Production and application of peptidyl-lys metalloendopeptidase: advances, challenges, and future perspectives [PDF]
Applied Microbiology and BiotechnologyPeptidyl-lys metalloendopeptidases (PKMs) are enzymes that selectively cleave peptide bonds at the N-terminus of lysine residues present in the P1′ position, making them valuable tools in proteomics.
Uzair Ahmed +2 more
doaj +3 more sources
Membrane metalloendopeptidase (MME) is positively correlated with systemic lupus erythematosus and may inhibit the occurrence of breast cancer. [PDF]
PLoS ONE, 2023 BackgroundPatients with systemic lupus erythematosus (SLE) have a lower risk of breast cancer (BRCA) than the general population. In this study, we explored the underlying molecular mechanism that is dysregulated in both diseases.MethodsWeighted gene ...
Jiatong Ding +6 more
doaj +4 more sources
Integration of single‐cell and bulk RNA sequencing unravels metalloendopeptidase+ neutrophils as key inflammatory drivers in abdominal aortic aneurysm [PDF]
Clinical and Translational MedicineIn this ...
Lushun Yuan +4 more
doaj +3 more sources
Regulating Pathways of Bacillus pumilus Adamalysin-like Metalloendopeptidase Expression. [PDF]
Int J Mol Sci, 2023 The minor secreted proteinase of B. pumilus 3-19 MprBp classified as the unique bacillary adamalysin-like enzyme of the metzincin clan. The functional role of this metalloproteinase in the bacilli cells is not clear.
Rudakova NL +4 more
europepmc +2 more sources
Assessment of Serum Metalloendopeptidase level in Patients with Double Diabetes
مجله كليه طب الكندي, 2023 Background: Double diabetes is the term used to describe situations in which a patient exhibits characteristics that are a combination of type 1 and type 2 Diabetes Mellitus. Metalloendopeptidase or Neprilysin is membrane-bound metallopeptidase.
Hussein Jawad Hassan +2 more
doaj +2 more sources
Molecular Docking and In Vitro Studies of Ochratoxin A (OTA) Biodetoxification Testing Three Endopeptidases [PDF]
Molecules, 2023 Ochratoxin A (OTA) is considered one of the main mycotoxins responsible for health problems and considerable economic losses in the feed industry.
Pablo César Orozco-Cortés +4 more
doaj +2 more sources
A novel, robust peptidyl-lys metalloendopeptidase from Trametes coccinea recombinantly expressed in Komagataella phaffii. [PDF]
Appl Microbiol BiotechnolA novel peptidyl-lys metalloendopeptidase ( Tc -LysN) from Tramates coccinea was recombinantly expressed in Komagataella phaffii using the native pro-protein sequence.
Ahmed U +6 more
europepmc +2 more sources
Association of MME gene polymorphisms with susceptibility to Alzheimer's disease in an Iranian population [PDF]
HeliyonBackground: the MME gene encodes a membrane metalloendopeptidase, known as neprilysin (NEP). There are no reports on the potential implications of MME gene polymorphisms on the risk of Alzheimer's disease (AD) in the Iranian population. In this study, we
Fereshteh Khalili-Moghadam +4 more
doaj +2 more sources
Prophage diversity in poultry-associated Salmonella enterica from Ecuador: a case study using an in-silico terminase-based approach [PDF]
Frontiers in MicrobiologyProphages can constitute up to 30% of the accessory genome in Salmonella enterica, acting as major drivers of virulence evolution and antimicrobial resistance; however, their diversity and functional contribution in Ecuadorian poultry-associated lineages
Francisco Quelal-Madrid +4 more
doaj +2 more sources
Journal of Tissue Engineering and Regenerative Medicine, 2019 Amyloid plaque is a typical feature of Alzheimer's disease (AD) and is one of the targets for AD therapy. Membrane metalloendopeptidase (MME) and insulin‐degrading enzyme (IDE) are two types of proteases that could cleave beta‐amyloid (Aβ) peptides ...
Yong Qiao, Zhongjuan Xu, Guangli Suo
exaly +2 more sources