Results 121 to 130 of about 7,597 (252)

Generation of active fragments from human zymogens in the bradykinin-generating cascade by extracellular proteases from Vibrio vulnificus and V. parahaemolyticus [PDF]

, 2004
Vibrio vulnificus is an opportunistic human pathogen causing septicemia, and the infection is characterized by formation of the edematous skin lesions on limbs.
Carvalho, Hooper, Hovinga, Imamura, Ishihara, Janda, Kaminishi, Kim, Lee, Maruo, Miyoshi, Miyoshi, Miyoshi, Miyoshi, Miyoshi, Miyoshi, Molla, Morihara, Park, Semba, Shibuya, Sottrup-Jensen, Tanaka, Watanabe, Wolz, Zevaco   +25 more
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Influence of B cells in liver fibrosis associated with hepatitis B virus harboring basal core promoter mutations [PDF]

, 2012
The development of the liver disease in chronic hepatitis B with common viral variants can be determined through the interaction between the virus and the host immune response.
Mohamadkhani, A., Bastani, F., Sotoudeh, M., Sayehmiri, K., Shahnazari, P., Montazeri, G., Poustchi, H.   +6 more
core   +1 more source

Two α subunits and one β subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio [PDF]

, 2017
Meprins are members of the astacin family of metalloproteases expressed in epithelial tissues, intestinal leukocytes and certain cancer cells. In mammals, there are two homologous subunits, which form complex glycosylated disulfide-bonded homo- and ...
Becker-Pauly, Christoph, Lottaz, Daniel, Schütte, Andre, Sterchi, Erwin E., Stöcker, Walter   +4 more
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Metalloendopeptidase EC 3.4.24.15 Is Necessary for Alzheimer’s Amyloid-β Peptide Degradation*

Journal of Biological Chemistry, 1999
We have investigated the functional relationship between metalloendopeptidase EC 3.4.24.15 (MP24.15) and the amyloid precursor protein involved in Alzheimer’s disease (AD) and discovered that the enzyme promotes Aβ degradation.
R. Yamin, Eric G. Malgeri, J. Sloane, W. Mcgraw, C. Abraham   +4 more
semanticscholar   +1 more source

Variants in MME are associated with autosomal‐recessive distal hereditary motor neuropathy

Annals of Clinical and Translational Neurology, 2019
Objective To identify a new genetic cause in patients segregating distal hereditary motor neuropathy (dHMN) with an autosomal recessive pattern. Methods Whole‐exome sequencing was conducted in two siblings and was combined with segregation analysis ...
Daojun Hong, Pu Fang, Sheng Yao, Juanjuan Chen, Xiaolei Zhang, Shuyun Chen, Jingfen Zhang, Dandan Tan, Li Wang, Xinsheng Han, Ling Xin, Yan Wang, Meige Liu, Lu Cong, Shanshan Zhong, Hui Ouyang, Xuguang Gao, Jun Zhang   +17 more
doaj   +1 more source

A Disintegrin and Metalloprotease‐22 Attenuates Hypertrophic Remodeling in Mice Through Inhibition of the Protein Kinase B Signaling Pathway

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Severe cardiac hypertrophy can lead to cardiac remodeling and even heart failure in the end, which is a leading cause of cardiovascular disease–related mortality worldwide.
Lingyun Ren, Chuangyan Wu, Kai Yang, Shanshan Chen, Ping Ye, Jie Wu, Anchen Zhang, Xiaofan Huang, Ke Wang, Peng Deng, Xiangchao Ding, Manhua Chen, Jiahong Xia   +12 more
doaj   +1 more source

CD10 expression in urothelial carcinoma of the bladder

Diagnostic Pathology, 2009
Background CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase and it is expressed in a variety of normal and neoplastic lymphoid and nonlymphoid tissues.
Bozkurt Erol R, Bektas Sibel, Behzatoglu Kemal, Bahadir Burak, Ozdamar Sukru O   +4 more
doaj   +1 more source

Simulated Microgravity Regulates Gene Transcript Profiles of 2T3 Preosteoblasts: Comparison of the Random Positioning Machine and the Rotating Wall Vessel Bioreactor [PDF]

Microgravity of spaceflight induces bone loss due in part to decreased bone formation by osteoblasts. We have previously examined the microgravity-induced changes in gene expression profiles in 2T3 preosteoblasts using the Random Positioning Machine (RPM)
Hanjoong, Jo, Liu, Wenbin, Patel, Mamta J., Risin, Diana, Risin, Semyon A., Sykes, Michelle C., Ward, Nancy E.   +6 more
core   +1 more source

eP043: Membrane Metalloendopeptidase (MME) positively regulates Phosphoinositide 3-Kinase (PI3K) signaling in triple negative breast cancer

Genetics in Medicine, 2022
M. Mina, R. Conway, Reed Haga, C. Obregon, Purva Patel, M. Comstock, E. Whiting, Jazmine Stubblefield, E. Seyoum, Tarek Alhamami, M. Zaki   +10 more
semanticscholar   +1 more source

Protein Regge Trajectories, Phase Coexistence and Loop Aetiology in Alzheimers Disease [PDF]

, 2011
Alzheimer's disease has a devastating impact on its victims by causing severe neurodegeneration in the brain that leads to a certain death. Only in a small number of cases can the origin be traced to a variety of genetic mutations, for the greater ...
Andrey Krokhotin, Antti Niemi
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