Results 101 to 110 of about 7,597 (252)

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

Aging Cell, Volume 25, Issue 2, February 2026.
Young multipotent muscle‐derived stem/progenitor cells (MDSPCs) secrete a unique profile of pro‐angiogenic and immunomodulatory proteins that are diminished with age. Systemic transplantation of young MDSPCs into naturally aged mice activates pathways in neuromuscular tissues, enhancing health and driving molecular, structural, and functional ...
Seth D. Thompson, Chelsea L. Rugel, Maddlyn R. Haller, Jodi L. Curtin, Sudarshan Dayanidhi, Mitra Lavasani   +5 more
wiley   +1 more source

Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes. [PDF]

PLoS ONE, 2014
Nonalcoholic steatohepatitis (NASH) is an inflammatory form of nonalcoholic fatty liver disease that progresses to liver cirrhosis. It is still unknown how only limited patients with fatty liver develop NASH.
Shoko Ishizu-Higashi, Hiroshi Seno, Eiichiro Nishi, Yoshihide Matsumoto, Kozo Ikuta, Motoyuki Tsuda, Yoshito Kimura, Yutaka Takada, Yuto Kimura, Yuki Nakanishi, Keitaro Kanda, Hideyuki Komekado, Tsutomu Chiba   +12 more
doaj   +1 more source

Function of the Signal Peptide and N- and C-terminal Propeptides in the Leucine Aminopeptidase from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e [PDF]

, 2004
The leucine aminopeptidase from Aeromonas proteolytica (also known as Vibrio proteolyticus) (AAP) is a metalloenzyme with broad substrate specificity. The open reading frame (ORF) for AAP encodes a 54 kDa enzyme, however, the extracellular enzyme has a ...
Bzymek, Krzysztof P., Campbell, Heidi, Chen, Guanjing, D\u27Souza, Ventris M., Holz, Richard C., Mitchell, Alice   +5 more
core   +1 more source

Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis [PDF]

, 2011
The plant-pathogenic fungus Mycosphaerella graminicola (asexual stage: Septoria tritici) causes septoria tritici blotch, a disease that greatly reduces the yield and quality of wheat.
Aerts, A., Antoniw, J., Bailey, A., Bluhm, B., Bowler, J., Bristow, J., Burgt, A., van der, Canto-Canché, B., Churchill, A.C.L., Conde-Ferràez, L., Cools, H.J., Coutinho, P.M., Crane, C.F., Csukai, M., Dehal, P., Dhillon, B., Donzelli, B., Foster, A.J., Geest, H.C., van de, Goodwin, S.B., Grigoriev, I.V., Grimwood, J., Ham, R.C.H.J., van, Hammond-Kosack, K.E., Hane, J.K., Henrissat, B., Kema, G.H.J., Kilian, A., Kobayashi, A.K., Koopmann, E., Kourmpetis, Y., Kuzniar, A., Lee, T.A.J., van der, Lindquist, E., Lombard, V., M'Barek, S., Ben, Maliepaard, C.A., Martins, N., Mehrabi, A., Nap, J.P.H., Oliver, R.P., Ponomarenko, A., Rudd, J.J., Salamov, A., Schmutz, J., Schouten, H.J., Shapiro, H., Stergiopoulos, I., Torriani, S.F.F., Tu, H., Vries, R.P., de, Waalwijk, C., Ware, S.B., Wiebenga, A., Wit, P.J.G.M., de, Wittenberg, A.H.J., Zwiers, L.H.   +56 more
core   +5 more sources

Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L‐ and T‐Type Ca2+ Channels in the Prevention and Treatment of Pulmonary Hypertension

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT The typical pathology of pulmonary hypertension (PH) is characterized by pulmonary vasoconstriction and irreversible pulmonary vascular remodeling. Vascular remodeling is the process of structural changes and cellular rearrangement of blood vessels due to injury and is a significant factor in conditions such as PH.
Yuefu Zhao, Jinyu Wang, Yujie Qiao, Xiangyun Gai, Jiacheng Hu, Hongmai Wang, Qingqing Xia, Qiuqin Hu, Zhanqiang Li, Cen Li, Hongtao Bi   +10 more
wiley   +1 more source

Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma

Dental Research Journal, 2016
Background: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more ...
Elham Hormozi, Vahid Nourollahi Fard, Mohammad Ali Naseri, Nima Haghighat Jahromi, Forooz Keshani   +4 more
doaj   +1 more source

A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis

Genes and Immunity, 2010
Several single-nucleotide polymorphism (SNP) genome-wide association studies (GWASs) have been completed in multiple sclerosis (MS). Follow-up studies of the variants with the most promising rankings, especially when supplemented by informed candidate ...
M. Ban, J. McCauley, R. Zuvich, A. Baker, L. Bergamaschi, M. Cox, A. Kemppinen, S. D'alfonso, F. Guerini, J. Lechner-Scott, F. Dudbridge, J. Wason, N. Robertson, P. D. De Jager, D. Hafler, L. Barcellos, A. Ivinson, D. Sexton, J. Oksenberg, S. Hauser, M. Pericak-Vance, J. Haines, Alastair Compston, S. Sawcer   +23 more
semanticscholar   +1 more source

Genomic Connectivity and Adaptation Signals of the Freshwater Sponge Ephydatia muelleri Across Its Distribution

Journal of Biogeography, Volume 53, Issue 1, January 2026.
ABSTRACT Aim Genetic connectivity and local adaptation were examined across the distribution of the freshwater sponge Ephydatia muelleri. Because it occupies an exceptional breadth of freshwater environments across a broad geographic range, this species offers key insights into biogeographic processes shaping genetic structure and adaptation in inland ...
Laura de la Cruz‐Castillejo, Robert Cassidy, Konstantina Mitsi, Carles Galià‐Camps, Ana Benítez‐López, Carlota Gracia‐Sancha, Jose Lorente‐Sorolla, Almudena Álvarez‐Fernández, Rocío Mozo, Stephen Kolomyjec, Scott Nichols, Renata Manconi, Raquel Pereira, Karen Evans, Valeria Itskovich, April L. Horton, Sally P. Leys, Sergi Taboada, Ana Riesgo   +18 more
wiley   +1 more source

Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer

Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways.
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya’an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H. Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E. I. Mustapha Bahassi, Peter J. Stambrook, Peng Huang, Jason B. Fleming, Anirban Maitra, John A. Tainer, Mien-Chie Hung, Chunru Lin, Paul J. Chiao   +30 more
doaj   +1 more source

Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases [PDF]

, 1997
Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp) and Abz-DArg-Arg-Phe ...
Boileau, G., Carvalho, K.m., França, M.s.f., Juliano, Luiz, Medeiros, M.a.s.   +4 more
core   +4 more sources