Results 111 to 120 of about 4,715 (225)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Global Proteomic Analysis of Sperm and Seminal Plasma From Tropically‐Adapted Rams With Contrasting Parameters of Frozen‐Thawed Semen

Molecular Reproduction and Development, Volume 93, Issue 10, October 2026.
ABSTRACT The aim of this study was to characterize the proteome of sperm and seminal plasma (SP) from rams with high semen freezability (HF) and low semen freezability (LF). Eleven ejaculates were collected from 12 rams, at 3‐day intervals, and cryopreserved (132 semen samples).
Wallisson Bruno de Morais Pacheco, Iran Aguila Maciel, Suane Santos Alves dos Santos, Alan Martins de Araújo, Francisca Nágila Matos Almeida, Denise Damasceno Guerreiro, Sheheryar Sheheryar, Lais Lacerda Brasil de Oliveira, Felipe Domingos de Sousa, Mohibullah Shah, Maria Elisabete Amaral Moraes, Carlos Roberto Koscky Paier, Ana Cristina de Oliveira Monteiro, Carminda Sandra Brito Salmito‐Vanderley, Arlindo A. Moura   +14 more
wiley   +1 more source

Peripheral Blood Expression of MMPs and DNA Methylation-Related Genes in Women with Recurrent Spontaneous Abortion: A Case-Control Study [version 2; peer review: 2 approved]

F1000Research
Background Recurrent spontaneous abortion (RSA) is one of the most common reproductive complications among women of childbearing age. Several factors—including genetic, anatomical, endocrine, infectious, environmental, and immunological causes—have been ...
Fateme Zare, Maryam Imani, Farzaneh Fesahat, Fateme Rahmani, Hossein Hadinedoushan   +4 more
doaj   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, Volume 14, Issue 7, Page 2150-2159, October 2026.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Change in expression of extracellular matrix factor genes in 24

, 2014
Change in expression of extracellular matrix (ECM) factor genes 24 h following spinal cord injury at P28, subdivided into ECM, metallopeptidases, inhibitors, proteoglycans, laminins and integrins.
Jessie Truettner (575724), Mark D. Habgood (141619), W. Dalton Dietrich (195828), Helen Lindsay (47301), Katarzyna M. Dziegielewska (141625), David L. Steer (195811), C. Joakim Ek (141616), Matthew J. Wakefield (114499), Natassya M. Noor (195806), Robert D. Miller (134014), Benjamin J. Wheaton (195816), A. Ian Smith (146340), Norman R. Saunders (141628), Shane A. Liddelow (177268)   +13 more
core   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Molecular basis of urostyle development in frogs: genes and gene regulation underlying an evolutionary novelty

Open Biology
Evolutionary novelties entail the origin of morphologies that enable new functions. These features can arise through changes to gene function and regulation.
Gayani Senevirathne, Neil H. Shubin
doaj   +1 more source