Results 21 to 30 of about 3,502 (121)

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

New Plant Protection, EarlyView.
Applying population genomics, this study revealed that Pst exhibits slower linkage disequilibrium decay compared to rust fungi with known sexual reproduction, identified extensive hard and soft sweeps linked to Pst adaptation, and demonstrated that crop domestication and breeding programs have significantly influenced pathogen population sizes ...
Yun Xing, Chongjing Xia, Liang Huang, Na Zhao, Hongfu Li, Xingzong Zhang, Age Qiu, Wanqiang Tang, Meinan Wang, Xianming Chen, Bo Liu, Hao Zhang, Li Gao, Wanquan Chen, Taiguo Liu   +14 more
wiley   +1 more source

Nonsense Mutations in Rare and Ultra‐Rare Human Disorders: An Overview

IUBMB Life, Volume 77, Issue 6, June 2025.
ABSTRACT Over 7000 rare diseases have been described, collectively affecting 350 million people worldwide. Most of these conditions result from nonsense mutations, representing approximately 10% of all genetic mutations associated with human inherited diseases.
Emanuele Vitale, Davide Ricci, Federica Corrao, Ignazio Fiduccia, Ilenia Cruciata, Pietro Salvatore Carollo, Alessio Branchini, Laura Lentini, Ivana Pibiri   +8 more
wiley   +1 more source

Exploring the Effect and Mechanism of Liraglutide in Treating Depression Based on Network Pharmacology and Experimental Analysis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Depression is a disorder caused by various reasons, with low mood as the main symptom, and it has a serious impact on mental health. Liraglutide (Lir) has been confirmed to alleviate neuroinflammation and depression‐like behaviours induced by chronic stress, but its underlying mechanisms remain unclear.
Jiangjin Sun, Xiying Fu, Yaqi Liu, Tian Wang, Xing Zhao, Ranji Cui, Wei Yang   +6 more
wiley   +1 more source

Transcriptional Profiling of SSEA‐1+ Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Sampling, isolation, cell sorting and microarray analysis of SSEA‐1+ endometrial epithelial progenitor cells. Gene expression data was analysed using computational pathway analysis methods and internally validated using real‐time quantitative PCR and externally validated using dual‐label immunofluorescence and endometrial epithelial organoid models ...
Hannan Al‐Lamee, Jamie Soul, Daniel Green, Josephine Drury, Christopher J. Hill, Olga Vasieva, Anthony Valentijn, Alison Maclean, Andrew Drakeley, Nicola Tempest, Dharani K. Hapangama   +10 more
wiley   +1 more source

Alzheimer's Disease and Frontotemporal Dementia: A Review of Pathophysiology and Therapeutic Approaches

Journal of Neuroscience Research, Volume 103, Issue 5, May 2025.
ABSTRACT Alzheimer's disease (AD) is a devastating form of dementia, with the number of affected individuals rising sharply. The main hallmarks of the disease include amyloid‐beta plaque deposits and neurofibrillary tangles consisting of hyperphosphorylated tau protein, besides other pathological features that contribute to the disease's complexity ...
Sally Kelliny, Xin‐Fu Zhou, Larisa Bobrovskaya   +2 more
wiley   +1 more source

Identification and characterization of a novel QTL for barley yellow mosaic disease resistance from bulbous barley

The Plant Genome, Volume 18, Issue 1, March 2025.
Abstract Winter barley (Hordeum vulgare) production areas in the middle and lower reaches of the Yangtze River are severely threatened by barley yellow mosaic disease, which is caused by Barley yellow mosaic virus and Barley mild mosaic virus. Improving barley disease resistance in breeding programs requires knowledge of genetic loci in germplasm ...
Yi Hong, Hui Zhou, Mengna Zhang, Yuhang Zhang, Juan Zhu, Chao Lv, Baojian Guo, Feifei Wang, Qingliang Li, Jie Sun, Rugen Xu   +10 more
wiley   +1 more source

Enhancement of adipose stem cell quality via Cu‐MON: Transcriptome and bioinformatics analysis of normal and diabetic stem cells

FASEB BioAdvances, Volume 7, Issue 3, March 2025.
RNA sequencing, KEGG and GO enrichment analysis showed that Cu‐MON improved ASC cell quality by regulating immune response and promoting paracrine secretion through IL‐17 signaling pathway. Cu‐MON also improved stem cell antiviral ability through Type I interferon signaling pathway.
Ruixin Pang, Kaijing Liu, Biou Liu, Jing Yang   +3 more
wiley   +1 more source

Decoding small peptides: Regulators of plant growth and stress resilience

Journal of Integrative Plant Biology, Volume 67, Issue 3, Page 596-631, March 2025.
This review explores how small peptides act as key regulators of plant growth, development, and stress responses. It highlights recent advances in small peptide identification and their roles in enhancing plant resilience to environmental challenges, offering new perspectives for improving crop productivity.
Fei Xiao, Huapeng Zhou, Honghui Lin
wiley   +1 more source

Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Proteomic evaluation of plasma samples could accelerate the identification of novel Alzheimer's disease (AD) biomarkers. We evaluated the novel NUcleic acid Linked Immuno‐Sandwich Assay (NULISA) proteomic method in an ethnically diverse cohort.
Xuemei Zeng, Anuradha Sehrawat, Tara K. Lafferty, Yijun Chen, Mahika Rawat, M. Ilyas Kamboh, Victor L. Villemagne, Oscar L. Lopez, Ann D. Cohen, Thomas K. Karikari   +9 more
wiley   +1 more source

Whole Genome Sequencing Reveals Clade‐Specific Genetic Variation in Blacklegged Ticks

Ecology and Evolution, Volume 15, Issue 2, February 2025.
In this study, we performed whole genome nanopore sequencing of individual blacklegged ticks across their geographical range to evaluate genetic divergence among populations. Our integrated analyses identified genetic variants associated with numerous biological processes and molecular functions that segregated across populations.
Jacob Cassens, Adela S. Oliva Chávez, Danielle M. Tufts, Jianmin Zhong, Christopher Faulk, Jonathan D. Oliver   +5 more
wiley   +1 more source