Results 61 to 70 of about 5,484 (240)

Safety evaluation of an extension of use of the food enzyme bacillolysin from the non‐genetically modified Bacillus amyloliquefaciens strain AGS 430

EFSA Journal, Volume 23, Issue 8, August 2025.
Abstract The food enzyme bacillolysin (EC 3.4.24.28) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AGS 430 by Kerry Ingredients & Flavours Ltd. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in 11 food ...
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Jeroen Pasch, Yi Liu   +14 more
wiley   +1 more source

Formyl Peptide Receptor 1 Modulates Endothelial Cell Functions by NADPH Oxidase-Dependent VEGFR2 Transactivation [PDF]

, 2018
In the vasculature, NADPH oxidase is the main contributor of reactive oxygen species (ROS) which play a key role in endothelial signalling and functions. We demonstrate that ECV304 cells express p47phox, p67phox, and p22phox subunits of NADPH oxidase, as
Ammendola, Rosario, Castaldo, Martina, Cattaneo, Fabio, Esposito, Gabriella, Faraonio, Raffaella, Parisi, Melania   +5 more
core   +3 more sources

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, Volume 98, Issue 1, Page 67-79, July 2025.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

Enzyme kinetics of protease from Hypsizygus ulmarius [PDF]

, 2014
Enzyme kinetics of protease activity from ext. of edible mushroom, Hypsizygus ulmarius were carried out. The optimum pH and temp. for protease activity were found to be at 10 and 40°C resp. The pH and temp.
Premkumari, B., Shivashankar, M.
core   +1 more source

Tectorigenin Ameliorates Glucocorticoid‐Induced Osteoporosis by Inhibiting the NF‐κB Signal Pathway and Modulating Treg‐Th17 Cell Balance

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT Glucocorticoid‐induced osteoporosis is a common clinical orthopaedic disease, primarily due to excessive use of hormones. Tectorigenin has shown a certain efficacy in treating osteoporosis, but its underlying mechanisms are not yet fully understood.
Peng Peng, Puiian Wong, Zheng Lv, Jiaqing Tian, Wei He, Qiushi Wei, Hui Mo, Mincong He   +7 more
wiley   +1 more source

The impact of 60 days of −6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics

The Journal of Physiology, Volume 603, Issue 13, Page 3777-3794, 1 July 2025.
Abstract figure legend Reductions in skeletal muscle mitochondrial respiration following 60 days of bed rest explained by a decrease in mitochondrial content, but resulting in an increase in OPA1 and Drp1 mediated mitochondrial fission. Abstract It is unclear how skeletal muscle metabolism and mitochondrial function adapt to long duration bed rest and ...
John Noone, Anthony Damiot, Helena Kenny, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, François Crampes, Isabelle de Glisezinski, Keith D. Rochfort, Claire Laurens, Marie‐Pierre Bareille, Chantal Simon, Audrey Bergouignan, Stéphane Blanc, Donal J. O'Gorman   +14 more
wiley   +1 more source

Nonsense Mutations in Rare and Ultra‐Rare Human Disorders: An Overview

IUBMB Life, Volume 77, Issue 6, June 2025.
ABSTRACT Over 7000 rare diseases have been described, collectively affecting 350 million people worldwide. Most of these conditions result from nonsense mutations, representing approximately 10% of all genetic mutations associated with human inherited diseases.
Emanuele Vitale, Davide Ricci, Federica Corrao, Ignazio Fiduccia, Ilenia Cruciata, Pietro Salvatore Carollo, Alessio Branchini, Laura Lentini, Ivana Pibiri   +8 more
wiley   +1 more source

Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates [PDF]

, 2017
Zinc metallopeptidases of bacterial pathogens are widely distributed virulence factors and represent promising pharmacological targets. In this work, we have characterized Zmp1, a zinc metallopeptidase identified as a virulence factor of Mycobacterium ...
Amstutz, Beat, Baici, Antonio, Coletta, Massimo, Ferraris, Davide M., Gioia, Magda, Hähnlein, Janine, Marini, Stefano, Petrera, Agnese, Rizzi, Menico, Sander, Peter, Sbardella, Diego, Selchow, Petra   +11 more
core  

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

New Plant Protection, Volume 2, Issue 2, June 2025.
Applying population genomics, this study revealed that Pst exhibits slower linkage disequilibrium decay compared to rust fungi with known sexual reproduction, identified extensive hard and soft sweeps linked to Pst adaptation, and demonstrated that crop domestication and breeding programs have significantly influenced pathogen population sizes ...
Yun Xing, Chongjing Xia, Liang Huang, Na Zhao, Hongfu Li, Xingzong Zhang, Age Qiu, Wanqiang Tang, Meinan Wang, Xianming Chen, Bo Liu, Hao Zhang, Li Gao, Wanquan Chen, Taiguo Liu   +14 more
wiley   +1 more source

Exploring the Effect and Mechanism of Liraglutide in Treating Depression Based on Network Pharmacology and Experimental Analysis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Depression is a disorder caused by various reasons, with low mood as the main symptom, and it has a serious impact on mental health. Liraglutide (Lir) has been confirmed to alleviate neuroinflammation and depression‐like behaviours induced by chronic stress, but its underlying mechanisms remain unclear.
Jiangjin Sun, Xiying Fu, Yaqi Liu, Tian Wang, Xing Zhao, Ranji Cui, Wei Yang   +6 more
wiley   +1 more source