Results 51 to 60 of about 4,754 (192)

Salvianolic Acid B Inhibits Ferroptosis in Acute Lung Injury: Network Analysis and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT This current study aimed to decipher the anti‐inflammatory, anti‐ferroptosis and pronounced lung‐protective activities of Salvianolic acid B (Sal B) by integrating network pharmacology and experimental confirmation across multiple aspects. The optimal target protein and the relevant molecular mechanisms for Sal B in the context of ALI were ...
Hejun Gao, Renhui Xiong, Na Yue, Jiaxin Wang, Shouyuan Tian   +4 more
wiley   +1 more source

A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis. [PDF]

, 2010
Several single-nucleotide polymorphism (SNP) genome-wide association studies (GWASs) have been completed in multiple sclerosis (MS). Follow-up studies of the variants with the most promising rankings, especially when supplemented by informed candidate ...
A J Ivinson, J Lechner-Scott, J Haines, Ivinson, A. J., Wason, James, Hafler, D. A., Compston, Alastair, Lechner-Scott, Jeannette, S L Hauser, Wason, J., Sexton, David, Bergamaschi, Laura, Sexton, D., Hauser, SL, Zuvich, Rebecca, Dudbridge, Frank, De Jager, Philip L, D'Alfonso, S, D’Alfonso, Sandra, Pericak-Vance, Margaret A, Robertson, NP, Barcellos, L. F., Guerini, Franca R, Wason, J, Ban, M, Sawcer, S, Dudbridge, F., A Baker, D Sexton, Zuvich, R, McCauley, Jacob L, F Dudbridge, S Sawcer, Barcellos, LF, F R Guerini, Baker, A, Sawcer, S., Ban, Maria, J Wason, Kemppinen, A., Lechner-Scott, J., Hauser, Stephen L, J R Oksenberg, Pericak-Vance, M. A., Compston, A, Sawcer, Stephen, Pericak-Vance, MA, Cox, M., L Bergamaschi, D A Hafler, N P Robertson, Oksenberg, J. R., Robertson, Neil, Hafler, David A, Cox, M, De Jager, PL, A Kemppinen, S D'Alfonso, Bergamaschi, L., Kemppinen, A, Hauser, S. L., Oksenberg, JR, Oksenberg, Jorge R, Guerini, FR, L F Barcellos, Haines, Jonathan, Zuvich, R., D'Alfonso, S., Sexton, D, M Ban, Lechner-Scott, J, Haines, J, Compston, A., M Cox, J L McCauley, McCauley, JL, Hafler, DA, M A Pericak-Vance, Ivinson, AJ, Robertson, Neil P, R Zuvich, Kemppinen, Anu, Bergamaschi, L, Guerini, F. R., Haines, J., Ban, M., McCauley, J. L., Cox, Mathew, Baker, Amie, P L De Jager, De Jager, P. L., A Compston, Ivinson, Adrian J, Barcellos, Lisa F, Dudbridge, F, Baker, A.   +95 more
core   +1 more source

Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Toxins, 2016
The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom.
Viviane A. Bastos, Francisco Gomes-Neto, Jonas Perales, Ana Gisele C. Neves-Ferreira, Richard H. Valente   +4 more
doaj   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Characterization of the Pseudomonas aeruginosa metalloendopeptidase, Mep72, a member of the Vfr regulon [PDF]

, 2013
cc-byBackground: Pseudomonas aeruginosa Vfr (the virulence factor regulator) enhances P. aeruginosa virulence by positively regulating the expression of numerous virulence genes.
Hamood, Abdul N., Colmer-Hamood, Jane A., Balyimez, Aysegul, San Francisco, Michael   +3 more
core   +1 more source

Insulin-Degrading Enzyme Regulates the Proliferation and Apoptosis of Porcine Skeletal Muscle Stem Cells via Myostatin/MYOD Pathway

Frontiers in Cell and Developmental Biology, 2021
Identifying the genes relevant for muscle development is pivotal to improve meat production and quality in pigs. Insulin-degrading enzyme (IDE), a thiol zinc-metalloendopeptidase, has been known to regulate the myogenic process of mouse and rat myoblast ...
Bingyuan Wang, Jiankang Guo, Mingrui Zhang, Mingrui Zhang, Zhiguo Liu, Rong Zhou, Fei Guo, Kui Li, Kui Li, Yulian Mu   +9 more
doaj   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice

Nature Communications
Microglia play crucial roles in Alzheimer’s disease (AD), yet the molecular mechanisms are unclear. Here, we show that CD31, a recognized endothelial marker, is predominantly expressed in microglia but not in neurons or astrocytes, and it is ...
Qiuzhi Zhou, Fei Sun, Yao Zhang, Xiaojian Cao, Mengzhu Li, Haitao Yu, Tao Jiang, Shihong Li, Weixia Wang, Jiazhao Xie, Ting He, Yanchao Liu, Dan Ke, Xiao-Chuan Wang, Peng Xu, Enjie Liu, Hong Chen, Jian-Zhi Wang   +17 more
doaj   +1 more source

Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration

WIREs Mechanisms of Disease, Volume 18, Issue 4, July/August 2026.
Quality control pathways form an integrated proteostasis–mitochondrial quality control axis that maintains mitochondrial and cellular homeostasis. Failure of this coordinated network drives neuronal decline and contributes to neurodegeneration. ABSTRACT Quality control (QC) processes include a network of cellular pathways that prevent the accumulation ...
Rosa Di Lorenzo, Rola S. Zeidan, Riccardo Calvani, Vito Pesce, Emanuele Marzetti, Anna Picca   +5 more
wiley   +1 more source

Features of gene expression of Bacillus pumilus metalloendopeptidase

, 2020
© 2016, Pleiades Publishing, Ltd.Features of gene expression of the secreted Bacillus pumilus metalloendopeptidase belonging to the adamalysin/reprolysin family were investigated.
Sabirova A., Tikhonova A., Balaban N., Sharipova M., Rudakova N.   +4 more
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