EFSA Journal, Volume 23, Issue 2, February 2025.Abstract The food enzyme bacillolysin (EC 3.4.24.28) is produced with the genetically modified Bacillus amyloliquefaciens strain NPR by DSM Food Specialties B.V. The production strain meets the requirements for the qualified presumption of safety (QPS) status. The genetic modifications do not give rise to safety concerns. The food enzyme was considered
EFSA Panel on Food Enzymes (FEZ) +19 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 1, January 2025.Novel Ubiquitin‐Specific Protease‐30 (USP30) inhibitors target a key deubiquitinating enzyme, USP30, promoting the ubiquitination and subsequent clearance of dysfunctional mitochondria through the mitophagy pathway. This process offers therapeutic benefits in neurodegenerative diseases by enhancing neuronal cell health.
Ankit Siwach +3 more
wiley +1 more source
Current Understanding of Feather Keratin and Keratinase and Their Applications in Biotechnology
Biochemistry Research International, Volume 2025, Issue 1, 2025.The food industry generates substantial keratin waste, particularly chicken feathers, which are rich in amino acids and essential nutrients. However, the insolubility of keratin presents a significant challenge to its conversion. Keratinase, an enzyme produced by certain fungi and bacteria, offers a promising solution by degrading feather keratin into ...
Thanakorn Moktip +6 more
wiley +1 more source
Charcot‐Marie‐Tooth disease in children
Annals of the Child Neurology Society, Volume 2, Issue 4, Page 256-268, December 2024.Abstract Charcot‐Marie‐Tooth (CMT) disease represents a diverse group of inherited neuropathies with a broad spectrum of symptoms. It is the most prevalent inherited neuropathy, with an estimated prevalence ranging from 9.7 to 82 cases per 100,000 individuals.
Ezgi Saylam +4 more
wiley +1 more source
Immunity, Inflammation and Disease, Volume 12, Issue 12, December 2024.We established a novel gene signature associated with butyrate metabolism, serving as a sensitive predictive biomarker for the prognosis of LUAD patients. We underscored the necessity for further comprehensive investigations to unveil the regulatory mechanisms governing butyrate metabolism in LUAD. ABSTRACT Background Experimental results have verified
Jing Zhao +6 more
wiley +1 more source
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells
JOR SPINE, Volume 7, Issue 4, December 2024.Extracellular vesicles (EVs) derived from human intervertebral disc cells present markers CD9, CD81, CD82, ALIX, FLOT1/2, TSG101, and ANXA5 with differential expression levels linked to the degenerative grade of the tissue. The proteomic cargo is majorly shared but the expression levels vary with degeneration grade.
Li Li +8 more
wiley +1 more source
Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells [PDF]
, 2020 Chieh-Yang Cheng +6 more
openalex +1 more source
Characterization of the bacterial metalloendopeptidase pitrilysin by use of a continuous fluorescence assay [PDF]
, 1993 Angela Xuereb‐Anastasi +2 more
openalex +1 more source
N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface [PDF]
, 2000 Véronique HOSPITAL +6 more
openalex +1 more source
The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF) [PDF]
, 2002 Véronique HOSPITAL +5 more
openalex +1 more source