory peptidase that is almost exclusively expressed in the gastrointestinal (GI) tract. We have recently found abundant and selective expression of Adamdec1 in colonic mucosal PDGFRα(+
Kim, Yong-Sung, Lee, Moon-Young, Sandra M. Poudrier, Kenton M. Sanders, Min-Seob Kim, Moon-Young Lee, Sasse, Kent C., Ro, Seungil, Jorgensen, Brian G., Laren Becker, Sei Kim, Allison Bartlett, Jin, Byungchang, Gottfried-Blackmore, Andres, Andres Gottfried-Blackmore, Kim, Sei, Byungchang Jin, Suck-Chei Choi, Habtezion, Aida, Kent C. Sasse, Seungil Ro, Masaaki Kurahashi, Wei, Lai, Samuel J. S. Rubin, Hannah Zogg, Rubin, Samuel J. S., Se Eun Ha, Rajan Singh, Bartlett, Allison, Becker, Laren, Sanders, Kenton M., Singh, Rajan, Ha, Se Eun, Kim, Min-Seob, Baek, Gain, Poudrier, Sandra M., Brian G. Jorgensen, Gain Baek, Lai Wei, Kurahashi, Masaaki, Choi, Suck-Chei, Aida Habtezion, Zogg, Hannah, Yong-Sung Kim   +43 more
core   +1 more source