Results 21 to 30 of about 4,088 (165)

Expression and Regulatory Network Analysis of MiR-139-3p, a New Potential Serum Biomarker for Esophageal Squamous Cell Carcinoma Based on Bioinformatics Analysis

Technology in Cancer Research & Treatment, 2020
Background: In recent studies, microRNAs have been demonstrated as stable detectable biomarkers in blood for cancer. In addition, computer-aided biomarker discovery has now become an attractive paradigm for precision diagnosis. Methods: In this study, we
Yonghong Wang MM, Qimei Fang BM, Liru Tian BM, Zhongzhen Yuan MM, Lizhen Tian BM, Zhongli Zhou BM   +5 more
doaj   +1 more source

Soluble Metalloendopeptidases and Neuroendocrine Signaling [PDF]

Endocrine Reviews, 2002
Peptidases play a vital and often highly specific role in the physiological and pathological generation and termination of peptide hormone signals. The thermolysin-like family of metalloendopeptidases involved in the extracellular processing of neuroendocrine and cardiovascular peptides are of particular significance, reflecting both their specificity ...
Corie N, Shrimpton, A Ian, Smith, Rebecca A, Lew   +2 more
openaire   +2 more sources

A Novel Bi-Functional Fibrinolytic Enzyme with Anticoagulant and Thrombolytic Activities from a Marine-Derived Fungus Aspergillus versicolor ZLH-1

Marine Drugs, 2022
Fibrinolytic enzymes are important components in the treatment of thrombosis-associated disorders. A new bi-functional fibrinolytic enzyme, versiase, was identified from a marine-derived fungus Aspergillus versicolor ZLH-1.
Lihong Zhao, Xiuping Lin, Jingyun Fu, Jun Zhang, Wei Tang, Zengguo He   +5 more
doaj   +1 more source

Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells

Cells, 2022
The insulin-degrading enzyme (IDE) is a zinc-dependent metalloendopeptidase that belongs to the M16A metalloprotease family. IDE is markedly expressed in the brain, where it is particularly relevant due to its in vitro amyloid beta (Aβ)-degrading ...
Miriam Corraliza-Gómez, Concepción Lillo, Irene Cózar-Castellano, Eduardo Arranz, Diego Sanchez, Maria D. Ganfornina   +5 more
doaj   +1 more source

Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis. [PDF]

PLoS ONE, 2008
Meprin (EC 3.4.24.18) is an oligomeric metalloendopeptidase found in microvillar membranes of kidney proximal tubular epithelial cells. Here, we present the first report on the expression of meprin beta in rat glomerular epithelial cells and suggest a ...
Beatrice Oneda, Nadège Lods, Daniel Lottaz, Christoph Becker-Pauly, Walter Stöcker, Jeffrey Pippin, Maya Huguenin, Daniel Ambort, Hans-Peter Marti, Erwin E Sterchi   +9 more
doaj   +1 more source

Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia

Scientific Reports, 2021
This study aimed to determine possible association of eight polymorphisms of seven MMP genes with essential hypertension (EH) in a Caucasian population of Central Russia.
Maria Moskalenko, Irina Ponomarenko, Evgeny Reshetnikov, Volodymyr Dvornyk, Mikhail Churnosov   +4 more
doaj   +1 more source

Subtractive genomic analysis for computational identification of putative immunogenic targets against clinical Enterobacter cloacae complex.

PLoS ONE, 2022
BackgroundEnterobacter is a major nosocomial genus of Enterobacteriaceae responsible for a variety of nosocomial infections, particularly in prolonged hospitalized patients in the intensive care units.
Negin Bolourchi, Sepideh Fereshteh, Narjes Noori Goodarzi, Farzad Badmasti   +3 more
doaj   +2 more sources

Extracellular matrix and dermal nerve growth factor dysregulation in prurigo nodularis compared to atopic dermatitis

Frontiers in Medicine, 2022
Prurigo nodularis (PN) is a chronic, pruritic, inflammatory skin disease characterized by hyperkeratotic nodules on the trunk and extremities. While there is growing research on the immunological basis of PN, the neuropathic and structural components of ...
Junwen Deng, Varsha Parthasarathy, Melika Marani, Zachary Bordeaux, Kevin Lee, Chi Trinh, Hannah L. Cornman, Anusha Kambala, Thomas Pritchard, Shihua Chen, Nishadh Sutaria, Olusola O. Oladipo, Madan M. Kwatra, Martin P. Alphonse, Shawn G. Kwatra   +14 more
doaj   +1 more source

Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts

Memorias do Instituto Oswaldo Cruz, 2010
Neuropathy and bone deformities, lifelong sequelae of leprosy that persist after treatment, result in significant impairment to patients and compromise their social rehabilitation.
Sandra R Boiça Silva, Antônio J Tempone, Tatiana P Silva, Maria Renata SN Costa, Geraldo MB Pereira, Flávio A Lara, Maria Cristina V Pessolani, Danuza Esquenazi   +7 more
doaj   +1 more source

Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes

Molecular Metabolism, 2019
Objective: Accumulation of visceral white adipose tissue (WAT) associates with insulin resistance, adipose tissue inflammation, and metabolic syndrome, whereas accumulation of subcutaneous WAT may be protective.
Alfred K. Ramirez, Simon Dankel, Weikang Cai, Masaji Sakaguchi, Simon Kasif, C. Ronald Kahn   +5 more
doaj   +1 more source