Results 31 to 40 of about 4,088 (165)

The stromal processing peptidase of chloroplasts is essential in Arabidopsis, with knockout mutations causing embryo arrest after the 16-cell stage. [PDF]

PLoS ONE, 2011
Stromal processing peptidase (SPP) is a metalloendopeptidase located in the stroma of chloroplasts, and it is responsible for the cleavage of transit peptides from preproteins upon their import into the organelle. Two independent mutant Arabidopsis lines
Raphael Trösch, Paul Jarvis
doaj   +1 more source

Role of CD10 as a Prognostic Marker in Invasive Breast Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Stromal markers have been proved as important markers in assessing the prognosis of invasive breast cancer. Cluster of Differentiation (CD)10 is a cell surface enzyme with metalloendopeptidase activity which is expressed in stroma of ...
Subitha Kandamuthan, Renu Thambi
doaj   +1 more source

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

The Journal of Clinical Investigation, 2022
Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood.
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K.E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, Derek P. Narendra   +16 more
doaj   +1 more source

A nonsense mutation in MME gene associates with autosomal recessive late‐onset Charcot–Marie–Tooth disease

Molecular Genetics & Genomic Medicine, 2022
Background The genetic cause for the majority of patients with late‐onset axonal form of neuropathies have remained unknown. In this study we aimed to identify the causal mutation in a family with multiple affected individuals manifesting a range of ...
Zeinab Jamiri, Rana Khosravi, Mohammad Mehdi Heidari, Ebrahim Kiani, Javad Gharechahi   +4 more
doaj   +1 more source

Markers and antibodies for characterization of goat mammary tissue and the derived primary epithelial cell cultures

Revista Brasileira de Zootecnia, 2020
A selection of commercially available antibodies, targeted against markers employed in studies of mammary gland biology, was tested to determine their reactivity in goat mammary tissue and the derived tissue cultures.
Sonja Prpar Mihevc, Jernej Ogorevc, Peter Dovč   +2 more
doaj   +1 more source

Homologues of insulinase, a new superfamily of metalloendopeptidases [PDF]

Biochemical Journal, 1991
On the basis of a statistical analysis of an alignment of the amino acid sequences, a new superfamily of metalloendopeptidases is proposed, consisting of human insulinase, Escherichia coli protease III and mitochondrial processing endopeptidases from Saccharomyces and Neurospora.
N D, Rawlings, A J, Barrett
openaire   +2 more sources

A new brain metalloendopeptidase which degrades the Alzheimer ß-amyloid 1-40 peptide producing soluble fragments without neurotoxic effects

Brazilian Journal of Medical and Biological Research, 1997
A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human brain using successive steps of chromatography on DEAE-Trisacryl, hydroxylapatite and Sephacryl S-200.
K.M. Carvalho, M.S.F. França, G.C. Camarão, A.F. Ruchon   +3 more
doaj   +1 more source

The astacin family of metalloendopeptidases.

Journal of Biological Chemistry, 1991
Molecular cloning of a human intestinal brush border metalloendopeptidase (N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PPH) and a mouse kidney brush border metalloendopeptidase (meprin A) has revealed 82% identity in the NH2-terminal amino acid sequences (198 residues) of the mature enzymes.
E, Dumermuth, E E, Sterchi, W P, Jiang, R L, Wolz, J S, Bond, A V, Flannery, R J, Beynon   +6 more
openaire   +2 more sources

Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display. [PDF]

PLoS ONE, 2018
Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing.
Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissring   +7 more
doaj   +1 more source

Analysis of G-quadruplex forming sequences in podocytes-marker genes and their potential roles in inherited glomerular diseases

Heliyon, 2023
Nephrotic Syndrome is the most widespread pediatric kidney disorder. Genetic alterations in podocyte genes are thought to be responsible for the disease. G-quadruplexes are non-conventional guanine-rich DNA and RNA structures, which are commonly found in
Mona Saad, Cybel Mehawej, Wissam H. Faour   +2 more
doaj   +1 more source