Results 11 to 20 of about 3,502 (121)

Integration of single‐cell and bulk RNA sequencing unravels metalloendopeptidase+ neutrophils as key inflammatory drivers in abdominal aortic aneurysm

Clinical and Translational Medicine, Volume 14, Issue 12, December 2024.
Lushun Yuan, Chuan Liang, Shuzhen Cheng, Jian‐Liang Zhou, Song Chen   +4 more
openalex   +2 more sources

Progress of ADAM17 in Fibrosis-Related Diseases. [PDF]

Mediators Inflamm
Fibrosis leads to structural damage and functional decline and is characterized by an accumulation of fibrous connective tissue and a reduction in parenchymal cells. Because of its extremely poor prognosis, organ fibrosis poses a significant economic burden.
Yan S, Zhao Y, Yang Y, Liu B, Xu W, Ma Z, Yang Q.   +6 more
europepmc   +2 more sources

The impact of 60 days of ‐6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Reductions in skeletal muscle mitochondrial respiration following 60 days of bed rest explained by a decrease in mitochondrial content, but resulting in an increase in OPA1 and Drp1 mediated mitochondrial fission. Abstract It is unclear how skeletal muscle metabolism and mitochondrial function adapt to long duration bed rest and ...
John Noone, Anthony Damiot, Helena Kenny, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, François Crampes, Isabelle de Glisezinski, Keith D. Rochfort, Claire Laurens, Marie‐Pierre Bareille, Chantal Simon, Audrey Bergouignan, Stéphane Blanc, Donal J. O'Gorman   +14 more
wiley   +1 more source

gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. [PDF]

PLoS ONE, 2014
In order to sustain lifelong production of gametes, many animals have evolved a stem cell-based gametogenic program. In the Drosophila ovary, germline stem cells (GSCs) arise from a pool of primordial germ cells (PGCs) that remain undifferentiated even ...
Shinya Matsuoka, Swati Gupta, Emiko Suzuki, Yasushi Hiromi, Miho Asaoka   +4 more
doaj   +1 more source

Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Toxins, 2016
The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom.
Viviane A. Bastos, Francisco Gomes-Neto, Jonas Perales, Ana Gisele C. Neves-Ferreira, Richard H. Valente   +4 more
doaj   +1 more source

A novel, robust peptidyl-lys metalloendopeptidase from Trametes coccinea recombinantly expressed in Komagataella phaffii. [PDF]

Appl Microbiol Biotechnol
Ahmed U, Stadelmann T, Heid D, Würtz B, Pfannstiel J, Ochsenreither K, Eisele T.   +6 more
europepmc   +3 more sources

Purification, characterization, and structural elucidation of serralysin-like alkaline metalloprotease from a novel source

Journal of Genetic Engineering and Biotechnology, 2019
Background Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications.
Swathi Nageswara, Girijasankar Guntuku, Bhagya Lakshmi Yakkali   +2 more
doaj   +1 more source

Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in Campylobacter and Salmonella Patients

Diagnostics, 2018
Campylobacters are major enteropathogens worldwide with a substantial financial burden. Matrix metalloproteinases (MMPs) are proteolytic metalloendopeptidases with ability to modify immune response and shown to be upregulated in patients with several ...
Anna Nilsson, Taina Tervahartiala, David Lennebratt, Anders Lannergård, Timo Sorsa, Hilpi Rautelin   +5 more
doaj   +1 more source

Not so Dangerous After All? Venom Composition and Potency of the Pholcid (Daddy Long-Leg) Spider Physocyclus mexicanus

Frontiers in Ecology and Evolution, 2019
Pholcid spiders (Araneae: Pholcidae), officially “cellar spiders” but popularly known as “daddy long-legs,” are renown for the potential of deadly toxic venom, even though venom composition and potency has never formally been studied.
Pamela A. Zobel-Thropp, Jennifer Mullins, Charles Kristensen, Brent A. Kronmiller, Cynthia L. David, Linda A. Breci, Greta J. Binford   +6 more
doaj   +1 more source

Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities

Journal of Oral Biology and Craniofacial Research, 2023
Salivary gland (SG) extracellular matrix (ECM) has a major influence on tissue development, homeostasis, and tissue regeneration after injury. During aging, disease, and physical insult, normal remodeling of the SG microenvironment (i.e.
Milos Marinkovic, Olivia N. Tran, Hanzhou Wang, Parveez Abdul-Azees, David D. Dean, Xiao-Dong Chen, Chih-Ko Yeh   +6 more
doaj