Results 31 to 40 of about 4,754 (192)

Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia

Scientific Reports, 2021
This study aimed to determine possible association of eight polymorphisms of seven MMP genes with essential hypertension (EH) in a Caucasian population of Central Russia.
Maria Moskalenko, Irina Ponomarenko, Evgeny Reshetnikov, Volodymyr Dvornyk, Mikhail Churnosov   +4 more
doaj   +1 more source

Role of CD10 as a Prognostic Marker in Invasive Breast Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Stromal markers have been proved as important markers in assessing the prognosis of invasive breast cancer. Cluster of Differentiation (CD)10 is a cell surface enzyme with metalloendopeptidase activity which is expressed in stroma of ...
Subitha Kandamuthan, Renu Thambi
doaj   +1 more source

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

The Journal of Clinical Investigation, 2022
Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood.
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K.E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, Derek P. Narendra   +16 more
doaj   +1 more source

Markers and antibodies for characterization of goat mammary tissue and the derived primary epithelial cell cultures

Revista Brasileira de Zootecnia, 2020
A selection of commercially available antibodies, targeted against markers employed in studies of mammary gland biology, was tested to determine their reactivity in goat mammary tissue and the derived tissue cultures.
Sonja Prpar Mihevc, Jernej Ogorevc, Peter Dovč   +2 more
doaj   +1 more source

A nonsense mutation in MME gene associates with autosomal recessive late‐onset Charcot–Marie–Tooth disease

Molecular Genetics & Genomic Medicine, 2022
Background The genetic cause for the majority of patients with late‐onset axonal form of neuropathies have remained unknown. In this study we aimed to identify the causal mutation in a family with multiple affected individuals manifesting a range of ...
Zeinab Jamiri, Rana Khosravi, Mohammad Mehdi Heidari, Ebrahim Kiani, Javad Gharechahi   +4 more
doaj   +1 more source

Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts

Memorias do Instituto Oswaldo Cruz, 2010
Neuropathy and bone deformities, lifelong sequelae of leprosy that persist after treatment, result in significant impairment to patients and compromise their social rehabilitation.
Sandra R Boiça Silva, Antônio J Tempone, Tatiana P Silva, Maria Renata SN Costa, Geraldo MB Pereira, Flávio A Lara, Maria Cristina V Pessolani, Danuza Esquenazi   +7 more
doaj   +1 more source

metalloendopeptidase using molecular docking analysis

, 2022
Jatropha mollissima is endemic to Brazil and is used for traditional medicinal purposes, including the treatment of snakebite. In this study, latex obtained from this plant was fractioned using reversed-phase chromatography, and the fractions were then ...
Stephen P. Mackessy, Ana Cristina Oliveira Monteiro‐Moreira, Mackessy, Stephen P., Antônio Eufrásio Vieira Neto, Cilli, Eduardo Maffud [UNESP], Neto, Antônio Eufrásio Vieira, Eduardo Maffud Cilli, Thiago Lustosa Jucá, Márcio Viana Ramos, Ramos, Márcio Viana, Jucá, Thiago Lustosa, Monteiro-Moreira, Ana Cristina Oliveira   +11 more
core   +1 more source

A new brain metalloendopeptidase which degrades the Alzheimer ß-amyloid 1-40 peptide producing soluble fragments without neurotoxic effects

Brazilian Journal of Medical and Biological Research, 1997
A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human brain using successive steps of chromatography on DEAE-Trisacryl, hydroxylapatite and Sephacryl S-200.
K.M. Carvalho, M.S.F. França, G.C. Camarão, A.F. Ruchon   +3 more
doaj   +1 more source

The astacin family of metalloendopeptidases.

Journal of Biological Chemistry, 1991
Molecular cloning of a human intestinal brush border metalloendopeptidase (N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PPH) and a mouse kidney brush border metalloendopeptidase (meprin A) has revealed 82% identity in the NH2-terminal amino acid sequences (198 residues) of the mature enzymes.
E, Dumermuth, E E, Sterchi, W P, Jiang, R L, Wolz, J S, Bond, A V, Flannery, R J, Beynon   +6 more
openaire   +2 more sources

Homologues of insulinase, a new superfamily of metalloendopeptidases [PDF]

Biochemical Journal, 1991
On the basis of a statistical analysis of an alignment of the amino acid sequences, a new superfamily of metalloendopeptidases is proposed, consisting of human insulinase, Escherichia coli protease III and mitochondrial processing endopeptidases from Saccharomyces and Neurospora.
N D, Rawlings, A J, Barrett
openaire   +2 more sources